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2000
Volume 15, Issue 5
  • ISSN: 2468-1873
  • E-ISSN: 2468-1881

Abstract

Introduction

Poor drug solubility and permeability, particularly in BCS Class IV drugs, hamper their pharmacokinetics and targeted action. This study aims to address this by utilizing starch nanoparticles as a novel carrier for enhanced delivery and improved bioavailability. Formulation and evaluation of the QLSS nanoparticles as a drug delivery system.

Objective

Formulation of the QLSS nanoparticles and their % drug entrapment, drug loading, average particle size, surface morphological examination, drug release study, and cytotoxicity activity using an MTT assay against the A549 cancer cell line.

Methods

QLSS nanoparticles were prepared by the nanoprecipitation technique with some modifications, &assessment, including surface morphological analysis, drug loading, drug entrapment percentage, average particle size, drug release study, and cytotoxicity activity.

Results

The average particle size and surface morphology of prepared optimized QLSS nanoparticles (QLSS 3) were found to be approximately 43.24-113.51 nm and spherical in shape with a 292.1nm Z-average size. The percentage yield was found to be 80 ± 2.0% of QLSS-3. Loading capacity and the percentages of drug encapsulation efficiency were found to be 42.5 ± 1.2% and 68 ± 2.2%, respectively. The results of the drug's release were found to be 96.12 ± 1.8% within 12 hours. 10µg/ml of QLSS 3 inhibited 66.31 ± 1.4% of A549 cancer cells.

Conclusion

In this research study, sago starch was used for the first time as a drug carrier for quercetin. The results of the studies confirmed the improvement in pharmacokinetic parameters of the BCS-IV class drug.

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2024-07-23
2025-10-11

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Formulation and Evaluation of Quercetin Loaded Sago Starch Nanoparticles
Curr Nanomed 15, 637 (2025); https://doi.org/10.2174/0124681873299675240628125625
/content/journals/cnanom/10.2174/0124681873299675240628125625
/content/journals/cnanom/10.2174/0124681873299675240628125625
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  • Article Type:     Research Article
Keyword(s): amylopectin nanoparticles; amylose nanoparticles; QLSS; sago stach nanoparticles; sago starch; Starch nanoparticle

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