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Volume 21, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background and Objective

The incidence of Alzheimer’s disease is rising with the increasing elderly population worldwide. While no cure exists, early diagnosis can significantly slow disease progression. Computer-aided diagnostic systems are becoming critical tools for assisting in the early detection of Alzheimer’s disease. In this systematic review, we aim to evaluate recent advancements in computer-aided decision support systems for Alzheimer’s disease diagnosis, focusing on data modalities, machine learning methods, and performance metrics.

Methods

We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies published between 2021 and 2024 were retrieved from PubMed, IEEEXplore and Web of Science, using search terms related to Alzheimer’s disease classification, neuroimaging, machine learning, and diagnostic performance. A total of 39 studies met the inclusion criteria, focusing on the use of Magnetic Resonance Imaging, Positron Emission Tomography, and biomarkers for Alzheimer’s disease classification using machine learning models.

Results

Multimodal approaches, combining Magnetic Resonance Imaging with Positron Emission Tomography and Cognitive assessments, outperformed single-modality studies in diagnostic accuracy reliability. Convolutional Neural Networks were the most commonly used machine learning models, followed by hybrid models and Random Forest. The highest accuracy reported for binary classification was 100%, while multi-class classification achieved up to 99.98%. Techniques like Synthetic Minority Over-sampling Technique and data augmentation were frequently employed to handle data imbalance, improving model generalizability.

Discussion

Our review highlights the advantages of using multimodal data in computer-aided decision support systems for more accurate Alzheimer’s disease diagnosis. However, we also identified several limitations, including data imbalance, small sample sizes, and the lack of external validation in most studies. Future research should utilize larger, more diverse datasets, include longitudinal data, and validate models in real-world clinical trials. Additionally, explainability is needed in machine learning models to ensure they are interpretable and reliable in clinical settings.

Conclusion

While computer-aided decision support systems show significant promise in improving the early diagnosis of Alzheimer’s disease, further work is needed to enhance their robustness, generalizability, and clinical applicability. By addressing these challenges, computer-aided decision support systems could play a key role in the early detection of Alzheimer’s disease and potentially reduce health care costs.

© 2025 The Author(s). Published by Bentham Science Publishers. 
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode.
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Computer-Aided Decision Support Systems of Alzheimer's Disease Diagnosis - A Systematic Review
Curr. Med. Imaging 21, E15734056359358 (2025); https://doi.org/10.2174/0115734056359358250516101749
/content/journals/cmir/10.2174/0115734056359358250516101749
/content/journals/cmir/10.2174/0115734056359358250516101749
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  • Article Type:     Review Article
Keyword(s): Alzheimer’s Disease; Computer Vision; Computer-Aided Diagnosis Systems; Convolutional Neural Networks; Machine Learning; PRISMA; Random Forest; STARD

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