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2000
Volume 15, Issue 4
  • ISSN: 2468-1873
  • E-ISSN: 2468-1881

Abstract

Hydrophilic drugs are proficient therapeutic drug candidates; however, their effective delivery poses a formidable challenge. Therefore, the development of an efficient drug delivery system demands a multifaceted approach. In recent decades, nanolipid carriers have emerged as promising drug delivery systems, offering enhanced stability, improved bioavailability, and controlled release profiles. Although nanolipid carriers have been widely investigated as carriers for hydrophobic drugs and have demonstrated remarkable success in encapsulating hydrophobic drugs, encapsulating a hydrophilic drug moiety still remains a challenge.

The current study provides a comprehensive review of innovative methods developed for the successful encapsulation of hydrophilic drugs into nanolipid carriers. The first section of the study explores the physicochemical properties of hydrophilic drugs and the inherent challenges associated with their encapsulation in lipid-based carriers. The subsequent sections delve into the various strategies employed to overcome these challenges. Emphasis is placed on novel formulation techniques investigated for the encapsulation of hydrophilic drugs into nano lipid carriers. The present review not only delineates the various traditional methods for high entrapment of hydrophilic drugs but also underscores modifications to the hydrophilic drug candidates, facilitating their efficient encapsulation into nanolipid carrier drug carriers.

This study explores the current state of knowledge regarding methods for encapsulating hydrophilic drugs into nanolipid carriers. By addressing the challenges associated with hydrophilic drug encapsulation and presenting innovative strategies, this review aims to provide valuable insights to researchers and pharmaceutical scientists working in the field of nanomedicine and drug delivery.

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Methods for the Encapsulation of Hydrophilic Drugs in Lipid-Based Nanocarriers, Solid Lipid Nanoparticles, and Nanostructured Lipid Carriers: A Short Review and Perspective
Curr Nanomed 15, 448 (2025); https://doi.org/10.2174/0124681873316337240515080103
/content/journals/cnanom/10.2174/0124681873316337240515080103
/content/journals/cnanom/10.2174/0124681873316337240515080103
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  • Article Type:     Review Article
Keyword(s): double emulsification solvent evaporation method; encapsulation; hydrophilic drug; Nanolipid carrier; NLC; SLN

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