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2000
Volume 15, Issue 4
  • ISSN: 2468-1873
  • E-ISSN: 2468-1881

Abstract

Objective

The majority of new chemical substances generated by the drug development process are poorly water-soluble or lipophilic. Formulation of a poorly water-soluble substance is a difficult task for the pharmaceutical industry. It is widely acknowledged that using nanosuspension in drug administration enhances the drug’s solubility, dissolution, and ultimately bioavailability. This study aimed to examine the particle sizes of nanosuspensions made by nanoprecipitation techniques and improve their effectiveness.

Methods

Aprepitant’s nanosuspension has been produced by nanoprecipitation techniques. The particle size, polydispersity index, along zeta potential of the produced nanosuspensions were measured. The optimized nanosuspension has been investigated further for solubility, dissolution, surface morphology, FT-IR, DSC as well as stability studies.

Results

The combination of tween 80 and poloxamer 188 as stabilizer resulted in the preparation of an optimized nanosuspension (F9) with a particle size of 738 nm, polydispersity index 0.236, zeta potential -15.1 mV and an improved solubility and dissolution profile compared to pure drugs. Positive performance improvement was observed in the solubility and dissolution studies. The crystallinity changed upon nanosizing, as demonstrated by the SEM, FT-IR and DSC analysis.

Conclusion

The nanoprecipitation method was effective in producing a stable Aprepitant nanosuspension with improved solubility and dissolution rate.

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2024-03-21
2025-10-11

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Formulation and Evaluation of Aprepitant Nanosuspension by Nano Precipitation Techniques
Curr Nanomed 15, 472 (2025); https://doi.org/10.2174/0124681873299074240307093319
/content/journals/cnanom/10.2174/0124681873299074240307093319
/content/journals/cnanom/10.2174/0124681873299074240307093319
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  • Article Type:     Research Article
Keyword(s): Aprepitant; bioavailability; nanoprecipitation techniques; nanosuspension; polydispersity; solubility profile

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