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2000
Volume 15, Issue 4
  • ISSN: 2468-1873
  • E-ISSN: 2468-1881

Abstract

Background

To enhance the solubility of simvastatin by improving the surface area of the drug particle by preparing nanosponges that are enclosed in a tablet and capsule oral solid dosage forms, which in turn helps maintain the drug's stability.

Objective

The present investigation aimed to develop a simvastatin nanosponge containing Eudragit as a polymer with different ratios of drug-to-polymer concentration to increase its solubility and further improve the oral bioavailability by using nanosponges’ formulation technique.

Methods

The emulsion solvent diffusion method was used to prepare simvastatin nanosponges by using Eudragit S 100, Eudragit L 100, and a combination of both in different drug-to-polymer ratios, ., 1:0.5, 1:1, 1:1.5, and 1:2. To characterize the conductivity, molecular changes, and size of the prepared nanosponges, a variety of evaluation parameters, including the compressibility index, Hausner's ratio, angle of repose, microscopy, production yield, entrapment efficiency, drug content, drug release studies, DSC, XRD, FTIR, and SEM were evaluated. Optimized formulation was used to prepare colon-targeted tablets and capsules by taking nanosponges equivalent to 20 mg of simvastatin.

Results

The percentage yield, drug content, and entrapment efficiency of the final formulation were observed at 81 ± 0.26%, 92.4%, and 97 ± 0.56%, respectively. The drug release of the optimized formulations was 91.42% at 12 hrs. The drug release followed the Peppas model with a super case II transport mechanism.

Conclusion

The use of the nanosponge delivery system increased the solubility of simvastatin seven times, which in turn increased the drug's bioavailability.

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2025-10-11

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Formulation and Characterization of Simvastatin-Loaded Nanosponges: An Innovative Technique for Colon-Targeted Drug Delivery
Curr Nanomed 15, 459 (2025); https://doi.org/10.2174/0124681873297155240220062817
/content/journals/cnanom/10.2174/0124681873297155240220062817
/content/journals/cnanom/10.2174/0124681873297155240220062817
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  • Article Type:     Research Article
Keyword(s): bioavailability; colon targeted drug delivery; eudragit; nanosponges; Simvastatin; solubility

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