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2000
Volume 24, Issue 2
  • ISSN: 1570-159X
  • E-ISSN: 1875-6190

Abstract

Autism Spectrum Disorders (ASD) are complex neurodevelopmental conditions characterized by impaired social communication, repetitive behavior patterns, and atypical sensory perception. The Autism and Developmental Disabilities Monitoring Network reports that approximately 1 in 36 children are diagnosed with ASD, highlighting the increasing prevalence and the pressing need for innovative treatment approaches. Medications commonly used in ASD primarily aim to manage associated symptoms, as there are currently no FDA-approved medications specifically for treating ASD core symptoms. Stem cells have demonstrated significant potential in cell-based therapies for ASD and have been utilized in models to investigate the pathogenesis of the condition. This review focuses on the recent advancements in stem cell-based transplantation in animal models of ASD, aiming to explore the improvement of ASD symptoms and the underlying mechanisms involved. It also discussed the application of stem cell-based transplantation in pediatric and adolescent populations with ASD to evaluate treatment efficacy and potential preventive strategies. Furthermore, recent efforts are addressed in developing stem cell-based models for both syndromic and non-syndromic forms of ASD, emphasizing studies that utilize cerebral organoids for modeling ASD, which facilitate the exploration of disease mechanisms within a tissue-like environment.

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2026-02-26

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References

  1. KimH. KeiferC.M. Rodriguez-SeijasC. EatonN.R. LernerM.D. GadowK.D. Structural hierarchy of autism spectrum disorder symptoms: An integrative framework.J. Child Psychol. Psychiatry2018591303810.1111/jcpp.1269828195316
     [Google Scholar]
  2. KimH. KeiferC. Rodriguez-SeijasC. EatonN. LernerM. GadowK. Quantifying the optimal structure of the autism phenotype: A comprehensive comparison of dimensional, categorical, and hybrid models.J. Am. Acad. Child Adolesc. Psychiatry2019589876886.e210.1016/j.jaac.2018.09.43130768420
     [Google Scholar]
  3. SheldrickR.C. MayeM.P. CarterA.S. Age at first identification of autism spectrum disorder: An analysis of two US surveys.J. Am. Acad. Child Adolesc. Psychiatry201756431332010.1016/j.jaac.2017.01.01228335875
     [Google Scholar]
  4. MaennerM.J. WarrenZ. WilliamsA.R. AmoakoheneE. BakianA.V. BilderD.A. DurkinM.S. FitzgeraldR.T. FurnierS.M. HughesM.M. Ladd-AcostaC.M. McArthurD. PasE.T. SalinasA. VehornA. WilliamsS. EslerA. GrzybowskiA. Hall-LandeJ. NguyenR.H.N. PierceK. ZahorodnyW. HudsonA. HallasL. MancillaK.C. PatrickM. ShenoudaJ. SidwellK. DiRienzoM. GutierrezJ. SpiveyM.H. LopezM. PettygroveS. SchwenkY.D. WashingtonA. ShawK.A. Prevalence and characteristics of autism spectrum disorder among children aged 8 years — autism and developmental disabilities monitoring network, 11 Sites, United States, 2020.MMWR Surveill. Summ.202372211410.15585/mmwr.ss7202a136952288
     [Google Scholar]
  5. HowlinP. MagiatiI. CharmanT. Systematic review of early intensive behavioral interventions for children with autism.Am. J. Intellect. Dev. Disabil.20091141234110.1352/2009.114:23;nd4119143460
     [Google Scholar]
  6. HirotaT. KingB.H. Autism spectrum disorder: A review.JAMA2023329215716810.1001/jama.2022.2366136625807
     [Google Scholar]
  7. BölteS. GirdlerS. MarschikP.B. The contribution of environmental exposure to the etiology of autism spectrum disorder.Cell. Mol. Life Sci.20197671275129710.1007/s00018‑018‑2988‑430570672
     [Google Scholar]
  8. GroveJ. RipkeS. AlsT.D. MattheisenM. WaltersR.K. WonH. PallesenJ. AgerboE. AndreassenO.A. AnneyR. AwashtiS. BelliveauR. BettellaF. BuxbaumJ.D. Bybjerg-GrauholmJ. Bækvad-HansenM. CerratoF. ChambertK. ChristensenJ.H. ChurchhouseC. DellenvallK. DemontisD. De RubeisS. DevlinB. DjurovicS. DumontA.L. GoldsteinJ.I. HansenC.S. HaubergM.E. HollegaardM.V. HopeS. HowriganD.P. HuangH. HultmanC.M. KleiL. MallerJ. MartinJ. MartinA.R. MoranJ.L. NyegaardM. NærlandT. PalmerD.S. PalotieA. PedersenC.B. PedersenM.G. dPoterbaT. PoulsenJ.B. PourcainB.S. QvistP. RehnströmK. ReichenbergA. ReichertJ. RobinsonE.B. RoederK. RoussosP. SaemundsenE. SandinS. SatterstromF.K. Davey SmithG. StefanssonH. SteinbergS. StevensC.R. SullivanP.F. TurleyP. WaltersG.B. XuX. StefanssonK. GeschwindD.H. NordentoftM. HougaardD.M. WergeT. MorsO. MortensenP.B. NealeB.M. DalyM.J. BørglumA.D. Identification of common genetic risk variants for autism spectrum disorder.Nat. Genet.201951343144410.1038/s41588‑019‑0344‑830804558
     [Google Scholar]
  9. KimJ.Y. SonM.J. SonC.Y. RaduaJ. EisenhutM. GressierF. KoyanagiA. CarvalhoA.F. StubbsB. SolmiM. RaisT.B. LeeK.H. KronbichlerA. DragiotiE. ShinJ.I. Fusar-PoliP. Environmental risk factors and biomarkers for autism spectrum disorder: An umbrella review of the evidence.Lancet Psychiatry20196759060010.1016/S2215‑0366(19)30181‑631230684
     [Google Scholar]
  10. WangJ. YuJ. WangM. ZhangL. YangK. DuX. WuJ. WangX. LiF. QiuZ. Discovery and validation of novel genes in a large chinese autism spectrum disorder cohort.Biol. Psychiatry2023941079280310.1016/j.biopsych.2023.06.02537393044
     [Google Scholar]
  11. TickB. BoltonP. HappéF. RutterM. RijsdijkF. Heritability of autism spectrum disorders: A meta‐analysis of twin studies.J. Child Psychol. Psychiatry201657558559510.1111/jcpp.1249926709141
     [Google Scholar]
  12. AtladóttirH.Ó. ThorsenP. ØstergaardL. SchendelD.E. LemckeS. AbdallahM. ParnerE.T. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders.J. Autism Dev. Disord.201040121423143010.1007/s10803‑010‑1006‑y20414802
     [Google Scholar]
  13. SkogheimT.S. WeydeK.V.F. EngelS.M. AaseH. SurénP. ØieM.G. BieleG. Reichborn-KjennerudT. CaspersenI.H. HornigM. HaugL.S. VillangerG.D. Metal and essential element concentrations during pregnancy and associations with autism spectrum disorder and attention-deficit/hyperactivity disorder in children.Environ. Int.202115210646810.1016/j.envint.2021.10646833765546
     [Google Scholar]
  14. AtkinsH. Stem cell transplantation to treat multiple sclerosis.JAMA2019321215315510.1001/jama.2018.2077730644971
     [Google Scholar]
  15. ChristodoulouM.V. PetkouE. AtzemoglouN. GkorlaE. KaramitrouA. SimosY.V. BellosS. BekiariC. KouklisP. KonitsiotisS. VezyrakiP. PeschosD. TsamisK.I. Cell replacement therapy with stem cells in multiple sclerosis, a systematic review.Hum. Cell202337195310.1007/s13577‑023‑01006‑137985645
     [Google Scholar]
  16. HuangL. FuC. XiongF. HeC. WeiQ. Stem cell therapy for spinal cord injury.Cell Transplant.202130096368972198926610.1177/096368972198926633559479
     [Google Scholar]
  17. MazziniL. VescoviA. CantelloR. GelatiM. VercelliA. Stem cells therapy for ALS.Expert Opin. Biol. Ther.201616218719910.1517/14712598.2016.111651626558293
     [Google Scholar]
  18. Villarreal-MartínezL. González-MartínezG. Sáenz-FloresM. Bautista-GómezA.J. González-MartínezA. Ortiz-CastilloM. Robles-SáenzD.A. Garza-LópezE. Stem cell therapy in the treatment of patients with autism spectrum disorder: A systematic review and meta-analysis.Stem Cell Rev. Rep.202218115516410.1007/s12015‑021‑10257‑034515938
     [Google Scholar]
  19. DoneganJ.J. LodgeD.J. Stem cells for improving the treatment of neurodevelopmental disorders.Stem Cells Dev.202029171118113010.1089/scd.2019.026532008442
     [Google Scholar]
  20. ChefferA. FlitschL.J. KrutenkoT. RödererP. SokhranyaevaL. IefremovaV. HajoM. PeitzM. SchwarzM.K. BrüstleO. Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction.Mol. Autism20201119910.1186/s13229‑020‑00383‑w33308283
     [Google Scholar]
  21. ZakrzewskiW. DobrzyńskiM. SzymonowiczM. RybakZ. Stem cells: Past, present, and future.Stem Cell Res. Ther.20191016810.1186/s13287‑019‑1165‑530808416
     [Google Scholar]
  22. DoneganJ.J. BoleyA.M. LodgeD.J. Embryonic stem cell transplants as a therapeutic strategy in a rodent model of autism.Neuropsychopharmacology20184381789179810.1038/s41386‑018‑0021‑029453447
     [Google Scholar]
  23. ShroffG. GuptaR. Human embryonic stem cells in the treatment of patients with spinal cord injury.Ann. Neurosci.201522420821610.5214/ans.0972.7531.22040426526627
     [Google Scholar]
  24. BiermannM. ReyaT. Hematopoietic stem cells and regeneration.Cold Spring Harb. Perspect. Biol.2022148a04077410.1101/cshperspect.a04077434750175
     [Google Scholar]
  25. ChenQ. ShouP. ZhengC. JiangM. CaoG. YangQ. CaoJ. XieN. VelletriT. ZhangX. XuC. ZhangL. YangH. HouJ. WangY. ShiY. Fate decision of mesenchymal stem cells: Adipocytes or osteoblasts?Cell Death Differ.20162371128113910.1038/cdd.2015.16826868907
     [Google Scholar]
  26. NaritaT. SuzukiK. Bone marrow-derived mesenchymal stem cells for the treatment of heart failure.Heart Fail. Rev.2015201536810.1007/s10741‑014‑9435‑x24862087
     [Google Scholar]
  27. ConeA.S. YuanX. SunL. DukeL.C. VreonesM.P. CarrierA.N. KenyonS.M. CarverS.R. BenthemS.D. StimmellA.C. MoseleyS.C. HikeD. GrantS.C. WilberA.A. OlceseJ.M. MeckesD.G. Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer’s disease-like phenotypes in a preclinical mouse model.Theranostics202111178129814210.7150/thno.6206934373732
     [Google Scholar]
  28. LinH. SohnJ. ShenH. LanghansM.T. TuanR.S. Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing.Biomaterials20192039611010.1016/j.biomaterials.2018.06.02629980291
     [Google Scholar]
  29. MatsumuraT. KamiM. YamaguchiT. YujiK. KusumiE. TaniguchiS. TakahashiS. OkadaM. SakamakiH. AzumaH. TakanashiM. KodoH. KaiS. Inoue-NagamuraT. KatoK. KatoS. Allogeneic cord blood transplantation for adult acute lymphoblastic leukemia: Retrospective survey involving 256 patients in Japan.Leukemia20122671482148610.1038/leu.2012.1122290068
     [Google Scholar]
  30. HsuJ. ArtzA. MayerS.A. GuarnerD. BishopM.R. Reich-SlotkyR. SmithS.M. GreenbergJ. KlineJ. FerranteR. PhillipsA.A. GergisU. LiuH. StockW. CushingM. ShoreT.B. van BesienK. Combined haploidentical and umbilical cord blood allogeneic stem cell transplantation for high-risk lymphoma and chronic lymphoblastic leukemia.Biol. Blood Marrow Transplant.201824235936510.1016/j.bbmt.2017.10.04029128555
     [Google Scholar]
  31. DamienP. AllanD.S. Regenerative therapy and immune modulation using umbilical cord blood–derived cells.Biol. Blood Marrow Transplant.20152191545155410.1016/j.bbmt.2015.05.02226079441
     [Google Scholar]
  32. ZhangY. PanY. LiuY. LiX. TangL. DuanM. LiJ. ZhangG. Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition.Stem Cell Res. Ther.202112143410.1186/s13287‑021‑02517‑034344478
     [Google Scholar]
  33. DawsonG. SunJ.M. DavlantisK.S. MuriasM. FranzL. TroyJ. SimmonsR. Sabatos-DeVitoM. DurhamR. KurtzbergJ. Autologous cord blood infusions are safe and feasible in young children with autism spectrum disorder: Results of a single-center phase I open-label trial.Stem Cells Transl. Med.2017651332133910.1002/sctm.16‑047428378499
     [Google Scholar]
  34. ZukP.A. ZhuM. MizunoH. HuangJ. FutrellJ.W. KatzA.J. BenhaimP. LorenzH.P. HedrickM.H. Multilineage cells from human adipose tissue: Implications for cell-based therapies.Tissue Eng.20017221122810.1089/10763270130006285911304456
     [Google Scholar]
  35. BacakovaL. ZarubovaJ. TravnickovaM. MusilkovaJ. PajorovaJ. SlepickaP. KasalkovaN.S. SvorcikV. KolskaZ. MotarjemiH. MolitorM. Stem cells: Their source, potency and use in regenerative therapies with focus on adipose-derived stem cells – A review.Biotechnol. Adv.20183641111112610.1016/j.biotechadv.2018.03.01129563048
     [Google Scholar]
  36. GonzálezM.A. Gonzalez-ReyE. RicoL. BüscherD. DelgadoM. Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses.Gastroenterology2009136397898910.1053/j.gastro.2008.11.04119135996
     [Google Scholar]
  37. HaS. ParkH. MahmoodU. RaJ.C. SuhY.H. ChangK.A. Human adipose-derived stem cells ameliorate repetitive behavior, social deficit and anxiety in a VPA-induced autism mouse model.Behav. Brain Res.201731747948410.1016/j.bbr.2016.10.00427717813
     [Google Scholar]
  38. MinQ. YangL. TianH. TangL. XiaoZ. ShenJ. Immunomodulatory mechanism and potential application of dental pulp-derived stem cells in immune-mediated diseases.Int. J. Mol. Sci.2023249806810.3390/ijms2409806837175774
     [Google Scholar]
  39. ApelC. ForlenzaO.V. de PaulaV.J.R. TalibL.L. DeneckeB. EduardoC.P. GattazW.F. The neuroprotective effect of dental pulp cells in models of Alzheimer’s and Parkinson’s disease.J. Neural Transm.20091161717810.1007/s00702‑008‑0135‑318972063
     [Google Scholar]
  40. ZhaoL. LiY. KouX. ChenB. CaoJ. LiJ. ZhangJ. WangH. ZhaoJ. ShiS. Stem cells from human exfoliated deciduous teeth ameliorate autistic-like behaviors of SHANK3 mutant beagle dogs.Stem Cells Transl. Med.202211777878910.1093/stcltm/szac02835608372
     [Google Scholar]
  41. McDonaldC.A. PayneN.L. SunG. MoussaL. SiatskasC. LimR. WallaceE.M. JenkinG. BernardC.C.A. Immunosuppressive potential of human amnion epithelial cells in the treatment of experimental autoimmune encephalomyelitis.J. Neuroinflammation201512111210.1186/s12974‑015‑0322‑826036872
     [Google Scholar]
  42. ZhangR. CaiY. XiaoR. ZhongH. LiX. GuoL. XuH. FanX. Human amniotic epithelial cell transplantation promotes neurogenesis and ameliorates social deficits in BTBR mice.Stem Cell Res. Ther.201910115310.1186/s13287‑019‑1267‑031151403
     [Google Scholar]
  43. LancasterM.A. KnoblichJ.A. Generation of cerebral organoids from human pluripotent stem cells.Nat. Protoc.20149102329234010.1038/nprot.2014.15825188634
     [Google Scholar]
  44. HuangW.K. WongS.Z.H. PatherS.R. NguyenP.T.T. ZhangF. ZhangD.Y. ZhangZ. LuL. FangW. ChenL. Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells.Cell Stem Cell20212891657167010.1016/j.stem.2021.04.00633961804
     [Google Scholar]
  45. DongX. XuS.B. ChenX. TaoM. TangX.Y. FangK.H. XuM. PanY. ChenY. HeS. LiuY. Human cerebral organoids establish subcortical projections in the mouse brain after transplantation.Mol. Psychiatry20212672964297610.1038/s41380‑020‑00910‑433051604
     [Google Scholar]
  46. AbudE.M. RamirezR.N. MartinezE.S. HealyL.M. NguyenC.H.H. NewmanS.A. YerominA.V. ScarfoneV.M. MarshS.E. FimbresC. CarawayC.A. FoteG.M. MadanyA.M. AgrawalA. KayedR. GylysK.H. CahalanM.D. CummingsB.J. AntelJ.P. MortazaviA. CarsonM.J. PoonW.W. Blurton-JonesM. iPSC-derived human microglia-like cells to study neurological diseases.Neuron2017942278293.e910.1016/j.neuron.2017.03.04228426964
     [Google Scholar]
  47. MartonR.M. MiuraY. SloanS.A. LiQ. RevahO. LevyR.J. HuguenardJ.R. PașcaS.P. Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures.Nat. Neurosci.201922348449110.1038/s41593‑018‑0316‑930692691
     [Google Scholar]
  48. SloanS.A. DarmanisS. HuberN. KhanT.A. BireyF. CanedaC. ReimerR. QuakeS.R. BarresB.A. PaşcaS.P. Human astrocyte maturation captured in 3D cerebral cortical spheroids derived from pluripotent stem cells.Neuron2017954779790.e610.1016/j.neuron.2017.07.03528817799
     [Google Scholar]
  49. CampJ.G. BadshaF. FlorioM. KantonS. GerberT. Wilsch-BräuningerM. LewitusE. SykesA. HeversW. LancasterM. KnoblichJ.A. LachmannR. PääboS. HuttnerW.B. TreutleinB. Human cerebral organoids recapitulate gene expression programs of fetal neocortex development.Proc. Natl. Acad. Sci. USA201511251156721567710.1073/pnas.152076011226644564
     [Google Scholar]
  50. KimS.W. WooH.J. KimE.H. KimH.S. SuhH.N. KimS.H. SongJ.J. WulansariN. KangM. ChoiS.Y. ChoiS.J. JangW.H. LeeJ. KimK.H. LeeW. KimS.H. YangJ. KyungJ. LeeH.S. ParkS.M. ChangM.Y. LeeS.H. Neural stem cells derived from human midbrain organoids as a stable source for treating Parkinson’s disease: Midbrain organoid-NSCs (Og-NSC) as a stable source for PD treatment.Prog. Neurobiol.202120410208610.1016/j.pneurobio.2021.10208634052305
     [Google Scholar]
  51. XiangA.H. WangX. MartinezM.P. WalthallJ.C. CurryE.S. PageK. BuchananT.A. ColemanK.J. GetahunD. Association of maternal diabetes with autism in offspring.JAMA2015313141425143410.1001/jama.2015.270725871668
     [Google Scholar]
  52. WangX. LuJ. XieW. LuX. LiangY. LiM. WangZ. HuangX. TangM. PfaffD.W. TangY.P. YaoP. Maternal diabetes induces autism-like behavior by hyperglycemia-mediated persistent oxidative stress and suppression of superoxide dismutase 2.Proc. Natl. Acad. Sci. USA201911647237432375210.1073/pnas.191262511631685635
     [Google Scholar]
  53. ZengJ. LiangY. SunR. HuangS. WangZ. XiaoL. LuJ. YuH. YaoP. Hematopoietic stem cell transplantation ameliorates maternal diabetes-mediated gastrointestinal symptoms and autism-like behavior in mouse offspring.Ann. N. Y. Acad. Sci.2022151219811310.1111/nyas.1476635220596
     [Google Scholar]
  54. ChenQ. DeisterC.A. GaoX. GuoB. Lynn-JonesT. ChenN. WellsM.F. LiuR. GoardM.J. DimidschsteinJ. FengS. ShiY. LiaoW. LuZ. FishellG. MooreC.I. FengG. Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD.Nat. Neurosci.202023452053210.1038/s41593‑020‑0598‑632123378
     [Google Scholar]
  55. Al-OtaishH. Al-AyadhiL. BjørklundG. ChirumboloS. UrbinaM.A. El-AnsaryA. Relationship between absolute and relative ratios of glutamate, glutamine and GABA and severity of autism spectrum disorder.Metab. Brain Dis.201833384385410.1007/s11011‑018‑0186‑629397522
     [Google Scholar]
  56. El-AnsaryA. Al-AyadhiL. GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders.J. Neuroinflammation20141118910.1186/s12974‑014‑0189‑025407263
     [Google Scholar]
  57. YipJ. SoghomonianJ.J. BlattG.J. Increased GAD67 mRNA expression in cerebellar interneurons in autism: Implications for Purkinje cell dysfunction.J. Neurosci. Res.200886352553010.1002/jnr.2152017918742
     [Google Scholar]
  58. YipJ. SoghomonianJ.J. BlattG.J. Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: An in situ hybridization study.Autism Res.200921505910.1002/aur.6219358307
     [Google Scholar]
  59. LionelA.C. TammimiesK. VaagsA.K. RosenfeldJ.A. AhnJ.W. MericoD. NoorA. RunkeC.K. PillalamarriV.K. CarterM.T. GazzelloneM.J. ThiruvahindrapuramB. FagerbergC. LaulundL.W. PellecchiaG. LamoureuxS. DeshpandeC. Clayton-SmithJ. WhiteA.C. LeatherS. TrounceJ. Melanie BedfordH. HatchwellE. EisP.S. YuenR.K. WalkerS. UddinM. GeraghtyM.T. NikkelS.M. TomiakE.M. FernandezB.A. SoreniN. CrosbieJ. ArnoldP.D. SchacharR.J. RobertsW. PatersonA.D. SoJ. SzatmariP. ChryslerC. Woodbury-SmithM. Brian LowryR. ZwaigenbaumL. MandyamD. WeiJ. MacdonaldJ.R. HoweJ.L. NalpathamkalamT. WangZ. TolsonD. CobbD.S. WilksT.M. SorensenM.J. BaderP.I. AnY. WuB.L. MusumeciS.A. RomanoC. PostorivoD. NardoneA.M. MonicaM.D. ScaranoG. ZoccanteL. NovaraF. ZuffardiO. CicconeR. AntonaV. CarellaM. ZelanteL. CavalliP. PoggianiC. CavallariU. ArgiropoulosB. ChernosJ. Brasch-AndersenC. SpeevakM. FicheraM. OgilvieC.M. ShenY. HodgeJ.C. TalkowskiM.E. StavropoulosD.J. MarshallC.R. SchererS.W. Disruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes.Hum. Mol. Genet.201423102752276810.1093/hmg/ddt66924381304
     [Google Scholar]
  60. ZhuJ.W. ZouM.M. LiY.F. ChenW.J. LiuJ.C. ChenH. FangL.P. ZhangY. WangZ.T. ChenJ.B. HuangW. LiS. JiaW.Q. WangQ.Q. ZhenX.C. LiuC.F. LiS. XiaoZ.C. XuG.Q. SchwambornJ.C. SchachnerM. MaQ.H. XuR.X. Absence of TRIM32 leads to reduced gabaergic interneuron generation and autism-like behaviors in mice via suppressing mTOR signaling.Cereb. Cortex20203053240325810.1093/cercor/bhz30631828304
     [Google Scholar]
  61. AndrzejewskaA. DabrowskaS. LukomskaB. JanowskiM. Mesenchymal stem cells for neurological disorders.Adv. Sci.202187200294410.1002/advs.20200294433854883
     [Google Scholar]
  62. NoshadianM. RagerdiK.I. Asadi-GolshanR. ZariniD. GhafariN. ZahediE. PasbakhshP. Benefits of bone marrow mesenchymal stem cells compared to their conditioned medium in valproic acid-induced autism in rats.Mol. Biol. Rep.202451135310.1007/s11033‑024‑09292‑038401030
     [Google Scholar]
  63. GobshtisN. TfilinM. WolfsonM. FraifeldV.E. TurgemanG. Transplantation of mesenchymal stem cells reverses behavioural deficits and impaired neurogenesis caused by prenatal exposure to valproic acid.Oncotarget2017811174431745210.18632/oncotarget.1524528407680
     [Google Scholar]
  64. Segal-GavishH. KarvatG. BarakN. BarzilayR. GanzJ. EdryL. AharonyI. OffenD. KimchiT. Mesenchymal stem cell transplantation promotes neurogenesis and ameliorates autism related behaviors in BTBR mice.Autism Res201691173210.1002/aur.153026257137
     [Google Scholar]
  65. JingyiL. LinW. YuanC. LinglingZ. QianqianJ. AnlongX. YansongG. Intravenous transplantation of bone marrow-derived mesenchymal stem cells improved behavioral deficits and altered fecal microbiota composition of BTBR mice.Life Sci.202433612233010.1016/j.lfs.2023.12233038065352
     [Google Scholar]
  66. PeretsN. Segal-GavishH. GothelfY. BarzilayR. BarhumY. AbramovN. HertzS. MorozovD. LondonM. OffenD. Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism.Behav. Brain Res.201733125426010.1016/j.bbr.2017.03.04728392323
     [Google Scholar]
  67. ChenX. ChenA. WeiJ. HuangY. DengJ. ChenP. YanY. LinM. ChenL. ZhangJ. HuangZ. ZengX. GongC. ZhengX. Dexmedetomidine alleviates cognitive impairment by promoting hippocampal neurogenesis via BDNF/TrkB/CREB signaling pathway in hypoxic–ischemic neonatal rats.CNS Neurosci. Ther.2024301e1448610.1111/cns.1448637830170
     [Google Scholar]
  68. QuesseveurG. DavidD.J. GaillardM.C. PlaP. WuM.V. NguyenH.T. NicolasV. AureganG. DavidI. DranovskyA. HantrayeP. HenR. GardierA.M. DéglonN. GuiardB.P. BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities.Transl. Psychiatry201334e25310.1038/tp.2013.3023632457
     [Google Scholar]
  69. LiuH. XueX. ShiH. QiL. GongD. Osthole upregulates BDNF to enhance adult hippocampal neurogenesis in APP/PS1 transgenic mice.Biol. Pharm. Bull.201538101439144910.1248/bpb.b15‑0001326424009
     [Google Scholar]
  70. PeretsN. HertzS. LondonM. OffenD. Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice.Mol. Autism2018915710.1186/s13229‑018‑0240‑630479733
     [Google Scholar]
  71. PeretsN. OronO. HermanS. ElliottE. OffenD. Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B.Mol. Autism20201116510.1186/s13229‑020‑00366‑x32807217
     [Google Scholar]
  72. FuY. ZhangY. LiuR. XuM. XieJ. ZhangX. XieG. HanY. ZhangX.M. ZhangW. ZhangJ. ZhangJ. Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice.J. Nanobiotechnol.20242216610.1186/s12951‑024‑02338‑238368393
     [Google Scholar]
  73. LiangY. DuanL. XuX. LiX. LiuM. ChenH. LuJ. XiaJ. Mesenchymal stem cell-derived exosomes for treatment of autism spectrum disorder.ACS Appl. Bio Mater.2020396384639310.1021/acsabm.0c0083135021769
     [Google Scholar]
  74. QinQ. ShanZ. XingL. JiangY. LiM. FanL. ZengX. MaX. ZhengD. WangH. WangH. LiuH. LiangS. WuL. LiangS. Synergistic effect of mesenchymal stem cell-derived extracellular vesicle and miR-137 alleviates autism-like behaviors by modulating the NF-κB pathway.J. Transl. Med.202422144610.1186/s12967‑024‑05257‑w38741170
     [Google Scholar]
  75. WangJ. LiuX. LuH. JiangC. CuiX. YuL. FuX. LiQ. WangJ. CXCR4+CD45− BMMNC subpopulation is superior to unfractionated BMMNCs for protection after ischemic stroke in mice.Brain Behav. Immun.2015459810810.1016/j.bbi.2014.12.01525526817
     [Google Scholar]
  76. NguyenQ.T. ThanhL.N. HoangV.T. PhanT.T.K. HekeM. HoangD.M. Bone marrow-derived mononuclear cells in the treatment of neurological diseases: Knowns and unknowns.Cell. Mol. Neurobiol.20234373211325010.1007/s10571‑023‑01377‑x37356043
     [Google Scholar]
  77. SavitzS.I. MisraV. KasamM. JunejaH. CoxC.S. AldermanS. AisikuI. KarS. GeeA. GrottaJ.C. Intravenous autologous bone marrow mononuclear cells for ischemic stroke.Ann. Neurol.2011701596910.1002/ana.2245821786299
     [Google Scholar]
  78. SharmaA.K. SaneH.M. KulkarniP.P. GokulchandranN. BijuH. BadheP.B. Autologous bone marrow mononuclear cell transplantation in patients with chronic traumatic brain injury- A clinical study.Cell Regen.202091310.1186/s13619‑020‑00043‑732588151
     [Google Scholar]
  79. SharmaA.K. SaneH.M. ParanjapeA.A. GokulchandranN. NagrajanA. D’saM. BadheP.B. The effect of autologous bone marrow mononuclear cell transplantation on the survival duration in Amyotrophic Lateral Sclerosis - a retrospective controlled study.Am. J. Stem Cells201541506525973331
     [Google Scholar]
  80. SharmaA. SaneH. GokulchandranN. KulkarniP. JoseA. NairV. DasR. LakhanpalV. BadheP. Intrathecal transplantation of autologous bone marrow mononuclear cells in patients with sub-acute and chronic spinal cord injury: An open-label study.Int. J. Health Sci.2020142243232206057
     [Google Scholar]
  81. SharmaA. GokulchandranN. SaneH. NagrajanA. ParanjapeA. KulkarniP. ShettyA. MishraP. KaliM. BijuH. BadheP. Autologous bone marrow mononuclear cell therapy for autism: An open label proof of concept study.Stem Cells Int.2013201362387510.1155/2013/62387524062774
     [Google Scholar]
  82. SharmaA. BadheP. An improved case of autism as revealed by PET CT scan in patient transplanted with autologous bone marrow derived mononuclear cells.J. Stem Cell Res. Ther.2013321410.4172/2157‑7633.1000139
     [Google Scholar]
  83. SharmaA Intrathecal autologous bone marrow mononuclear cell transplantation in a case of adult autism.Autism OA2013321510.4172/2165‑7890.1000113
     [Google Scholar]
  84. SharmaA. GokulchandranN. ShettyA. SaneH. KulkarniP. BadheP. Autologous bone marrow mononuclear cells may be explored as a novel potential therapeutic option for autism.J. Clin. Case Rep.2013371510.4172/2165‑7920.1000282
     [Google Scholar]
  85. AlokS. NandiniG. HemangiS. AvantikaP. AkshataS. HemaB. PoojaK. PrernaB. Amelioration of autism by autologous bone marrow mononuclear cells and neurorehabilitation: A case report.Am. J. Med. Case Rep.201531030430910.12691/ajmcr‑3‑10‑1
     [Google Scholar]
  86. PoojaK. A case of autism showing clinical improvements after cellular therapy along with PET CT evidence.J. Stem Cell Res. Ther.20172410.15406/jsrt.2017.02.00070
     [Google Scholar]
  87. SharmaA. GokulchandranN. SaneH. KulkarniP. NivinsS. MaheshwariM. BadheP.J.I.B. Therapeutic effects of cellular therapy in a case of adult autism spectrum of disorder.Int Biol Biomed J20184298103
     [Google Scholar]
  88. MaricD.M. PapicV. RadomirM. StanojevicI. SokolovacI. MilosavljevicK. MaricD.L. AbazovicD. Autism treatment with stem cells: A case report.Eur. Rev. Med. Pharmacol. Sci.202024158075808010.26355/eurrev_202008_2249132767334
     [Google Scholar]
  89. NguyenT.L. NguyenH.P. NgoM.D. BuiV.A. DamP.T.M. BuiH.T.P. NgoD.V. TranK.T. DangT.T.T. DuongB.D. NguyenP.A.T. ForsythN. HekeM. Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder.Stem Cells Transl. Med.2021101142610.1002/sctm.20‑010232902182
     [Google Scholar]
  90. SharmaA.K. GokulchandranN. KulkarniP.P. SaneH.M. SharmaR. JoseA. BadheP.B. Cell transplantation as a novel therapeutic strategy for autism spectrum disorders: A clinical study.Am. J. Stem Cells2020958910033489466
     [Google Scholar]
  91. Villarreal-MartinezL. MartÍnez-GarzaL.E. Rodriguez-SanchezI.P. Alvarez-VillalobosN. Guzman-GallardoF. Pope-SalazarS. Salinas-SilvaC. Cepeda-CepedaM.G. Garza-BedollaA. Dominguez-VarelaI.A. Villarreal-MartinezD.Z. Treviño-VillarrealJ.H. Gomez-AlmaguerD. Correlation between CD133+ stem cells and clinical improvement in patients with autism spectrum disorders treated with intrathecal bone marrow-derived mononuclear cells.Innov. Clin. Neurosci.2022194-6788635958968
     [Google Scholar]
  92. SharifzadehN. GhasemiA. TavakolA.J. MoharariF. SoltanifarA. TalaeiA. PouryousofH.R. NahidiM. Fayyazi BordbarM.R. ZiaeeM. Intrathecal autologous bone marrow stem cell therapy in children with autism: A randomized controlled trial.Asia-Pac. Psychiatry2021132e1244510.1111/appy.1244533150703
     [Google Scholar]
  93. ZakeriniaM. KamgarpourA. NematiH. ZareH.R. GhasemfarM. RezvaniA.R. KarimiM. NouraniK.H. DehghaniM. VojdaniR. HaghighatS. NamdariN. RekabpoorJ. TavazoM. AmirghofranS. AmirghofranZ. YosefipourG.A. RamziM. Intrathecal autologous bone marrow-derived hematopoietic stem cell therapy in neurological diseases.Int. J. Organ Transplant. Med.20189415716730863518
     [Google Scholar]
  94. KobiniaG.S. ZaknunJ.J. PabingerC. LakyB. Case report: Autologous bone marrow derived intrathecal stem cell transplant for autistic children - A report of four cases and literature review.Front Pediatr.2021962018810.3389/fped.2021.62018834692600
     [Google Scholar]
  95. CroonenberghsJ. BosmansE. DeboutteD. KenisG. MaesM. Activation of the inflammatory response system in autism.Neuropsychobiology20024511610.1159/00004866511803234
     [Google Scholar]
  96. JyonouchiH. SunS. LeH. Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression.J. Neuroimmunol.20011201-217017910.1016/S0165‑5728(01)00421‑011694332
     [Google Scholar]
  97. CareagaM. RogersS. HansenR.L. AmaralD.G. Van de WaterJ. AshwoodP. Immune endophenotypes in children with autism spectrum disorder.Biol. Psychiatry201781543444110.1016/j.biopsych.2015.08.03626493496
     [Google Scholar]
  98. BradstreetJ.J. SychN. AntonucciN. KlunnikM. IvankovaO. MatyashchukI. DemchukM. SiniscalcoD. Efficacy of fetal stem cell transplantation in autism spectrum disorders: An open-labeled pilot study.Cell Transplant.2014231_suppl10511210.3727/096368914X68491625302490
     [Google Scholar]
  99. LvY.T. ZhangY. LiuM. QiuwaxiJ. AshwoodP. ChoS.C. HuanY. GeR.C. ChenX.W. WangZ.J. KimB.J. HuX. Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism.J. Transl. Med.201311119610.1186/1479‑5876‑11‑19623978163
     [Google Scholar]
  100. DawsonG. SunJ.M. BakerJ. CarpenterK. ComptonS. DeaverM. FranzL. HeilbronN. HeroldB. HorriganJ. HowardJ. KosinskiA. MajorS. MuriasM. PageK. PrasadV.K. Sabatos-DeVitoM. SanfilippoF. SikichL. SimmonsR. SongA. VermeerS. Waters-PickB. TroyJ. KurtzbergJ. A phase II randomized clinical trial of the safety and efficacy of intravenous umbilical cord blood infusion for treatment of children with autism spectrum disorder.J. Pediatr.2020222164173.e510.1016/j.jpeds.2020.03.01132444220
     [Google Scholar]
  101. MuriasM. MajorS. ComptonS. ButtingerJ. SunJ.M. KurtzbergJ. DawsonG. Electrophysiological biomarkers predict clinical improvement in an open-label trial assessing efficacy of autologous umbilical cord blood for treatment of autism.Stem Cells Transl. Med.201871178379110.1002/sctm.18‑009030070044
     [Google Scholar]
  102. ChezM. LepageC. PariseC. Dang-ChuA. HankinsA. CarrollM. Safety and observations from a placebo-controlled, crossover study to assess use of autologous umbilical cord blood stem cells to improve symptoms in children with autism.Stem Cells Transl. Med.20187433334110.1002/sctm.17‑004229405603
     [Google Scholar]
  103. PetrivT. TatarchukM. SkuratovA. RybachukO. TsymbaliukV. Safety of combined autistic spectrum disorders treatment with umbilical cord mesenchymal stem cells application: Clinical investigation.Stem Cells Transl. Med.202110S1S1010.1002/sct3.1301735599373
     [Google Scholar]
  104. SunJ.M. SongA.W. CaseL.E. MikatiM.A. GustafsonK.E. SimmonsR. GoldsteinR. PetryJ. McLaughlinC. Waters-PickB. ChenL.W. WeaseS. BlackwellB. WorleyG. TroyJ. KurtzbergJ. Effect of autologous cord blood infusion on motor function and brain connectivity in young children with cerebral palsy: A randomized, placebo-controlled trial.Stem Cells Transl. Med.20176122071207810.1002/sctm.17‑010229080265
     [Google Scholar]
  105. AlaviO. AlizadehA. DehghaniF. AlipourH. TanidehN. Anti-inflammatory effects of umbilical cord mesenchymal stem cell and autologous conditioned serum on oligodendrocyte, astrocyte, and microglial specific gene in cuprizone animal model.Curr. Stem Cell Res. Ther.2024191718210.2174/1574888X1866623022810273136852798
     [Google Scholar]
  106. CarpenterK.L.H. MajorS. TallmanC. ChenL.W. FranzL. SunJ. KurtzbergJ. SongA. DawsonG. White matter tract changes associated with clinical improvement in an open-label trial assessing autologous umbilical cord blood for treatment of young children with autism.Stem Cells Transl. Med.20198213814710.1002/sctm.18‑025130620122
     [Google Scholar]
  107. SimhalA.K. CarpenterK.L.H. NadeemS. KurtzbergJ. SongA. TannenbaumA. SapiroG. DawsonG. Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature.Sci. Rep.20201011081910.1038/s41598‑020‑67474‑932616759
     [Google Scholar]
  108. ChaB. KwakH. BangJ.I. JangS.J. SuhM.R. ChoiJ.I. KimM. Safety and efficacy of allogeneic umbilical cord blood therapy for global development delay and intellectual disability.Stem Cells Dev.2023327-817017910.1089/scd.2022.025236734415
     [Google Scholar]
  109. SunJ.M. DawsonG. FranzL. HowardJ. McLaughlinC. KistlerB. Waters-PickB. MeadowsN. TroyJ. KurtzbergJ. Infusion of human umbilical cord tissue mesenchymal stromal cells in children with autism spectrum disorder.Stem Cells Transl. Med.20209101137114610.1002/sctm.19‑043432531111
     [Google Scholar]
  110. AignerS. HeckelT. ZhangJ.D. AndreaeL.C. JagasiaR. Human pluripotent stem cell models of autism spectrum disorder: Emerging frontiers, opportunities, and challenges towards neuronal networks in a dish.Psychopharmacology201423161089110410.1007/s00213‑013‑3332‑124232378
     [Google Scholar]
  111. MarchettoM.C.N. CarromeuC. AcabA. YuD. YeoG.W. MuY. ChenG. GageF.H. MuotriA.R. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.Cell2010143452753910.1016/j.cell.2010.10.01621074045
     [Google Scholar]
  112. TeliasM. Molecular mechanisms of synaptic dysregulation in fragile x syndrome and autism spectrum disorders.Front. Mol. Neurosci.2019125110.3389/fnmol.2019.0005130899214
     [Google Scholar]
  113. DeneaultE. FaheemM. WhiteS.H. RodriguesD.C. SunS. WeiW. PieknaA. ThompsonT. HoweJ.L. ChalilL. KwanV. WalkerS. PasceriP. RothF.P. YuenR.K.C. SinghK.K. EllisJ. SchererS.W. CNTN5 - /+ or EHMT2 - /+ human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks.eLife20198e4009210.7554/eLife.4009230747104
     [Google Scholar]
  114. MartinP. WaghV. ReisS.A. ErdinS. BeauchampR.L. ShaikhG. TalkowskiM. ThieleE. SheridanS.D. HaggartyS.J. RameshV. TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling.Mol. Autism2020111210.1186/s13229‑019‑0311‑331921404
     [Google Scholar]
  115. WangM. WeiP.C. LimC.K. GallinaI.S. MarshallS. MarchettoM.C. AltF.W. GageF.H. Increased neural progenitor proliferation in a hiPSC model of autism induces replication stress-associated genome instability.Cell Stem Cell2020262221233.e610.1016/j.stem.2019.12.01332004479
     [Google Scholar]
  116. MarchettoM.C. BelinsonH. TianY. FreitasB.C. FuC. VadodariaK.C. Beltrao-BragaP.C. TrujilloC.A. MendesA.P.D. PadmanabhanK. NunezY. OuJ. GhoshH. WrightR. BrennandK.J. PierceK. EichenfieldL. PramparoT. EylerL.T. BarnesC.C. CourchesneE. GeschwindD.H. GageF.H. Wynshaw-BorisA. MuotriA.R. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals.Mol. Psychiatry201722682083510.1038/mp.2016.9527378147
     [Google Scholar]
  117. AdhyaD. SwarupV. NagyR. DutanL. ShumC. Valencia-AlarcónE.P. JozwikK.M. MendezM.A. HorderJ. LothE. NowosiadP. LeeI. SkuseD. FlinterF.A. MurphyD. McAlonanG. GeschwindD.H. PriceJ. CarrollJ. SrivastavaD.P. Baron-CohenS. Atypical neurogenesis in induced pluripotent stem cells from autistic individuals.Biol. Psychiatry202189548649610.1016/j.biopsych.2020.06.01432826066
     [Google Scholar]
  118. AvazzadehS. McDonaghK. ReillyJ. WangY. BoomkampS.D. McInerneyV. KrawczykJ. FitzgeraldJ. FeerickN. O’SullivanM. JalaliA. FormanE.B. LynchS.A. EnnisS. CosemansN. PeetersH. DockeryP. O’BrienT. QuinlanL.R. GallagherL. ShenS. Increased Ca 2+ signaling in NRXN1α +/− neurons derived from ASD induced pluripotent stem cells.Mol. Autism20191015210.1186/s13229‑019‑0303‑331893021
     [Google Scholar]
  119. RussoF.B. FreitasB.C. PignatariG.C. FernandesI.R. SebatJ. MuotriA.R. Beltrão-BragaP.C.B. Modeling the interplay between neurons and astrocytes in autism using human induced pluripotent stem cells.Biol. Psychiatry201883756957810.1016/j.biopsych.2017.09.02129129319
     [Google Scholar]
  120. LancasterM.A. RennerM. MartinC.A. WenzelD. BicknellL.S. HurlesM.E. HomfrayT. PenningerJ.M. JacksonA.P. KnoblichJ.A. Cerebral organoids model human brain development and microcephaly.Nature2013501746737337910.1038/nature1251723995685
     [Google Scholar]
  121. PaulsenB. VelascoS. KedaigleA.J. PigoniM. QuadratoG. DeoA.J. AdiconisX. UzquianoA. SartoreR. YangS.M. SimmonsS.K. SymvoulidisP. KimK. TsafouK. PoduryA. AbbateC. TucewiczA. SmithS.N. AlbaneseA. BarrettL. SanjanaN.E. ShiX. ChungK. LageK. BoydenE.S. RegevA. LevinJ.Z. ArlottaP. Autism genes converge on asynchronous development of shared neuron classes.Nature2022602789626827310.1038/s41586‑021‑04358‑635110736
     [Google Scholar]
  122. MarianiJ. CoppolaG. ZhangP. AbyzovA. ProviniL. TomasiniL. AmenduniM. SzekelyA. PalejevD. WilsonM. GersteinM. GrigorenkoE.L. ChawarskaK. PelphreyK.A. HoweJ.R. VaccarinoF.M. FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders.Cell2015162237539010.1016/j.cell.2015.06.03426186191
     [Google Scholar]
  123. JourdonA. WuF. MarianiJ. CapautoD. NortonS. TomasiniL. AmiriA. SuvakovM. SchreinerJ.D. JangY. PandaA. NguyenC.K. CummingsE.M. HanG. PowellK. SzekelyA. McPartlandJ.C. PelphreyK. ChawarskaK. VentolaP. AbyzovA. VaccarinoF.M. Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis.Nat. Neurosci.20232691505151510.1038/s41593‑023‑01399‑037563294
     [Google Scholar]
  124. LiC. FleckJ.S. Martins-CostaC. BurkardT.R. ThemannJ. StuempflenM. PeerA.M. VertesyÁ. LittleboyJ.B. EskC. EllingU. KasprianG. CorsiniN.S. TreutleinB. KnoblichJ.A. Single-cell brain organoid screening identifies developmental defects in autism.Nature2023621797837338010.1038/s41586‑023‑06473‑y37704762
     [Google Scholar]
  125. WangP. MokhtariR. PedrosaE. KirschenbaumM. BayrakC. ZhengD. LachmanH.M. CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells.Mol. Autism2017811110.1186/s13229‑017‑0124‑128321286
     [Google Scholar]
  126. VillaC.E. CheroniC. DotterC.P. López-TóbonA. OliveiraB. SaccoR. YahyaA.Ç. MorandellJ. GabrieleM. TavakoliM.R. LyudchikJ. SommerC. GabittoM. DanzlJ.G. TestaG. NovarinoG. CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories.Cell Rep.202239111061510.1016/j.celrep.2022.11061535385734
     [Google Scholar]
  127. AstorkiaM. LiuY. PedrosaE.M. LachmanH.M. ZhengD. Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis of CHD8 heterozygous cerebral organoids.Heliyon20241014e3486210.1016/j.heliyon.2024.e3486239149047
     [Google Scholar]
  128. FairS.R. SchwindW. JulianD.L. BielA. GuoG. RutherfordR. RamadesikanS. WestfallJ. MillerK.E. KararoudiM.N. HickeyS.E. MosherT.M. McBrideK.L. NeinastR. FitchJ. LeeD.A. WhiteP. WilsonR.K. BedrosianT.A. KoboldtD.C. HesterM.E. Cerebral organoids containing an AUTS2 missense variant model microcephaly.Brain2023146138740410.1093/brain/awac24435802027
     [Google Scholar]
  129. FetitR. BarbatoM.I. TheilT. PrattT. PriceD.J. 16p11.2 deletion accelerates subpallial maturation and increases variability in human iPSC-derived ventral telencephalic organoids.Development20231504dev20122710.1242/dev.20122736826401
     [Google Scholar]
  130. WangY. ChiolaS. YangG. RussellC. ArmstrongC.J. WuY. SpampanatoJ. TarbotonP. UllahH.M.A. EdgarN.U. ChangA.N. HarminD.A. BocchiV.D. VezzoliE. BesussoD. CuiJ. CattaneoE. KubanekJ. ShcheglovitovA. Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes.Nat. Commun.2022131568810.1038/s41467‑022‑33364‑z36202854
     [Google Scholar]
  131. de JongJ.O. LlapashticaC. GenestineM. StraussK. ProvenzanoF. SunY. ZhuH. CorteseG.P. BrunduF. BrigattiK.W. CorneoB. MiglioriB. TomerR. KushnerS.A. KellendonkC. JavitchJ.A. XuB. MarkxS. Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder.Nat. Commun.2021121408710.1038/s41467‑021‑24358‑434471112
     [Google Scholar]
  132. WuJ. ZhangJ. ChenX. WettschurackK. QueZ. DemingB.A. Olivero-AcostaM.I. CuiN. EatonM. ZhaoY. LiS.M. SuzukiM. ChenI. XiaoT. HalurkarM.S. MandalP. YuanC. XuR. KossW.A. DuD. ChenF. WuL. YangY. Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids.Mol. Psychiatry20242982424243710.1038/s41380‑024‑02518‑438499656
     [Google Scholar]
  133. SarievaK. KagermeierT. KhakipoorS. AtayE. YentürZ. BeckerK. MayerS. Human brain organoid model of maternal immune activation identifies radial glia cells as selectively vulnerable.Mol. Psychiatry202328125077508910.1038/s41380‑023‑01997‑136878967
     [Google Scholar]
  134. CuiK. WangY. ZhuY. TaoT. YinF. GuoY. LiuH. LiF. WangP. ChenY. QinJ. Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model.Microsyst. Nanoeng.2020614910.1038/s41378‑020‑0165‑z34567661
     [Google Scholar]
  135. MengQ. ZhangW. WangX. JiaoC. XuS. LiuC. TangB. ChenC. Human forebrain organoids reveal connections between valproic acid exposure and autism risk.Transl. Psychiatry202212113010.1038/s41398‑022‑01898‑x35351869
     [Google Scholar]
  136. ZangZ. YinH. DuZ. XieR. YangL. CaiY. WangL. ZhangD. LiX. LiuT. GongH. GaoJ. YangH. WarnerM. GustafssonJ.A. XuH. FanX. Valproic acid exposure decreases neurogenic potential of outer radial glia in human brain organoids.Front. Mol. Neurosci.202215102376536523605
     [Google Scholar]
  137. NieL. IrwinC. GeahchanS. SinghK.K. Human pluripotent stem cell (hPSC)-derived models for autism spectrum disorder drug discovery.Expert Opin. Drug Discov.202520223325110.1080/17460441.2024.241648439718245
     [Google Scholar]
/content/journals/cn/10.2174/011570159X368403250618054913
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Stem Cell Therapy and Models for Autism Spectrum Disorder: Insights and Research
Curr. Neuropharmacol. 24, 176 (2026); https://doi.org/10.2174/011570159X368403250618054913
/content/journals/cn/10.2174/011570159X368403250618054913
/content/journals/cn/10.2174/011570159X368403250618054913
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  • Article Type:     Review Article
Keyword(s): Autism spectrum disorder; cell-based therapies; cellular therapy; core symptom; stem cell transplantation; stem cells

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