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2000
Volume 19, Issue 2
  • ISSN: 2666-1454
  • E-ISSN: 2666-1462

Abstract

Introduction

Breast cancer is one of the most prevalent cancers affecting the female population worldwide. It is a highly heterogeneous disease mainly classified into three subtypes based on the status of the molecular markers for the hormones (estrogen and progesterone) and epidermal growth factor (HER-2) receptors. Hormone receptor positive breast cancer shows a good prognosis, while tumors that do not show any of these receptors (triple negative breast cancer) are highly invasive. Despite all the conventional therapies for the treatment of breast cancer, it remains the leading cause of cancer deaths of women worldwide. Chemical grafting of nanoparticles (NPs) with polymers and surface modifiers as a targeted ligand can become an alternative for active targeting. Hence, these polymeric NPs can control drug release with pH-responsive stimuli, and the high selectivity of these NPs allows them to accumulate more inside the cancer cells that overexpress these receptors, leaving normal cells unaffected.

Methods

Formulation incorporates various polymers, solvents drug, and stabilizing agents in the aqueous phase. Various techniques discussed in this review are employed for synthesis, resulting in a dry NP formulation.

Results

In this context, we shall discuss the development of NPs against distinct forms of cancer malignancies. From here, we know that polymeric NPs can produce a system with good characteristics, effectiveness, and active targeting of different cancer cells.

Conclusion

This system is a striking candidate for the targeted drug delivery for cancer therapy, anticipating that NPs could be further developed for various breast cancer therapy applications.

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References

  1. SiegelR.L. MillerK.D. JemalA. Cancer statistics, 2016.CA Cancer J. Clin.201666173010.3322/caac.21332 26742998
     [Google Scholar]
  2. CattyN.J. FoggittA. HamiltonC.R. RoyleG.T. TaylorI. Patterns of clinical metastasis in breast cancer: An analysis of 100 patients.Eur. J. Surg. Oncol.1995216607608
     [Google Scholar]
  3. GrobmyerS.R. ZhouG. GutweinL.G. IwakumaN. SharmaP. HochwaldS.N. Nanoparticle delivery for metastatic breast cancer.Nanomedicine20128Suppl. 1S21S3010.1016/j.nano.2012.05.011 22640908
     [Google Scholar]
  4. ErolesP. BoschA. Alejandro Pérez-FidalgoJ. LluchA. Molecular biology in breast cancer: Intrinsic subtypes and signaling pathways.Cancer Treat. Rev.201238669870710.1016/j.ctrv.2011.11.005 22178455
     [Google Scholar]
  5. DaviesE. HiscoxS. New therapeutic approaches in breast cancer.Maturitas201168212112810.1016/j.maturitas.2010.10.012 21144683
     [Google Scholar]
  6. Fraguas-SánchezA.I. Torres-SuárezA.I. Development of innovative formulations for breast cancer chemotherapy. Cancers.MDPI AG2020Vol. 1213
     [Google Scholar]
  7. SinghS.K. SinghS. WlillardJ. SinghR. Drug delivery approaches for breast cancer.Int. J. Nanomedicine2017126205621810.2147/IJN.S140325
     [Google Scholar]
  8. BanghamA.D. Liposomes: the Babraham connection.Chem. Phys. Lipids1993641-327528510.1016/0009‑3084(93)90071‑A 8242839
     [Google Scholar]
  9. JaraiB.M. KoleweE.L. StillmanZ.S. RamanN. FromenC.A. Polymeric Nanoparticles.In: Nanoparticles for Biomedical Applications.30324
     [Google Scholar]
  10. DadwalM. Polymeric nanoparticles as promising novel carriers for drug delivery : An overview.J. Adv. Pharm. Educ. Res.2014412030
     [Google Scholar]
  11. SanitàG. CarreseB. LambertiA. Nanoparticle surface functionalization: How to improve biocompatibility and cellular internalization.Front. Mol. Biosci.20207November58701210.3389/fmolb.2020.587012 33324678
     [Google Scholar]
  12. HerdianaY. WathoniN. ShamsuddinS. JoniI.M. MuchtaridiM. Chitosan-based nanoparticles of targeted drug delivery system in breast cancer treatment.Polymers202113111717
     [Google Scholar]
  13. AzandaryaniA.H. KashanianS. ShahlaeiM. DerakhshandehK. MotieiM. MoradiS. A comprehensive physicochemical, in vitro and molecular characterization of letrozole incorporated chitosan-lipid nanocomplex.Pharm. Res.20193646210.1007/s11095‑019‑2597‑4 30850895
     [Google Scholar]
  14. Salahpour AnarjanF. Active targeting drug delivery nanocarriers: Ligands.Nano-Struct Nano-Objects20191910037010.1016/j.nanoso.2019.100370
     [Google Scholar]
  15. LorscheiderM. GaudinA. NakhléJ. VeimanK.L. RichardJ. ChassaingC. Challenges and opportunities in the delivery of cancer therapeutics: Update on recent progress.Ther. Deliv.2021121557610.4155/tde‑2020‑0079 33307811
     [Google Scholar]
  16. ParesishviliT. KakabadzeZ. Challenges and opportunities associated with drug delivery for the treatment of solid tumors.Oncol. Rev.202317August1057710.3389/or.2023.10577 37711860
     [Google Scholar]
  17. HafeezM.N. CeliaC. Challenges towards targeted drug delivery in cancer nanomedicines.Processes2021991527
     [Google Scholar]
  18. Gonzalez-ValdiviesoJ. GirottiA. SchneiderJ. AriasF.J. Advanced nanomedicine and cancer: Challenges and opportunities in clinical translation.Int. J. Pharm.2021599March12043810.1016/j.ijpharm.2021.120438 33662472
     [Google Scholar]
  19. RosenblumD. JoshiN. TaoW. KarpJ.M. PeerD. Progress and challenges towards targeted delivery of cancer therapeutics.Nat. Commun.201891141010.1038/s41467‑018‑03705‑y 29650952
     [Google Scholar]
  20. WilliamsR.M. ShahJ. NgB.D. Mesoscale nanoparticles selectively target the renal proximal tubule epithelium.Nano Lett.20151542358236410.1021/nl504610d 25811353
     [Google Scholar]
  21. ClinicalTrials.gov. Carboplatin and nab-paclitaxel with or without vorinostat in treating women with newly diagnosed operable breast cancer; NCT00616967.Available From: https://clinicaltrials.gov/study/NCT00616967
  22. GrewalI.K. SinghS. AroraS. SharmaN. Polymeric nanoparticles for breast cancer therapy: A comprehensive review.Biointerface Res. Appl. Chem.20211141115111171
     [Google Scholar]
  23. MoreiraR. GranjaA. PinheiroM. ReisS. Nanomedicine interventions in clinical trials for the treatment of metastatic breast cancer.Appl. Sci.20211141624
     [Google Scholar]
  24. BahreyniA. MohamudY. LuoH. Emerging nanomedicines for effective breast cancer immunotherapy.J. Nanobiotechnology202018118010.1186/s12951‑020‑00741‑z
     [Google Scholar]
  25. Hernandez-AyaL.F. GaoF. GoedegebuureP.S. MaC.X. AdemuyiwaF.O. ParkH. A randomized phase II study of nab-paclitaxel + durvalumab + neoantigen vaccine versus nab-paclitaxel + durvalumab in metastatic triple-negative breast cancer (mTNBC).J. Clin. Oncol.20193715_supplTPS1114TPS4
     [Google Scholar]
  26. HerdianaY. WathoniN. ShamsuddinS. MuchtaridiM. Scale-up polymeric-based nanoparticles drug delivery systems: Development and challenges.OpenNano20227May10004810.1016/j.onano.2022.100048
     [Google Scholar]
  27. TangX. LocW.S. DongC. MattersG.L. ButlerP.J. KesterM. The use of nanoparticulates to treat breast cancer. Nanomedicine.Future Medicine Ltd.2017Vol. 1223672388
     [Google Scholar]
  28. ChandnaP. KhandareJ.J. BerE. Rodriguez-RodriguezL. MinkoT. Multifunctional tumor-targeted polymer-peptide-drug delivery system for treatment of primary and metastatic cancers.Pharm. Res.201027112296230610.1007/s11095‑010‑0235‑2 20700631
     [Google Scholar]
  29. VivekR ThangamR NipunBabuV Multifunctional HER2-antibody conjugated polymeric nanocarrier-based drug delivery system for multi-drug-resistant breast cancer therapy.ACS Appl. Mater. Interfaces2014696469648010.1021/am406012g 24780315
     [Google Scholar]
  30. DuJ.Z. DuX.J. MaoC.Q. WangJ. Tailor-made dual pH-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery.J. Am. Chem. Soc.201113344175601756310.1021/ja207150n 21985458
     [Google Scholar]
  31. ShamayY. AdarL. AshkenasyG. DavidA. Light induced drug delivery into cancer cells.Biomaterials20113251377138610.1016/j.biomaterials.2010.10.029 21074848
     [Google Scholar]
  32. FitzpatrickS.D. FitzpatrickL.E. ThakurA. MazumderM.A.J. SheardownH. Temperature-sensitive polymers for drug delivery.Expert Rev. Med. Devices20129433935110.1586/erd.12.24 22905838
     [Google Scholar]
  33. LensenD. GelderblomE.C. VriezemaD.M. Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release.Soft Matter20117115417542210.1039/c1sm05324h
     [Google Scholar]
  34. LiechtyW.B. KryscioD.R. SlaughterB.V. PeppasN.A. Polymers for drug delivery systems.Annu. Rev. Chem. Biomol. Eng.201011149173 22432577
     [Google Scholar]
  35. VermaR.K. MishraB. GargS. Osmotically controlled oral drug delivery.Drug Dev. Ind. Pharm.200026769570810.1081/DDC‑100101287 10872087
     [Google Scholar]
  36. AdairJ.H. ParetteM.P. AltınoğluE.İ. KesterM. Nanoparticulate alternatives for drug delivery.ACS Nano2010494967497010.1021/nn102324e 20873786
     [Google Scholar]
  37. GaoM. LongX. DuJ. Enhanced curcumin solubility and antibacterial activity by encapsulation in PLGA oily core nanocapsules.Food Funct.202011144845510.1039/C9FO00901A 31829367
     [Google Scholar]
  38. BechnakL. KhalilC. KurdiR.E. KhnayzerR.S. PatraD. Curcumin encapsulated colloidal amphiphilic block co-polymeric nanocapsules: Colloidal nanocapsules enhance photodynamic and anticancer activities of curcumin.Photochem. Photobiol. Sci.20201981088109810.1039/d0pp00032a 32638825
     [Google Scholar]
  39. AvramovićN. MandićB. Savić-RadojevićA. SimićT. Polymeric nanocarriers of drug delivery systems in cancer therapy.Pharmaceutics202012429810.3390/pharmaceutics12040298 32218326
     [Google Scholar]
  40. LawsonM.K. Improvement of therapeutic value of quercetin with chitosan nanoparticle delivery systems and potential applications.Int. J. Mol. Sci.20232443293
     [Google Scholar]
  41. QiL. XuZ. ChenM. In vitro and in vivo suppression of hepatocellular carcinoma growth by chitosan nanoparticles.Eur. J. Cancer200743118419310.1016/j.ejca.2006.08.029 17049839
     [Google Scholar]
  42. BuL. GanL.C. GuoX.Q. Trans-resveratrol loaded chitosan nanoparticles modified with biotin and avidin to target hepatic carcinoma.Int. J. Pharm.20134521-235536210.1016/j.ijpharm.2013.05.007 23685116
     [Google Scholar]
  43. RejinoldN.S. MuthunarayananM. MuthuchelianK. ChennazhiK.P. NairS.V. JayakumarR. Saponin-loaded chitosan nanoparticles and their cytotoxicity to cancer cell lines in vitro.Carbohydr. Polym.201184140741610.1016/j.carbpol.2010.11.056
     [Google Scholar]
  44. LiS.Y. SunR. WangH.X. Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome resistance by breast cancer stem cells.J. Control. Release201520571410.1016/j.jconrel.2014.11.011 25445694
     [Google Scholar]
  45. KhannaV. KalscheuerS. KirtaneA. ZhangW. PanyamJ. Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer.Future Drug Discov.201911FDD810.4155/fdd‑2019‑0005
     [Google Scholar]
  46. SwaminathanS.K. RogerE. TotiU. NiuL. OhlfestJ.R. PanyamJ. CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer.J. Control. Release2013171328028710.1016/j.jconrel.2013.07.014 23871962
     [Google Scholar]
  47. HosseiniS.M. MohammadnejadJ. SalamatS. Beiram ZadehZ. TanhaeiM. RamakrishnaS. Theranostic polymeric nanoparticles as a new approach in cancer therapy and diagnosis: A review.Mater. Today Chem.20232910140010.1016/j.mtchem.2023.101400
     [Google Scholar]
  48. MaZ. MoultonB. Recent advances of discrete coordination complexes and coordination polymers in drug delivery.Coord. Chem. Rev.201125515-161623164110.1016/j.ccr.2011.01.031
     [Google Scholar]
  49. GibsonM. Pharmaceutical preformulation and formulation : A practical guide from candidate drug selection to commercial dosage form.Boca RatonCRC Press2008
     [Google Scholar]
  50. HanE.J. ChungA.H. OhI.J. Analysis of residual solvents in poly(lactide-co-glycolide) nanoparticles.J. Pharm. Investig.201242525125610.1007/s40005‑012‑0034‑3
     [Google Scholar]
  51. LiuY. ShenJ. ShiJ. GuX. ChenH. WangX. Functional polymeric core–shell hybrid nanoparticles overcome intestinal barriers and inhibit breast cancer metastasis.Chem. Eng. J.202242713174210.1016/j.cej.2021.131742
     [Google Scholar]
  52. ElbazN.M. ZikoL. SiamR. MamdouhW. Core-shell silver/polymeric nanoparticles-based combinatorial therapy against breast cancer in-vitro.Sci. Rep.2016613072910.1038/srep30729 27491622
     [Google Scholar]
  53. ChouhanR. BajpaiA.K. Real time in vitro studies of doxorubicin release from PHEMA nanoparticles.J. Nanobiotechnology200971510.1186/1477‑3155‑7‑5 19843333
     [Google Scholar]
  54. NavyaP.N. KaphleA. SrinivasS.P. BhargavaS.K. RotelloV.M. DaimaH.K. Current trends and challenges in cancer management and therapy using designer nanomaterials.Nano Converg.2019612310.1186/s40580‑019‑0193‑2 31304563
     [Google Scholar]
  55. PerumalS. Polymer nanoparticles: Synthesis and applications.Polymers20221424544910.3390/polym14245449 36559816
     [Google Scholar]
  56. ReisCP NeufeldRJ RibeiroAJ VeigaF Nanoencapsulation I: Methods for preparation of drug-loaded polymeric nanoparticles.Nanomedicine.20062182110.1016/j.nano.2005.12.003 17292111
     [Google Scholar]
  57. WeberC. CoesterC. KreuterJ. LangerK. Desolvation process and surface characterisation of protein nanoparticles.Int. J. Pharm.2000194191102
     [Google Scholar]
  58. ElzoghbyA.O. SamyW.M. ElgindyN.A. Albumin-based nanoparticles as potential controlled release drug delivery systems.J. Control. Release2012157216818210.1016/j.jconrel.2011.07.031 21839127
     [Google Scholar]
  59. LiuM. ZhouZ. WangX. Formation of poly(l,d-lactide) spheres with controlled size by direct dialysis.Polymer200748195767577910.1016/j.polymer.2007.07.053
     [Google Scholar]
  60. ChoiS.W. KimJ.H. Design of surface-modified poly(d,l-lactide-co-glycolide) nanoparticles for targeted drug delivery to bone.J. Control. Release20071221243010.1016/j.jconrel.2007.06.003 17628158
     [Google Scholar]
  61. RaoJ.P. GeckelerK.E. Polymer nanoparticles: Preparation techniques and size-control parameters.In: Progress in Polymer Science. Elsevier Ltd201136887913
     [Google Scholar]
  62. FanW. YanW. XuZ. NiH. Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique.Colloids Surf. B Biointerfaces2012901212710.1016/j.colsurfb.2011.09.042 22014934
     [Google Scholar]
  63. FessiH. PuisieuxF. DevissaguetJ.P. AmmouryN. BenitaS. Nanocapsule formation by interfacial polymer deposition following solvent displacement.Int. J. Pharm.1989551R1R410.1016/0378‑5173(89)90281‑0
     [Google Scholar]
  64. SoppimathK.S. AminabhaviT.M. KulkarniA.R. RudzinskiW.E. Biodegradable polymeric nanoparticles as drug delivery devices.J. Control. Release2001701-212010.1016/S0168‑3659(00)00339‑4
     [Google Scholar]
  65. HoaL.T.M. ChiN.T. NguyenL.H. ChienD.M. Preparation and characterisation of nanoparticles containing ketoprofen and acrylic polymers prepared by emulsion solvent evaporation method.J. Exp. Nanosci.20127218919710.1080/17458080.2010.515247
     [Google Scholar]
  66. JaiswalJ. Kumar GuptaS. KreuterJ. Preparation of biodegradable cyclosporine nanoparticles by high-pressure emulsification-solvent evaporation process.J. Control. Release200496116917810.1016/j.jconrel.2004.01.017 15063039
     [Google Scholar]
  67. Pinto ReisC. NeufeldR.J. RibeiroA.J. VeigaF. NanoencapsulationI. Methods for preparation of drug-loaded polymeric nanoparticles.Nanomed20062182110.1016/j.nano.2005.12.003
     [Google Scholar]
  68. VarshosazJ. HassanzadehF. MahmoudzadehM. SadeghiA. Preparation of cefuroxime axetil nanoparticles by rapid expansion of supercritical fluid technology.Powder Technol.200918919710210.1016/j.powtec.2008.06.009
     [Google Scholar]
  69. Singh SekhonB. Supercritical fluid technology: An overview of pharmaceutical applications.Int. J. Pharm. Tech. Res.200621810826
     [Google Scholar]
  70. VauthierC. BouchemalK. Methods for the preparation and manufacture of polymeric nanoparticles.Pharm. Res.20092651025105810.1007/s11095‑008‑9800‑3
     [Google Scholar]
  71. GovenderT. StolnikS. GarnettM.C. IllumL. DavisS.S. PLGA nanoparticles prepared by nanoprecipitation: Drug loading and release studies of a water soluble drug.J. Control. Release199957217118510.1016/S0168‑3659(98)00116‑3 9971898
     [Google Scholar]
  72. MurakamiH. KobayashiM. TakeuchiH. KawashimaY. Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method.Int. J. Pharm.1999187214315210.1016/s0378‑5173(99)00187‑8
     [Google Scholar]
  73. GallardoM. Study of the mechanisms of formation of nanoparticles and nanocapsules of polyisobutyl-2-cyanoacrylate.Int. J. Pharm.19931001-3556410.1016/0378‑5173(93)90075‑Q
     [Google Scholar]
  74. DuclairoirC. NakacheE. MarchaisH. OrecchioniA.M. Formation of gliadin nanoparticles: Influence of the solubility parameter of the protein solvent.Colloid Polym. Sci.199827632132710.1007/s003960050246
     [Google Scholar]
  75. AboubakarM. PuisieuxF. CouvreurP. DeymeM. VauthierC. Study of the mechanism of insulin encapsulation in poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization.J. Biomed. Mater. Res.199947456857610.1002/(sici)1097‑4636(19991215)47:4568:aid‑jbm143.0.co;2‑x
     [Google Scholar]
  76. BertholonI. LesieurS. LabarreD. BesnardM. VauthierC. Characterization of dextran-poly(isobutylcyanoacrylate) copolymers obtained by redox radical and anionic emulsion polymerization.Macromolecules200639103559356710.1021/ma060338z
     [Google Scholar]
  77. LegrandP. LesieurS. BochotA. Influence of polymer behaviour in organic solution on the production of polylactide nanoparticles by nanoprecipitation.Int. J. Pharm.20073441-2334310.1016/j.ijpharm.2007.05.054 17616282
     [Google Scholar]
  78. BertholonI. VauthierC. LabarreD. Complement activation by core-shell poly(isobutylcyanoacrylate)-polysaccharide nanoparticles: Influences of surface morphology, length, and type of polysaccharide.Pharm. Res.20062361313132310.1007/s11095‑006‑0069‑0 16715369
     [Google Scholar]
  79. Pinto-alphandaryH. CouvreurP. A new method to isolate polyalkylcyanoacrylate nanoparticle preparations.J. Drug Target.19953216716910.3109/10611869509059216
     [Google Scholar]
  80. ChielliniE. CovolanV.L. OrsiniL.M. SolaroR. Polymeric nanoparticles based on polylactide and related copolymers.Macromol. Symp.200319734535410.1002/masy.200350730
     [Google Scholar]
  81. BouchemalK. PonchelG. MazzaferroS. A new approach to determine loading efficiency of Leu-enkephalin in poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan.J. Drug Deliv. Sci. Technol.200818639239710.1016/S1773‑2247(08)50077‑3
     [Google Scholar]
  82. HillaireauH. LedoanT. ChacunH. JaninJ. CouvreurP. Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers.Int. J. Pharm.2007331214815210.1016/j.ijpharm.2006.10.031 17150318
     [Google Scholar]
  83. Oligonucleotide radiolabelling particle size and zeta potential measurements.
     [Google Scholar]
  84. LimayemI. CharcossetC. FessiH. Purification of nanoparticle suspensions by a concentration/diafiltration process.Separ. Purif. Tech.20043811910.1016/j.seppur.2003.10.002
     [Google Scholar]
  85. MadaeniS.S. FaneA.G. Microfiltration of very dilute colloidal mixtures.J. Membr. Sci.1996113230131210.1016/0376‑7388(95)00129‑8
     [Google Scholar]
  86. TishchenkoG. HilkeR. AlbrechtW. SchauerJ. LuetzowK. PientkaZ. Ultrafiltration and microfiltration membranes in latex purification by diafiltration with suction.Sep. Purif. Technol2003301576810.1016/S1383‑5866(02)00120‑X
     [Google Scholar]
  87. BeckP. SchererD. KreutertJ. Separation of drug-loaded nanoparticles from free drug by gel filtration.J. Microencapsul.19907449149610.3109/02652049009040471
     [Google Scholar]
  88. MassonV. MaurinF. FessiH. Influence of sterilization processes on poly(epsilon-caprolactone) nanospheres.Biomaterials1997184327335
     [Google Scholar]
  89. SommerfeldP. SchroederU. SabelB.A. Sterilization of unloaded polybutylcyanoacrylate nanoparticles.Int. J. Pharm.19981641-211311810.1016/S0378‑5173(97)00394‑3
     [Google Scholar]
  90. RollotJ.M. Physicochemical and morphological characterization of polyisobutyl cyanoacrylate nanocapsules.J. Pharm. Sci.1986754361364
     [Google Scholar]
  91. BosG.W. Trullas-JimenoA. JiskootW. CrommelinJ.A. HenninkW.E. Sterilization of poly(dimethylamino) ethyl methacrylate-based gene transfer complexes.Int. J. Pharm.20002111-2798810.1016/s0378‑5173(00)00593‑7
     [Google Scholar]
  92. BoessC. BöglK.W. Influence of radiation treatment on pharmaceuticals-A review: Alkaloids, morphine derivatives, and antibiotics.Drug Dev. Ind. Pharm.199622649552910.3109/03639049609108354
     [Google Scholar]
  93. SintzelM.B. MerkliA. TabatabayC. GurnyR. Influence of irradiation sterilization on polymers used as drug carriers-A review.Drug Dev. Ind. Pharm.199723985787810.3109/03639049709148693
     [Google Scholar]
  94. Memisoglu-BilensoyE. HincalA.A. Sterile, injectable cyclodextrin nanoparticles: Effects of gamma irradiation and autoclaving.Int. J. Pharm.20063111-220320810.1016/j.ijpharm.2005.12.013 16413708
     [Google Scholar]
  95. Ne BriggerI. Armand-LefevreL. ChaminadeP. BesnardM. RigaldieY. LargeteauA. The stenlying effect of high hydrostatic pressure on thermally and hydrolytically labile nanosized carriers.Pharm. Res.200320467468310.1023/a:1023267304096
     [Google Scholar]
  96. LayreA.M. CouvreurP. RichardJ. RequierD. Eddine GhermaniN. GrefR. Freeze-drying of composite core-shell nanoparticles.Drug Dev. Ind. Pharm.200632783984610.1080/03639040600685134 16908421
     [Google Scholar]
  97. AbdelwahedW. DegobertG. StainmesseS. FessiH. Freeze-drying of nanoparticles: Formulation, process and storage considerations.Adv. Drug Deliv. Rev.200658151688171310.1016/j.addr.2006.09.017
     [Google Scholar]
  98. AbdelwahedW. DegobertG. FessiH. Freeze-drying of nanocapsules: Impact of annealing on the drying process.Int. J. Pharm.20063241748210.1016/j.ijpharm.2006.06.047 16904277
     [Google Scholar]
  99. Tewa-TagneP. BriançonS. FessiH. Spray-dried microparticles containing polymeric nanocapsules: Formulation aspects, liquid phase interactions and particles characteristics.Int. J. Pharm.20063251-2637410.1016/j.ijpharm.2006.06.025 16872767
     [Google Scholar]
  100. Mü LlerC.R. BassaniV.L. PohlmannA.R. MichalowskiC.B. PetrovickP.R. GuterresS.S. Preparation and characterization of spray-dried polymeric nanocapsules.Drug Dev. Ind. Pharm.200026334334710.1081/ddc‑100100363
     [Google Scholar]
  101. AdlerM. UngerM. LeeG. Surface composition of spray-dried particles of bovine serum albumin/trehalose/] surfactant.Pharm. Res.200017786387010.1023/A:1007568511399
     [Google Scholar]
  102. BroadheadlJ. The spray drying of pharmaceuticals.Drug Dev. Ind. Pharm.19921811-1211691206
     [Google Scholar]
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Polymeric Nanoparticles: Targeted Delivery in Breast Cancer - A Review
Current Materials Science 19, 190 (2026); https://doi.org/10.2174/0126661454345326241206062935
/content/journals/cms/10.2174/0126661454345326241206062935
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  • Article Type:     Review Article
Keyword(s): active targeting; aqueous phase; Breast cancer; NPS drug delivery; polymeric nanoparticles; polymers; targeted drug delivery

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