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image of Genetic Association Between Sleep Traits and Vertigo Risk: A Two-sample Bidirectional Mendelian Randomization Study

Abstract

Background

Observational studies suggest the potential association between sleep traits and vertigo; however, causal evidence remains limited.

Objective

This study aimed to explore the relationship between genetically predicted sleep traits and vertigo with the Mendelian randomization (MR) method.

Methods

Instrumental variables for sleep traits (snoring, sleep duration, insomnia, daytime sleepiness, daytime napping, and chronotype) were adopted from genome-wide association studies (GWAS) data of European ancestry from UK Biobank. The summary-level datasets of vertigo were retrieved from the GWAS of FinnGen. Inverse-variance weighted (IVW) method was adopted as the main analysis.

Results

IVW analysis revealed a significant association between genetically predicted daytime napping (OR = 1.51, 95% CI =1.08-2.12, P = 0.016) and chronotype (OR = 1.13, 95% CI =1.01-1.26, P = 0.033), both of which were associated with an increased risk of vertigo. However, we did not find evidence for a causal effect of snoring, overall sleep duration, long sleep duration, short sleep duration, insomnia, and excessive daytime sleepiness on vertigo. No reverse causality was detected.

Conclusion

Our findings suggest that abnormal sleep patterns may serve as risk factors for vertigo disorders and offer opportunities for the prevention and management of vertigo disorders.

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2025-07-10
2025-09-14

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Genetic Association Between Sleep Traits and Vertigo Risk: A Two-sample Bidirectional Mendelian Randomization Study
Bentham Science Publishers ; https://doi.org/10.2174/0115665240358943250612115854
/content/journals/cmm/10.2174/0115665240358943250612115854
/content/journals/cmm/10.2174/0115665240358943250612115854
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  • Article Type:     Research Article
Keywords: mendelian randomization ; risk factors ; vertigo ; genetic association ; Sleep traits ; causal relationship

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