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2000
Volume 21, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Introduction

The aim of this study was to evaluate the correlation between ultrasonography, magnetic resonance imaging, and pathology with Fibrolipomatous Hamartoma (FLH) of the peripheral nerve.

Methods

Sixteen patients who underwent surgical treatment for FLH of the peripheral nerve were included in the study. Ultrasound examination and Magnetic Resonance Imaging (MRI) were used to display the detailed anatomical structure of the region well enough to detect FLH. The features presented based on the results of ultrasound examination and magnetic resonance imaging were recorded.

Results

The involved peripheral nerve showed expansive growth in ultrasonography and MRI. The hyperechoic fat tissue and hypoechoic nerve fibers alternated with one another. In ultrasonography and MRI, the peripheral nerve exhibited a lotus-like appearance in the transverse plane, and a cable-like appearance in the longitudinal plane, while there was no blood flow signal in the nerve.

Discussion

The imaging features of FLH, including the characteristic lotus-like and cable-like appearances, align closely with pathological findings, underscoring the diagnostic value of ultrasonography and MRI. These non-invasive techniques facilitate differentiation from other peripheral nerve pathologies, such as carpal tunnel syndrome or hemangioma. Limitations include the retrospective design, small MRI subgroup, and lack of long-term follow-up. Future multicenter studies with larger cohorts are recommended to validate these findings.

Conclusion

Ultrasonography and MRI may be valuable in the diagnosis of FLH of the peripheral nerve.

© 2025 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2025-08-04
2025-09-19

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References

  1. RanjanR. KumarR. JeyaramanM. KumarS. Fibrolipomatous Hamartoma (FLH) of Median Nerve: A Rare Case Report and Review.Indian J. Orthop.202155S1Suppl. 126727210.1007/s43465‑020‑00149‑934113430
     [Google Scholar]
  2. OkechiH. DimostheniA. KerscherS.R. GugelI. BevotA. SchaeferJ.F. SchuhmannM.U. Fibrolipomatous hamartomas of the median nerve in infancy and early childhood—imaging hallmarks, symptomatology, and treatment.Eur. J. Pediatr.2018177456757310.1007/s00431‑018‑3100‑729383435
     [Google Scholar]
  3. WhittleC. SchonstedtV. SchiappacasseG. Fibrolipomatous hamartoma and its ultrasound diagnosis: case series and review of the literature.Ultrasound Q.201430428228610.1097/RUQ.000000000000005125415865
     [Google Scholar]
  4. PaolantonioG. CirilloM. GrussuF. GiancristoforoS. BascettaS. ParapattG.K. RolloM. TomàP. Fibrolipomatous hamartoma of the median nerve: An unusual cause of carpal tunnel syndrome.Clin Case Rep2023113e702210.1002/ccr3.702236418537
     [Google Scholar]
  5. PaolantonioG CirilloM GrussuF Fibrolipomatous hamartoma of the median nerve in a child with carpal tunnel syndrome: imaging findings and literature review.J Ultrasound202326491391810.1007/s40477‑022‑00741‑932082444
     [Google Scholar]
  6. KumariA. SinghS. GargA. PrakashA. SuralS. Tingling hand: magnetic resonance imaging of median nerve pathologies within the carpal tunnel.Pol. J. Radiol.20198448449010.5114/pjr.2019.9035432082444
     [Google Scholar]
  7. GalloneG. Di GennaroG.L. FarrS. Peripheral Nerve Compression Syndromes in Children.J. Hand Surg. Am.202045985786310.1016/j.jhsa.2020.04.02832646712
     [Google Scholar]
  8. NielsenG.P. Lipomatosis of nerve.World Health Organization classification of tumours. Pathology and genetics of tumours of soft tissue and bone. FletcherC.D. UnniK.K. MertensF. LyonIARC Press2002
     [Google Scholar]
  9. KakitsubataY. TheodorouS.J. TheodorouD.J. ShibataM. YugeM. YukiY. HatakeyamaK. YokouchiT. MR imaging of uncommon recurrence of fibrolipomatous hamartoma of the ulnar nerve.Acta Radiol.200344332632812752006
     [Google Scholar]
  10. Mohammed SaeedM.A. DawoodA.A. MahmoodH.M. Lipofibromatous hamartoma of the median nerve with macrodactyly of middle finger.J. Clin. Orthop. Trauma20191061077108110.1016/j.jcot.2019.05.02331708632
     [Google Scholar]
  11. WarrenR.B. VerbovJ.L. AshworthM. Precalcaneal congenital fibrolipomatous hamartoma.Pediatr. Dermatol.2007241747510.1111/j.1525‑1470.2007.00340.x17300657
     [Google Scholar]
  12. MaromE.M. HelmsC.A. Fibrolipomatous hamartoma: pathognomonic on MR imaging.Skeletal Radiol.199928526026410.1007/s00256005051210424331
     [Google Scholar]
  13. GuthikondaM. RengacharyS.S. BalkoM.G. van LoverenH. Lipofibromatous hamartoma of the median nerve: case report with magnetic resonance imaging correlation.Neurosurgery199435112713110.1227/00006123‑199407000‑000197936133
     [Google Scholar]
  14. HsuP.C. ChangK.V. WuW.T. WangJ.C. ÖzçakarL. Effects of ultrasound-guided peritendinous and intrabursal corticosteroid injections on shoulder tendon elasticity: A post hoc analysis of a randomized controlled trial.Arch. Phys. Med. Rehabil.2021102590591310.1016/j.apmr.2020.11.01133338463
     [Google Scholar]
  15. LinC.Y. ChouC.C. ChenL.R. WuW.T. HsuP.C. YangT.H. ChangK.V. Quantitative Analysis of Dynamic Subacromial Ultrasonography: Reliability and Influencing Factors.Front. Bioeng. Biotechnol.20221083050810.3389/fbioe.2022.83050835242751
     [Google Scholar]
  16. DekaJ.B. DekaN.K. ShahM.V. BhatnagarN. NanniA.L. JimenezF. Intraneural hemangioma in Klippel–Trenaunay syndrome: role of musculo-skeletal ultrasound in diagnosis—case report and review of the literature.J. Ultrasound202023343544210.1007/s40477‑020‑00434‑132078146
     [Google Scholar]
  17. PaduaL. CuccagnaC. GiovanniniS. CoraciD. PelosiL. LoretiC. BernabeiR. Hobson-WebbL.D. Carpal tunnel syndrome: updated evidence and new questions.Lancet Neurol.202322325526710.1016/S1474‑4422(22)00432‑X36525982
     [Google Scholar]
  18. EricksonM. LawrenceM. LucadoA. The role of diagnostic ultrasound in the examination of carpal tunnel syndrome: an update and systematic review.J. Hand Ther.202235221522510.1016/j.jht.2021.04.01434261588
     [Google Scholar]
  19. XingG. ShangX. HuoX. HanS. WangY. XuW. Fibrolipomatous hamartoma of the median nerve: A clinical report of one case and review of the literature.Curr. Med. Imaging20231914e23012321300410.2174/157340561966623012311303036694321
     [Google Scholar]
  20. VelickiK. GoldfarbC.A. RobertsS. WallL.B. Outcomes of pediatric and adolescent carpal tunnel release.J. Hand Surg. Am.202146317818610.1016/j.jhsa.2020.09.00933139118
     [Google Scholar]
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Ultrasound and MRI Correlations with Pathological Findings in Fibrolipomatous Hamartoma of Peripheral Nerves
Curr. Med. Imaging 21, E15734056375869 (2025); https://doi.org/10.2174/0115734056375869250728075232
/content/journals/cmir/10.2174/0115734056375869250728075232
/content/journals/cmir/10.2174/0115734056375869250728075232
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  • Article Type:     Research Article
Keyword(s): Cable-like appearances; Fibrolipomatous hamartoma; Magnetic resonance imaging; Neuropathic symptoms; Peripheral nerve; Ultrasonography

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