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Volume 21, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Aims

This study aimed to retrospectively analyze the curative effect and influencing factors of lauromacrogol in the treatment of symptomatic hepatic cysts of <10 cm.

Methods

In this study, a total of 51 patients with symptomatic hepatic cysts (maximum diameter ranging from 5 cm to 10 cm) were included. Polycystic Liver Disease Questionnaire (PLD-Q) was used to evaluate the symptoms of patients prior to treatment. The patients were followed up at 1, 3, 6, and 12 months after treatment. At the 12-month follow-up, patients were asked to fill out the PLD-Q to assess their symptoms. The improvement rate of patients' symptoms was evaluated using a 5-point Likert scale (worse, 1; slight difference, 2; roughly the same, 3; good, and 4; better, 5. Volume reduction rate (VRR) was calculated by measuring the volume of the cyst cavity via ultrasound. Treatment success at the 12-month follow-up was determined using two criteria: symptom improvement and changes in cyst volume. Symptom improvement was assessed using a Likert Scale, with a score greater than 3 points indicating significant improvement. Additionally, a volume reduction rate (VRR) of 50% or more in cyst size (VRR ≥ 50%) was considered an effective treatment outcome. The relationship between the clinical factors and the ultrasonographic manifestations of hepatic cysts, including the initial maximum diameter of the cyst (measured using ultrasound before operation), the initial volume of the cyst, and the formation of septa after sclerosis of the cyst, was analyzed.

Results

All patients completed at least 12 months of follow-up. After a 12-month follow-up, the effective and ineffective rates were 96.1% (49/51) and 3.9% (2/51), respectively. The logistic regression univariate analysis showed significant differences in the initial cyst volume (p = 0.001), the initial maximum diameter of the cyst (p = 0.005), and the interval formation after cyst sclerosis (p = <0.001) between VRR ≥ 50% and VRR < 50%. Logistic regression analysis demonstrated that septa formation after cyst sclerosis was an independent factor related to treatment failure, with an odds ratio of 3.246 (95% confidence interval, 0.784–4.148).

Conclusion

Lauromacrogol is an effective method for hepatic cyst treatment. Septa formation after cyst sclerosis is an independent factor related to ineffective treatment.

© 2025 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2025-06-23
2025-09-28

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References

  1. IijimaT. SuwabeT. SumidaK. HayamiN. MiseK. HoshinoJ. TakaichiK. UbaraY. Prediction of hepatic cyst recurrence after minocycline hydrochloride aspiration sclerotherapy using cyst computed tomography values.Hepatol. Res.201747541942410.1111/hepr.1276327316759
     [Google Scholar]
  2. LabibP.L.Z. ArooriS. BowlesM. StellD. BriggsC. Differentiating simple hepatic cysts from mucinous cystic neoplasms: Radiological features, cyst fluid tumour marker analysis and multidisciplinary team outcomes.Dig. Surg.2017341364210.1159/00044730827384180
     [Google Scholar]
  3. EsoY. FurutaA. TakaiA. TakahashiK. UedaY. MarusawaH. SenoH. Ultrasound-guided microfoam sclerotherapy with polidocanol for symptomatic giant hepatic cyst: Initial experience.Hepatol. Res.201848121055106310.1111/hepr.1320229882287
     [Google Scholar]
  4. GarceaG. RajeshA. DennisonA.R. Surgical management of cystic lesions in the liver.ANZ J. Surg.2013837-851652210.1111/ans.1204922537174
     [Google Scholar]
  5. AksoyS. ErdilI. HocaogluE. InciE. AdasG.T. KemikO. TurkayR. The role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of simple and hydatid cysts of the liver.Niger. J. Clin. Pract.201821221221610.4103/njcp.njcp_296_1629465057
     [Google Scholar]
  6. StarP. ConnorD.E. ParsiK. Novel developments in foam sclerotherapy: Focus on Varithena® (polidocanol endovenous microfoam) in the management of varicose veins.Phlebology201833315016210.1177/026835551668786428166694
     [Google Scholar]
  7. DongY.J. LiuZ.H. ZhouJ.Q. ZhanW.W. Efficacy of lauromacrogol injection for ablation of benign predominantly cystic thyroid nodules and related factors: A prospective study.Korean J. Radiol.202223447948710.3348/kjr.2020.120535345062
     [Google Scholar]
  8. WijnandsT.F.M. GeversT.J.G. LantingaM.A. te MorscheR.H. Schultze KoolL.J. DrenthJ.P.H. Pasireotide does not improve efficacy of aspiration sclerotherapy in patients with large hepatic cysts, a randomized controlled trial.Eur. Radiol.20182862682268910.1007/s00330‑017‑5205‑129318424
     [Google Scholar]
  9. WijnandsT.F.M. GörtjesA.P.M. GeversT.J.G. JenniskensS.F.M. KoolL.J.S. PotthoffA. RonotM. DrenthJ.P.H. Efficacy and safety of aspiration sclerotherapy of simple hepatic cysts: A systematic review.AJR Am. J. Roentgenol.2017208120120710.2214/AJR.16.1613027824501
     [Google Scholar]
  10. NeijenhuisM.K. GeversT.J.G. HoganM.C. KamathP.S. WijnandsT.F.M. van den OuwelandR.C.P.M. EdwardsM.E. SloanJ.A. KievitW. DrenthJ.P.H. Development and validation of a disease-specific questionnaire to assess patient-reported symptoms in polycystic liver disease.Hepatology201664115116010.1002/hep.2854526970415
     [Google Scholar]
  11. BahirwaniR. ReddyK.R. Review article: The evaluation of solitary liver masses.Aliment. Pharmacol. Ther.200828895396510.1111/j.1365‑2036.2008.03805.x18643922
     [Google Scholar]
  12. NeijenhuisM.K. WijnandsT.F.M. KievitW. RonotM. GeversT.J.G. DrenthJ.P.H. Symptom relief and not cyst reduction determines treatment success in aspiration sclerotherapy of hepatic cysts.Eur. Radiol.20192963062306810.1007/s00330‑018‑5851‑y30542749
     [Google Scholar]
  13. GaballaD. MoyerM. Thoughts of the safety and efficacy of EUS-guided cyst ablation with the use of lauromacrogol.Gastrointest. Endosc.2018875136710.1016/j.gie.2017.12.03029655441
     [Google Scholar]
  14. SouftasV.D. KosmidouM. KaranikasM. SouftasD. MenexesG. PrassopoulosP. Symptomatic abdominal simple cysts: Is percutaneous sclerotherapy with hypertonic saline and bleomycin a treatment option?Gastroenterol. Res. Pract.2015201511110.1155/2015/48936325878660
     [Google Scholar]
  15. DayR.J. SanchiricoP.J. PfeifferD.C. Giant hepatic cyst as a cause of gastric outlet obstruction.Radiol. Case Rep.20191491088109210.1016/j.radcr.2019.06.01531338132
     [Google Scholar]
  16. DebsT. KassirR. RecciaI. EliasB. Ben AmorI. IannelliA. GugenheimJ. JohannM. Technical challenges in treating recurrent non-parasitic hepatic cysts.Int. J. Surg.201625444810.1016/j.ijsu.2015.11.05126654896
     [Google Scholar]
  17. EsoY. ShimizuH. TakaiA. TakahashiK. SenoH. Ultrasound-guided polidocanol foam sclerotherapy for symptomatic giant hepatic cyst: A single-center experience.Hepatol. Res.202252655756510.1111/hepr.1376935355375
     [Google Scholar]
  18. WijnandsT.F.M. LantingaM.A. DrenthJ.P.H. Hepatic cyst infection following aspiration sclerotherapy: A case series.J. Gastrointestin. Liver Dis.201423444144410.15403/jgld.2014.1121.234.hcy25532005
     [Google Scholar]
  19. WijnandsT.F.M. SchoenemeierB. PotthoffA. GeversT.J.G. GroenewoudH. GebelM.J. RifaiK. MannsM.P. DrenthJ.P.H. Ethanol sclerotherapy or polidocanol sclerotherapy for symptomatic hepatic cysts.United European Gastroenterol. J.20186691992510.1177/205064061876494030023070
     [Google Scholar]
  20. FurumayaA. van RosmalenB.V. de GraeffJ.J. HaringM.P.D. de MeijerV.E. van GulikT.M. VerheijJ. BesselinkM.G. van DeldenO.M. ErdmannJ.I. Dutch Benign Liver Tumor Group Systematic review on percutaneous aspiration and sclerotherapy versus surgery in symptomatic simple hepatic cysts.HPB2021231112410.1016/j.hpb.2020.07.00532830070
     [Google Scholar]
  21. WijnandsT.F.M. RonotM. GeversT.J.G. BenzimraJ. KoolL.J.S. VilgrainV. DrenthJ.P.H. Predictors of treatment response following aspiration sclerotherapy of hepatic cysts: An international pooled analysis of individual patient data.Eur. Radiol.201727274174810.1007/s00330‑016‑4363‑x27180184
     [Google Scholar]
  22. ChenA.W. LiuS.H. HuangY.Y. WangT. Preliminary experience with more stable polidocanol foam in sclerotherapy of head and neck venous malformations.Dermatol. Surg.201844111421142610.1097/DSS.000000000000158729933299
     [Google Scholar]
  23. JanssenY.F. HaringM.P.D. BastiaannetE. PatijnG.A. KlaaseJ.M. de BoerM.T. KruijffS. de MeijerV.E. Surgical treatment for non-parasitic liver cysts improves quality of life.Surgeon202018525726410.1016/j.surge.2019.09.00831678108
     [Google Scholar]
  24. KisielA. VassD.G. NavarroA. JohnA.K. IsaacJ. MarudanayagamR. MirzaD.F. MuiesanP. RobertsK. SutcliffeR.P. Long-term patient-reported outcomes after laparoscopic fenestration of symptomatic liver cysts.Surg. Laparosc. Endosc. Percutan. Tech.2017274e80e8210.1097/SLE.000000000000044128708767
     [Google Scholar]
  25. AkhanO. IslimF. BalciS. ErbahceciA. AkpınarB. CiftciT. AkinciD. Percutaneous treatment of simple hepatic cysts: The long-term results of PAIR and catheterization techniques as single-session procedures.Cardiovasc. Intervent. Radiol.201639690290810.1007/s00270‑015‑1283‑026714694
     [Google Scholar]
  26. BerntsL.H.P. EchternachS.G. KievitW. RosmanC. DrenthJ.P.H. Clinical response after laparoscopic fenestration of symptomatic hepatic cysts: A systematic review and meta-analysis.Surg. Endosc.201933369170410.1007/s00464‑018‑6490‑830334152
     [Google Scholar]
/content/journals/cmir/10.2174/0115734056356792250610102812
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Efficacy and Related Factors of Ultrasound-guided Lauromacrogol Injection in Treating Symptomatic Hepatic Cysts with a Diameter of <10 cm: A Retrospective Study
Curr. Med. Imaging 21, E15734056356792 (2025); https://doi.org/10.2174/0115734056356792250610102812
/content/journals/cmir/10.2174/0115734056356792250610102812
/content/journals/cmir/10.2174/0115734056356792250610102812
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  • Article Type:     Research Article
Keyword(s): Hepatic cyst; Lauromacrogol; Likert scale; Logistic regression analysis; Sclerotherapy; Ultrasound-guided puncture

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