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2000
Volume 21, Issue 6
  • ISSN: 1573-4137
  • E-ISSN: 1875-6786

Abstract

Introduction

Iron oxide nanoparticles have gained significant attention in pharmaceutical applications because of their unique properties. The hydrothermal method is employed for the synthesis of iron nanoparticles (IONPs), which offers advantages such as uniform composition and size distribution.

Methods

However, the size and properties of IONPs can be influenced by various factors. In this study, we utilized quality by design (QBD) response surface methodology to investigate the impact of temperature, time, and pH on the size of hydrothermally prepared IONPs. The optimized synthesis conditions were determined, and the resulting nanoparticles were characterized using techniques such as dynamic light scattering (DLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).

Results

The findings contribute to a better understanding of the controlled synthesis of IONPs and their potential applications in nanomedicine. The XRD characterization revealed that the product was FeO. The FTIR results indicate that FeO nanoparticles were coated with PEG-400. The SEM and HRTEM images of the FeO nanoparticles showed that they were spherical and had a well-distributed size with an optimized hydrodynamic size of 65 nm.

Conclusion

The magnetic properties of the FeO nanoparticles indicated that they exhibited ferromagnetic properties. These prepared nanoparticles are suitable for biomedical purposes, like serving as contrast agents for magnetic resonance imaging in different cancers and delivering drugs.

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Controlled Synthesis of Iron Oxide Nanoparticles via QBD for Biomedical Applications
Curr. Nanosci. 21, 1056 (2025); https://doi.org/10.2174/0115734137336579241008054823
/content/journals/cnano/10.2174/0115734137336579241008054823
/content/journals/cnano/10.2174/0115734137336579241008054823
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  • Article Type:     Research Article
Keyword(s): drug delivery; hydrothermal method; hyperthermia treatments; Iron oxide nanoparticles; nanomedicine; response surface methodology

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