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2000
Volume 21, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Objective

Fibrosing mediastinitis (FM) is a rare and benign disease affecting the mediastinum and often causes pulmonary hypertension (PH). Timely diagnosis of PH caused by FM is clinically important to mitigate complications such as right heart failure in affected individuals. This retrospective study aimed to analyze the CT imaging characteristics of tuberculosis (TB) related FM in patients with (TB). Additionally, the study investigates the underlying reasons contributing to the manifestation of symptoms.

Methods

From April 2007 to October 2020, high-resolution CT (HRCT) and dual-phase CT pulmonary angiography images of 64 patients with suspected FM diagnosed with PH at a tertiary hospital were examined. The imaging characteristics of these CT scans were analyzed, with a specific focus on the TB-FM involvement of the pulmonary veins, pulmonary arteries, and bronchi (down to the segment level).

Results

HRCT imaging revealed that fibrous tissue inside the mediastinum exhibited minimal or negligible reinforcement in TB-FM and diffuse fibrous infiltration in the mediastinum and hilar areas. Notably, segmental bronchial and pulmonary artery stenosis are more pronounced and frequently co-occurring than lobe-level stenosis. Pulmonary venous stenosis developed outside the pericardium, whereas pulmonary artery stenosis occurred outside the mediastinal pleura. Furthermore, no isolated FM involvement in pulmonary veins was noticed in this cohort.

Conclusion

HRCT imaging of TB-related FM presents unique features in certain regions of the bronchi, pulmonary veins, and pulmonary arteries. Thus, it is imperative to accurately identify fibrous tissue involvement in mediastinal lesions for proper diagnosis and management of TB-FM.

© 2025 The Author(s). Published by Bentham Science Publishers.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2025-01-02
2025-10-29

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/content/journals/cmir/10.2174/0115734056324457241218113104
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Image Findings from Dual-phase Computed Tomography Pulmonary Angiography for Diagnosing Tuberculosis-associated Fibrosing Mediastinitis
Curr. Med. Imaging 21, E15734056324457 (2025); https://doi.org/10.2174/0115734056324457241218113104
/content/journals/cmir/10.2174/0115734056324457241218113104
/content/journals/cmir/10.2174/0115734056324457241218113104
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  • Article Type:     Research Article
Keyword(s): Angiography; Computed tomography; Diagnosis; Fibrosing mediastinitis; Imaging; Tuberculosis

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