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- ISSN: 0929-8673
- E-ISSN: 1875-533X
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Candida Proteases and Their Inhibition Prospects for Antifungal Therapy
- Source: Current Medicinal Chemistry, Volume 8, Issue 8, Jul 2001, p. 941 - 948
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- 01 Jul 2001
Abstract
The rationale for inhibition of the secreted acid proteases (SAP) of Candida fungal species as a novel antifungal strategy is outlined. Enzyme structure-activity relationship data regarding the inhibitor A-70450 are described along with results from in vivo antifungal assays. Developments from protein X-ray crystallographic studies, SAP knock-out genetic studies, and the importance of these new results for drug discovery are reviewed. Finally, inhibition of the Candida SAP enzymes with HIV protease inhibitors and a proposed role in candidiasis of AIDS patients is discussed.
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