Skip to content
2000
Volume 19, Issue 2
  • ISSN: 2666-1454
  • E-ISSN: 2666-1462

Abstract

L. (Family: Compositae), a medicinal plant that grows as a weed, has a wide distribution in the United States and Canada, Brazil, China, and Malaysia, including hotter regions of India. Traditionally, the herb has been used largely to treat various illnesses. The entire plant, particularly its leaves, roots, fruits, and seeds, has been used in conventional healthcare to treat a variety of conditions, including leukoderma, infections from bacteria and fungi, long-term malaria cases, rheumatism, tuberculosis, allergic rhinitis, sinusitis, urticaria, rheumatoid arthritis, diarrhoea, constipation, and lumbago. In-depth information about the plant's pharmacological and botanical properties is included in this detailed account. The pharmacological properties and their antibacterial, anti-tumor, antitussive, antifungal, anti-inflammatory, antinociceptive, diabetic, antimitotic, antioxidant, antitrypanosomal, CNS depressant, diuretic, contact dermatitis, insecticidal, and herbicidal properties are some of the highlights. Constituents found in all plant components, such as sesquiterpene lactones, glycosides, phenols, and polysterols, account for the majority of the pharmacological actions. Nevertheless, in order to validate conventional knowledge in the context of a sensible phytotherapy, future efforts should focus more on laboratory and investigations as well as clinical trials. Research requires quantification of individual ingredients and assessment of their pharmacological effects in humans due to the herb's multi-activity, especially its anti-tumor and anti-cancer properties, which have garnered a lot of attention.

Loading

Article metrics loading...

/content/journals/cms/10.2174/0126661454314305240826112529
2024-09-02
2026-03-08
Loading full text...

Full text loading...

References

  1. KambojA. SalujaA. Phytopharmacological review of Xanthium strumarium L. (Cocklebur).Int J Green Pharm20104312913910.4103/0973‑8258.69154
    [Google Scholar]
  2. SultanaA. WahabA. PerveenR. HaiderS.S. FarheenR. AnwarA. A brief review on phytochemistry and pharmacological activity of Xanthium strumarium L.Fuuast J Biol201992271276
    [Google Scholar]
  3. AminS. BarkatullahD. KhanH. Pharmacology of Xanthium species. A review.J Phytopharmacol20165312612710.31254/phyto.2016.5308
    [Google Scholar]
  4. BhogaonkarP.Y. AhmadS.A. Pharmacognostic studies on Xanthium strumarium L. a folk Unani medicinal herb.Biosci Discov201231101106
    [Google Scholar]
  5. SnigdhaM. KumarS.S. SharmisthaM. LalitS. TanujaS. An overview on herbal medicines as diuretics with scientific evidence.Scholars J Appl Med Sci201313209214
    [Google Scholar]
  6. FanW. FanL. PengC. Traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics and toxicology of Xanthium strumarium L.: A review.Molecules201924235910.3390/molecules24020359 30669496
    [Google Scholar]
  7. NibretE. YounsM. Krauth-SiegelR.L. WinkM. Biological activities of xanthatin from Xanthium strumarium leaves.Phytother. Res.201125121883189010.1002/ptr.3651 21953905
    [Google Scholar]
  8. HoqueM. RahmanM.M. UddinM.N. A study of central nervous system (CNS) effect of Xanthium strumarium in swiss albino mice.IJSTRD202374936939
    [Google Scholar]
  9. FakudzeN. SarbadhikaryP. GeorgeB. AbrahamseH. Ethnomedicinal uses, phytochemistry, and anticancer potentials of african medicinal fruits: A comprehensive review.Pharmaceuticals2023168111710.3390/ph16081117 37631032
    [Google Scholar]
  10. QaderK.O. Al-SaadiS.A. AllamiR.H. Evaluation of antibacterial activity of Xanthium strumarium L. against pathogenic bacteria.Int. J. Health Sci.20226S11377213778
    [Google Scholar]
  11. MasvingweC. MavenyengwaM. Toxicological evaluation of the plant Xanthium strumarium in pigs in Zimbabwe.J. Venom. Anim. Toxins19984211311910.1590/S0104‑79301998000200003
    [Google Scholar]
  12. KozuharovaE. IonkovaI. SpadaroV. Xanthium strumarium-a potential cheap resource of plant substances for medicinal use.Flora Mediterr.20192993102
    [Google Scholar]
  13. BarkK.M. HeoE.P. HanK.D. Evaluation of the phototoxic potential of plants used in oriental medicine.J. Ethnopharmacol.20101271111810.1016/j.jep.2009.09.058 19818392
    [Google Scholar]
  14. DharmanandaS. Safety issues affecting chinese herbs: The case of ginseng. Institute for Traditional Medicine, Portland, OR 2010; 1.Available from: www.itmonline.org/arts/ginseng.htm
  15. Ginesta-PerisE. Garcia-BreijoF.J. Primo-YúferaE. Antimicrobial activity of xanthatin from Xanthium spinosum L.Lett. Appl. Microbiol.199418420620810.1111/j.1472‑765X.1994.tb00848.x 7765395
    [Google Scholar]
  16. KanthalLK PattanayakS RoyS Phytochemical study and antioxidant activity of methanolic extract of Xanthium strumarium L.2022558284
    [Google Scholar]
  17. HanT. LiH. ZhangQ. ZhengH. QinL. New thiazinediones and other components from Xanthium strumarium.Chem. Nat. Compd.200642556757010.1007/s10600‑006‑0215‑2
    [Google Scholar]
  18. TongC ChenRH LiuDC ZengDS LiuH Chemical constituents from the fruits of Xanthium strumarium and their antitumor effects.Nat Prod Commun20201581934578X209455410.1177/1934578X20945541
    [Google Scholar]
  19. DaiY.H. CuiZ. LiJ.L. A new thiazinedione from Xanthium strumarium.J. Shenyang Pharm. Univ.20072412786787
    [Google Scholar]
  20. YinR.H. BaiX. FengT. DongZ.J. LiZ.H. LiuJ.K. Two new compounds from Xanthium strumarium.J. Asian Nat. Prod. Res.201618435435910.1080/10286020.2015.1099525 26629595
    [Google Scholar]
  21. HuangH. YuJ.G. SunL. Study on the chemical constituents of Chinese medicine Xanthium strumarium.Zhongguo Zhongyao Zazhi200530810271029
    [Google Scholar]
  22. ParveenZ. MazharS. SiddiqueS. ManzoorA. AliZ. Chemical composition and antifungal activity of essential oil from Xanthium strumarium L. leaves.Indian J. Pharm. Sci.201779231632110.4172/pharmaceutical‑sciences.1000232
    [Google Scholar]
  23. FerrerJP ZampiniIC CuelloAS Cytotoxic compounds from aerial organs of Xanthium strumarium.Nat Prod Commun20161131934578X160110010.1177/1934578X1601100313 27169184
    [Google Scholar]
  24. FerrerJ.P. Search of new antimitotics compounds from the Cuban flora.Bol. Latinoam. Caribe Plantas Med. Aromat.20111017582
    [Google Scholar]
  25. MahmoudA. Xanthanolides and xanthane epoxide derivatives from Xanthium strumarium.Planta Med.199864872472710.1055/s‑2006‑957566 17253317
    [Google Scholar]
  26. HabibiZ. LalehA. MasoudiS. RustaiyanA. Composition of the essential oil of Xanthium brasilicum Vellozo from Iran.J. Essent. Oil Res.2004161313210.1080/10412905.2004.9698644
    [Google Scholar]
  27. AgataI. GotoS. HatanoT. NishibeS. OkudaT. 1,3,5-Tri-O-caffeoylquinic acid from Xanthium strumarium.Phytochemistry199333250850910.1016/0031‑9422(93)85551‑2
    [Google Scholar]
  28. HwangS. WangZ. YoonH. LimS. Xanthium strumarium as an inhibitor of α-glucosidase, protein tyrosine phosphatase 1β, protein glycation and ABTS+ for diabetic and its complication.Molecules2016219124110.3390/molecules21091241 27649132
    [Google Scholar]
  29. RodriguezE. TowersG.H.N. MitchellJ.C. Biological activities of sesquiterpene lactones.Phytochemistry197615111573158010.1016/S0031‑9422(00)97430‑2
    [Google Scholar]
  30. PandeyB.P. A text book of botany. Ram Nagar, Delhi, India. S.Chand and company Ltd., p 271 Pandey, D. P. and Rather, M. A. (2012). Isolation and identification of phytochemicals from Xanthium strumarium.Int. J. Chemtech Res.200141266271
    [Google Scholar]
  31. JafriS.M.H. The flora of Karachi. Karachi, Pakistan. Nizamsons, p 339 Jawad, A. I. M., Mahmoud, M. J. and Al-Naib, A. (1988). Antimicrobial activity of Xanthium strumarium.Fitoterapia1966LIX3220221
    [Google Scholar]
  32. QuattrocchiU. CRC world dictionary of medicinal and poisonous plants: Common names, scientific names, eponyms, synonyms, and etymology.CRC press2012
    [Google Scholar]
  33. ZhengL. ChenF. LiY. LiC. Identification of a unique germacrene a oxidase from Xanthium strumarium.Phyton202291598999810.32604/phyton.2022.019219
    [Google Scholar]
  34. MalekzadehR. ArjmandM. AkbariZ. SadeghiS. Haji HosseiniR. The effect of Xanthium strumarium root extracts on growth inhibition of epithelial ovarian cancer SK-OV-3 cell line: A metabolomics-based study.Jundishapur J. Nat. Pharm. Prod.2023182e13503810.5812/jjnpp‑135038
    [Google Scholar]
  35. MalekzadehR. ArjmandM. Haji HosseiniR. VaziriA. ZamaniZ. Evaluation of the anticancer effect of Xanthium Strumarium root extract on human epithelial ovarian cancer cells using 1H NMR-based metabolomics.J Sci Islam Repub Iran2020313205212
    [Google Scholar]
  36. KhanY. ShahS. UllahS. Ethnomedicinal, pharmacological and phytochemical evaluation of Xanthium strumarium L.Int. J. Sci. Eng. Res.202011587595
    [Google Scholar]
  37. MandalS.C. BoominathanR. DeviB.P. PandaS. Studies on anti-tussive activity of Xanthium Strumarium L. extract.Acta Hortic.2005678149152
    [Google Scholar]
  38. DevkotaA. DasR.K. Antifungal activities and phytochemical screening of Xanthium strumarium.Bio Bulletin201621121127
    [Google Scholar]
  39. ParkS.M. JungH.J. HanS.H. Antifungal activity of extract from Xmthitim strumarium L. Against plant pathogenous fungi.J. Life Sci.200515569269510.5352/JLS.2005.15.5.692
    [Google Scholar]
  40. KupieckiF.P. OgzewallaC.D. SchellF.M. Isolation and characterization of a hypoglycemic agent from Xanthium strumarium.J. Pharm. Sci.19746371166116710.1002/jps.2600630736 4852580
    [Google Scholar]
  41. HsuF.L. ChenY.C. ChengJ.T. Caffeic acid as active principle from the fruit of Xanthium strumarium to lower plasma glucose in diabetic rats.Planta Med.200066322823010.1055/s‑2000‑8561 10821047
    [Google Scholar]
  42. ZhangL. TaoL. RuanJ. Xanthatin induces G2/M cell cycle arrest and apoptosis in human gastric carcinoma MKN-45 cells.Planta Med.201278989089510.1055/s‑0031‑1298481 22532019
    [Google Scholar]
  43. Francisco FernandezM. CharfiC. Piloto-FerrerJ. Lidia GonzálezM. LamyS. AnnabiB. Targeting ovarian cancer cell cytotoxic drug resistance phenotype with Xanthium strumarium L. extract.Evid. Based Complement. Alternat. Med.2019201911310.1155/2019/6073019 31827554
    [Google Scholar]
  44. MandalS.C. DharaA.K. Ashok KumarC.K. MaitiB.C. Neuropharmacological activity of Xanthium strumarium Linn. extract.J. Herbs Spices Med. Plants200181697710.1300/J044v08n01_09
    [Google Scholar]
  45. ChandelS. BagaiU. VashishatN. Antiplasmodial activity of Xanthium strumarium against Plasmodium berghei-infected BALB/c mice.Parasitol. Res.201211031179118310.1007/s00436‑011‑2611‑1 21847597
    [Google Scholar]
  46. AttemeneS.D.D. BeourouS. TuoK. Antiplasmodial activity of two medicinal plants against clinical isolates of Plasmodium falciparum and Plasmodium berghei infected mice.J. Parasit. Dis.2018421687610.1007/s12639‑017‑0966‑7 29491562
    [Google Scholar]
  47. DraL.J.N. DraM.D.C. ReinaldoH.R. GastonG.S. JostL.C.F. Effectodiureticodel Xanthium strumarium.Rev. Cuba. Plantas Med.199912225
    [Google Scholar]
  48. HossenM.J. KimM.Y. ChoJ.Y. MAPK/AP-1-targeted anti-inflammatory activities of Xanthium strumarium.Am. J. Chin. Med.20164461111112510.1142/S0192415X16500622 27627914
    [Google Scholar]
  49. AdwasA.A. ElsayedA. AzabA.E. QuwaydirF.A. Oxidative stress and antioxidant mechanisms in human body.J Appl Biotechnol Bioeng2019614347
    [Google Scholar]
  50. JoanofarcJ. SangeetaJ. JayakumariS. KumarS.S. GopinadhB. SamS. Antipyretic and diuretic activity of Ammania baccifera.Nat. Prod. Sci.200393180182
    [Google Scholar]
  51. RoyB. AminM.R. JalalS. KwonY.J. SuhS.J. Evaluation of common cocklebur Xanthium strumarium leaf extract as post‐harvest grain protectant of black gram against pulse beetle Callosobruchus chinensis (Coleoptera: B ruchidae) and isolation of crude compound.Entomol. Res.201444625426110.1111/1748‑5967.12076
    [Google Scholar]
  52. PetroskiR.J. StanleyD.W. Natural compounds for pest and weed control.J. Agric. Food Chem.200957188171817910.1021/jf803828w 19719128
    [Google Scholar]
  53. Sánchez-LamarA. Piloto-FerrerJ. FioreM. Xanthium strumarium extract inhibits mammalian cell proliferation through mitotic spindle disruption mediated by xanthatin.J. Ethnopharmacol.201619478178810.1016/j.jep.2016.11.006 27840259
    [Google Scholar]
  54. DuelliP. ObristM.K. Regional biodiversity in an agricultural landscape: The contribution of seminatural habitat islands.Basic Appl. Ecol.20034212913810.1078/1439‑1791‑00140
    [Google Scholar]
  55. Al-MekhlafiF.A. AbutahaN. MashalyA.M.A. NasrF.A. IbrahimK.E. WadaanM.A. Biological activity of Xanthium strumarium seed extracts on different cancer cell lines and Aedes caspius, Culex pipiens (Diptera: Culicidae).Saudi J. Biol. Sci.201724481782110.1016/j.sjbs.2016.07.003 28490952
    [Google Scholar]
  56. KhampariaS. JaspalD.K. Evaluation of decoloration potential of Xanthium Strumarium seed hull for adsorption of Direct red 81 in aqueous solution.Environ. Dev. Sustain.20171951933195110.1007/s10668‑016‑9836‑1
    [Google Scholar]
  57. StuartB.P. ColeR.J. GosserH.S. Cocklebur (Xanthium strumarium, L. var. strumarium) intoxication in swine: Review and redefinition of the toxic principle.Vet. Pathol.198118336838310.1177/030098588101800310 7257080
    [Google Scholar]
  58. BothaC.J. LessingD. RösemannM. van WilpeE. WilliamsJ.H. Analytical confirmation of Xanthium strumarium poisoning in cattle.J. Vet. Diagn. Invest.201426564064510.1177/1040638714542867 25012081
    [Google Scholar]
  59. WitteS.T. OsweilerG.D. StahrH.M. MobleyG. Cocklebur toxicosis in cattle associated with the consumption of mature Xanthium strumarium.J. Vet. Diagn. Invest.19902426326710.1177/104063879000200402 2095279
    [Google Scholar]
  60. KremerR.J. Management of weed seed banks with microorganisms.Ecol. Appl.199331425210.2307/1941791 27759226
    [Google Scholar]
  61. SaeedA. HussainA. KhanM.I. The influence of environmental factors on seed germination of Xanthium strumarium L.: Implications for management.PLoS One20201510e024160110.1371/journal.pone.0241601 33125445
    [Google Scholar]
  62. Microbiological safety evaluations and recommendations on sprouted seeds.Int. J. Food Microbiol.199952312315310.1016/S0168‑1605(99)00135‑X 10733245
    [Google Scholar]
  63. EvansF. SchmidtR. Plants and plant products that induce contact dermatitis.Planta Med.198038428931610.1055/s‑2008‑1074883 6988852
    [Google Scholar]
  64. XueL.M. ZhangQ.Y. HanP. Hepatotoxic constituents and toxicological mechanism of Xanthium strumarium L. fruits.J. Ethnopharmacol.2014152227228210.1016/j.jep.2013.12.024 24447814
    [Google Scholar]
  65. IqbalM.F. FengY.L. FengW.W. LiuM.C. LuX.R. Ecological impacts of the invasive plant Xanthium strumarium and the impacts of three aboveground herbivores on the invader.Ecol. Indic.202113110814010.1016/j.ecolind.2021.108140
    [Google Scholar]
  66. IqbalM.F. LiuM.C. IramA. FengY.L. Effects of the invasive plant Xanthium strumarium on diversity of native plant species: A competitive analysis approach in North and Northeast China.PLoS One20201511e022847610.1371/journal.pone.0228476 33211690
    [Google Scholar]
  67. HanT. LiH.L. ZhangQ.Y. Bioactivity-guided fractionation for anti-inflammatory and analgesic properties and constituents of Xanthium strumarium L.Phytomedicine2007141282582910.1016/j.phymed.2007.01.010 17350237
    [Google Scholar]
  68. TripathiR.N. DubeyN.K. DixitS.N. Fungitoxicity of pollen grains with special reference to Xanthium strumarium (Compositae).Grana1985241616310.1080/00173138509427424
    [Google Scholar]
  69. McCloskeyJ.W. Analysis of variance in sports injury research.Am. J. Sports Med.198816Suppl. 1S-63S-6410.1177/03635465880160S115 3414889
    [Google Scholar]
  70. XuM. FralickD. ZhengJ.Z. WangB. TuX.M. FengC. The differences and similarities between two-sample t-test and paired t-test.Shanghai Jingshen Yixue2017293184188 28904516
    [Google Scholar]
  71. EdlerL. ThielmannH.W. Analysis of colony‐forming ability of human fibroblast strains by linear regression.Biom. J.198729780782410.1002/bimj.4710290710
    [Google Scholar]
  72. AkçayA. The calculation of LD50 using probit analysis.FASEB J.201327S112171228
    [Google Scholar]
  73. IngawaleA.S. SadiqM.B. NguyenL.T. NganT.B. Optimization of extraction conditions and assessment of antioxidant, α-glucosidase inhibitory and antimicrobial activities of Xanthium strumarium L. fruits.Biocatal. Agric. Biotechnol.201814404710.1016/j.bcab.2018.02.004
    [Google Scholar]
  74. AranjaniJ.M. RaoC.M. ManuelA. RaoJ.V. UdupaN. HebbarK. Acute and subacute toxicity of chloroform and hexaneextracts of root of Xanthium strumarium.Comp. Clin. Pathol.20122161223123010.1007/s00580‑011‑1269‑5
    [Google Scholar]
  75. HongS.H. OhM.J. LeeE.J. Processed Xanthii fructus increases cell viability of mast cell line, RBL-2H3.Adv Tradit Med2004416064
    [Google Scholar]
  76. GhahariS. AlinezhadH. NematzadehG.A. TajbakhshM. BaharfarR. Biochemical composition, antioxidant and biological activities of the essential oil and fruit extract of Xanthium strumarium Linn. from Northern Iran.J. Agric. Sci. Technol.201719716031616
    [Google Scholar]
  77. Piloto FerrerJ. CozziR. CornettaT. Xanthium strumarium L. extracts produce DNA damage mediated by cytotoxicity in in vitro assays but does not induce micronucleus in mice.BioMed Res. Int.201420141810.1155/2014/575197 25025061
    [Google Scholar]
/content/journals/cms/10.2174/0126661454314305240826112529
Loading
/content/journals/cms/10.2174/0126661454314305240826112529
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test