Skip to content
2000
image of Recent Advancement of Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis- A Review

Abstract

Fecal Microbiota Transplantation (FMT) involves the transfer of gut microbiota from healthy donors to recipients, aiming to reestablish microbial equilibrium within the gastrointestinal tract. The human gut harbors a complex and diverse microbial ecosystem, comprising bacteria, viruses, and fungi, that is essential for maintaining intestinal homeostasis. Emerging evidence indicates a strong association between gut microbial dysbiosis and the pathogenesis of Ulcerative Colitis (UC). FMT has been shown to modulate microbial composition, alter immune signaling pathways, enhance intestinal barrier function, and influence the production of proinflammatory mediators, thereby affecting disease progression. This review critically examines the efficacy, safety, modulatory factors, combination therapies, and predictive strategies associated with FMT in the context of UC. The findings suggest that FMT represents a highly promising therapeutic modality for UC. Overall, this review aims to provide a comprehensive and impartial synthesis of current knowledge regarding FMT, offering deeper insights into its therapeutic potential and clinical applicability in UC management.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cmc/10.2174/0109298673404225250730100935
2025-08-06
2025-11-04

  • From This Site

    /content/journals/cmc/10.2174/0109298673404225250730100935
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Le Berre C. Honap S. Peyrin-Biroulet L. Ulcerative colitis. Lancet 2023 402 10401 571 584 10.1016/S0140‑6736(23)00966‑2 37573077
    [Google Scholar]
  2. Yamazaki M. Chung H. Xu Y. Qiu H. Trends in the prevalence and incidence of ulcerative colitis in Japan and the US. Int. J. Colorectal Dis. 2023 38 1 135 10.1007/s00384‑023‑04417‑6 37204516
    [Google Scholar]
  3. Battat R. Duijvestein M. Guizzetti L. Choudhary D. Boland B.S. Dulai P.S. Parker C.E. Nguyen T.M. Singh S. Vande Casteele N. Pai R.K. Feagan B.G. Sandborn W.J. Jairath V. Histologic healing rates of medical therapies for ulcerative colitis: A systematic review and meta-analysis of randomized controlled trials. Am. J. Gastroenterol. 2019 114 5 733 745 10.14309/ajg.0000000000000111 30694863
    [Google Scholar]
  4. Burri E. Maillard M.H. Schoepfer A.M. Seibold F. Van Assche G. Rivière P. Laharie D. Manz M. Swiss IBDnet, an official working group of the Swiss Society of Gastroenterology Treatment algorithm for mild and moderate-to-severe ulcerative colitis: An update. Digestion 2020 101 2 15 10.1159/000504092 31945767
    [Google Scholar]
  5. Nomura K. Ishikawa D. Okahara K. Ito S. Haga K. Takahashi M. Arakawa A. Shibuya T. Osada T. Kuwahara-Arai K. Kirikae T. Nagahara A. Bacteroidetes species are correlated with disease activity in ulcerative colitis. J. Clin. Med. 2021 10 8 1749 10.3390/jcm10081749 33920646
    [Google Scholar]
  6. Kelly C.R. Kahn S. Kashyap P. Laine L. Rubin D. Atreja A. Moore T. Wu G. Update on fecal microbiota transplantation 2015: Indications, methodologies, mechanisms, and outlook. Gastroenterology 2015 149 1 223 237 10.1053/j.gastro.2015.05.008 25982290
    [Google Scholar]
  7. Zhang Z. Li Q. Zhang S. Liu Y. Lu G. Wen Q. Cui B. Zhang F. Zhang F. Washed microbiota transplantation targeting both gastrointestinal and extraintestinal symptoms in patients with irritable bowel syndrome. Prog. Neuropsychopharmacol. Biol. Psychiatry 2023 127 110839 10.1016/j.pnpbp.2023.110839 37562707
    [Google Scholar]
  8. Zhang X. Li N. Chen Q. Qin H. Fecal microbiota transplantation modulates the gut flora favoring patients with functional constipation. Front. Microbiol. 2021 12 700718 10.3389/fmicb.2021.700718 34690948
    [Google Scholar]
  9. Colman R.J. Rubin D.T. Fecal microbiota transplantation as therapy for inflammatory bowel disease: A systematic review and meta-analysis. J. Crohn’s Colitis 2014 8 12 1569 1581 10.1016/j.crohns.2014.08.006 25223604
    [Google Scholar]
  10. Quagliariello A. Del Chierico F. Reddel S. Russo A. Onetti Muda A. D’Argenio P. Angelino G. Romeo E. Dall’Oglio L. De Angelis P. Putignani L. All The Other Fmt Opbg Committee Collaborators Fecal microbiota transplant in two ulcerative colitis pediatric cases: Gut microbiota and clinical course correlations. Microorganisms 2020 8 10 1486 10.3390/microorganisms8101486 32992653
    [Google Scholar]
  11. Zhang Y.J. Bousvaros A. Docktor M. Kaplan A. Rufo P.A. Leier M. Weatherly M. Zimmerman L. Nguyen L.T.T. Barton B. Russell G. Alm E.J. Kahn S.A. Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease. medRxiv 2023 10.1101/2023.01.30.23285033
    [Google Scholar]
  12. Schierová D. Březina J. Mrázek J. Fliegerová K.O. Kvasnová S. Bajer L. Drastich P. Gut microbiome changes in patients with active left-sided ulcerative colitis after fecal microbiome transplantation and topical 5-aminosalicylic acid therapy. Cells 2020 9 10 2283 10.3390/cells9102283 33066233
    [Google Scholar]
  13. Sun Z. Li J. Dai Y. Wang W. Shi R. Wang Z. Ding P. Lu Q. Jiang H. Pei W. Zhao X. Guo Y. Liu J. Tan X. Mao T. Indigo naturalis alleviates dextran sulfate sodium-induced colitis in rats via altering gut microbiota. Front. Microbiol. 2020 11 731 10.3389/fmicb.2020.00731 32425906
    [Google Scholar]
  14. Wang M.X. Lin L. Chen Y.D. Zhong Y.P. Lin Y.X. Li P. Tian X. Han B. Xie Z.Y. Liao Q.F. Evodiamine has therapeutic efficacy in ulcerative colitis by increasing Lactobacillus acidophilus levels and acetate production. Pharmacol. Res. 2020 159 104978 10.1016/j.phrs.2020.104978 32485282
    [Google Scholar]
  15. Cortez R.V. Moreira L.N. Padilha M. Bibas M.D. Toma R.K. Porta G. Taddei C.R. Gut Microbiome of children and adolescents with primary sclerosing cholangitis in association with ulcerative colitis. Front. Immunol. 2021 11 598152 10.3389/fimmu.2020.598152 33613519
    [Google Scholar]
  16. Guzzo G.L. Mittinty M.N. Llamas B. Andrews J.M. Weyrich L.S. Individuals with inflammatory bowel disease have an altered gut microbiome composition of fungi and protozoa. Microorganisms 2022 10 10 1910 10.3390/microorganisms10101910 36296186
    [Google Scholar]
  17. Chen Q. Fan Y. Zhang B. Yan C. Zhang Q. Ke Y. Chen Z. Wang L. Shi H. Hu Y. Huang Q. Su J. Xie C. Zhang X. Zhou L. Ren J. Xu H. Capsulized fecal microbiota transplantation induces remission in patients with ulcerative colitis by gut microbial colonization and metabolite regulation. Microbiol. Spectr. 2023 11 3 e04152-22 10.1128/spectrum.04152‑22 37093057
    [Google Scholar]
  18. Bryant R.V. Day A.S. McGrath K.C. Telfer K. Yao C.K. Costello S.P. Fecal microbiota transplantation augmented by a sulfide-reducing diet for refractory ulcerative colitis: A case report with functional metagenomic analysis. JGH Open 2021 5 9 1099 1102 10.1002/jgh3.12623 34584982
    [Google Scholar]
  19. Leonardi I. Paramsothy S. Doron I. Semon A. Kaakoush N.O. Clemente J.C. Faith J.J. Borody T.J. Mitchell H.M. Colombel J.F. Kamm M.A. Iliev I.D. Fungal trans-kingdom dynamics linked to responsiveness to fecal microbiota transplantation (FMT) therapy in ulcerative colitis. Cell Host Microbe 2020 27 5 823 829.e3 10.1016/j.chom.2020.03.006 32298656
    [Google Scholar]
  20. Hsia K. Zhao N. Chung M. Algarrahi K. Montaser Kouhsari L. Fu M. Chen H. Singh S. Michaud D.S. Jangi S. Alterations in the fungal microbiome in ulcerative colitis. Inflamm. Bowel Dis. 2023 29 10 1613 1621 10.1093/ibd/izad082 37221272
    [Google Scholar]
  21. Tian X. Li S. Wang C. Zhang Y. Feng X. Yan Q. Guo R. Wu F. Wu C. Wang Y. Huo X. Ma X. Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease. Microbiome 2024 12 1 130 10.1186/s40168‑024‑01832‑x 39026313
    [Google Scholar]
  22. Jansen D. Falony G. Vieira-Silva S. Simsek C. Marcelis T. Caenepeel C. Machiels K. Raes J. Vermeire S. Matthijnssens J. Community types of the human gut virome are associated with endoscopic outcome in ulcerative colitis. J. Crohn’s Colitis 2023 17 9 1504 1513 10.1093/ecco‑jcc/jjad061 37052201
    [Google Scholar]
  23. Leccese G. Bibi A. Mazza S. Facciotti F. Caprioli F. Landini P. Paroni M. Probiotic Lactobacillus and bifidobacterium strains counteract adherent-invasive Escherichia coli (AIEC) Virulence and Hamper IL-23/Th17 Axis in ulcerative colitis, but not in crohn’s disease. Cells 2020 9 8 1824 10.3390/cells9081824 32752244
    [Google Scholar]
  24. Han T. Hu X. Li K. Zhang D. Zhang Y. Li J. Bifidobacterium infantis maintains genome stability in ulcerative colitis via regulating anaphase-promoting complex subunit 7. Front. Microbiol. 2021 12 761113 10.3389/fmicb.2021.761113 34795654
    [Google Scholar]
  25. Souza E.L.S. Campos C.L.V. Reis D.C. Cassali G.D. Generoso S.V. Cardoso V.N. Azevedo V. Medeiros J.D. Fernandes G.R. Nicoli J.R. Martins F.S. Beneficial effects resulting from oral administration of Escherichia coli Nissle 1917 on a chronic colitis model. Benef. Microbes 2020 11 8 779 790 10.3920/BM2020.0045 33191778
    [Google Scholar]
  26. Li N. Xu S. Zhang S. Zhu Q. Meng X. An W. Fu B. Zhong M. Yang Y. Lin Z. Liu X. Xia J. Wang J. You T. Yan C. Tang H. Zhuang G. Peng Z. MSI2 deficiency in ILC3s attenuates DSS-induced colitis by affecting the intestinal microbiota. Front. Immunol. 2023 13 963379 10.3389/fimmu.2022.963379 36713428
    [Google Scholar]
  27. Hao H. Zhang X. Tong L. Liu Q. Liang X. Bu Y. Gong P. Liu T. Zhang L. Xia Y. Ai L. Yi H. Effect of extracellular vesicles derived from Lactobacillus plantarum Q7 on Gut microbiota and ulcerative colitis in mice. Front. Immunol. 2021 12 777147 10.3389/fimmu.2021.777147 34925349
    [Google Scholar]
  28. Yang J. Ren H. Cao J. Fu J. Wang J. Su Z. Lu S. Sheng K. Wang Y. Gut commensal Lachnospiraceae bacteria contribute to anti-colitis effects of Lactiplantibacillus plantarum exopolysaccharides. Int. J. Biol. Macromol. 2025 309 Pt 1 142815 10.1016/j.ijbiomac.2025.142815 40187461
    [Google Scholar]
  29. Pontarollo G. Kollar B. Mann A. Khuu M.P. Kiouptsi K. Bayer F. Brandão I. Zinina V.V. Hahlbrock J. Malinarich F. Mimmler M. Bhushan S. Marini F. Ruf W. Belheouane M. Baines J.F. Endres K. Reba S.M. Raker V.K. Deppermann C. Welsch C. Bosmann M. Soshnikova N. Chassaing B. Bergentall M. Sommer F. Bäckhed F. Reinhardt C. Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling. Nat. Metab. 2023 5 7 1174 1187 10.1038/s42255‑023‑00828‑5 37414930
    [Google Scholar]
  30. Li H. Wei Y. Li X. Zhang S. Zhang R. Li J. Ma B. Shao S. Lv Z. Ruan H. Zhou H. Yang C. Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis. Acta Pharmacol. Sin. 2022 43 4 919 932 10.1038/s41401‑021‑00726‑0 34262136
    [Google Scholar]
  31. Sha S. Zeng H. Gao H. Shi H. Quan X. Chen F. Liu M. Xu B. Liu X. Adherent-invasive Escherichia coli LF82 aggravated intestinal inflammation in colitis mice by affecting the gut microbiota and Th17/Treg cell differentiation balance. Arch. Microbiol. 2023 205 6 218 10.1007/s00203‑023‑03570‑4 37145326
    [Google Scholar]
  32. Kim S. Lee J.Y. Shin S.G. Kim J.K. Silwal P. Kim Y.J. Shin N.R. Kim P.S. Won M. Lee S.H. Kim S.Y. Sasai M. Yamamoto M. Kim J.M. Bae J.W. Jo E.K. ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota. Autophagy 2021 17 10 2856 2875 10.1080/15548627.2020.1847460 33172329
    [Google Scholar]
  33. Zwolinska-Wcislo M. Brzozowski T. Budak A. Kwiecien S. Sliwowski Z. Drozdowicz D. Trojanowska D. Rudnicka-Sosin L. Mach T. Konturek S.J. Pawlik W.W. Effect of Candida colonization on human ulcerative colitis and the healing of inflammatory changes of the colon in the experimental model of colitis ulcerosa. J. Physiol. Pharmacol. 2009 60 1 107 118 19439813
    [Google Scholar]
  34. Hoarau G. Mukherjee P.K. Gower-Rousseau C. Hager C. Chandra J. Retuerto M.A. Neut C. Vermeire S. Clemente J. Colombel J.F. Fujioka H. Poulain D. Sendid B. Ghannoum M.A. Bacteriome and mycobiome interactions underscore microbial dysbiosis in familial crohn’s disease. MBio 2016 7 5 e01250-16 10.1128/mBio.01250‑16 27651359
    [Google Scholar]
  35. Majzoub M.E. Paramsothy S. Haifer C. Parthasarathy R. Borody T.J. Leong R.W. Kamm M.A. Kaakoush N.O. The phageome of patients with ulcerative colitis treated with donor fecal microbiota reveals markers associated with disease remission. Nat. Commun. 2024 15 1 8979 10.1038/s41467‑024‑53454‑4 39420033
    [Google Scholar]
  36. Sinha A. Li Y. Mirzaei M.K. Shamash M. Samadfam R. King I.L. Maurice C.F. Transplantation of bacteriophages from ulcerative colitis patients shifts the gut bacteriome and exacerbates the severity of DSS colitis. Microbiome 2022 10 1 105 10.1186/s40168‑022‑01275‑2 35799219
    [Google Scholar]
  37. Liang L. Liu L. Zhou W. Yang C. Mai G. Li H. Chen Y. Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway. Clin. Sci 2022 136 6 291 307
    [Google Scholar]
  38. Wu Z. Huang S. Li T. Li N. Han D. Zhang B. Xu Z.Z. Zhang S. Pang J. Wang S. Zhang G. Zhao J. Wang J. Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis. Microbiome 2021 9 1 184 10.1186/s40168‑021‑01115‑9 34493333
    [Google Scholar]
  39. Duncan S.H. Holtrop G. Lobley G.E. Calder A.G. Stewart C.S. Flint H.J. Contribution of acetate to butyrate formation by human faecal bacteria. Br. J. Nutr. 2004 91 6 915 923 10.1079/BJN20041150 15182395
    [Google Scholar]
  40. Barcenilla A. Pryde S.E. Martin J.C. Duncan S.H. Stewart C.S. Henderson C. Flint H.J. Phylogenetic relationships of butyrate-producing bacteria from the human gut. Appl. Environ. Microbiol. 2000 66 4 1654 1661 10.1128/AEM.66.4.1654‑1661.2000 10742256
    [Google Scholar]
  41. Zhao H. Zhou Y. Xu J. Zhang Y. Wang H. Zhao C. Huang H. Yang J. Huang C. Li Y. Wang L. Nie Y. Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation. J. Transl. Med. 2024 22 1 369 10.1186/s12967‑024‑05122‑w 38637862
    [Google Scholar]
  42. Wang L. Cen S. Wang G. Lee Y. Zhao J. Zhang H. Chen W. Acetic acid and butyric acid released in large intestine play different roles in the alleviation of constipation. J. Funct. Foods 2020 69 103953 10.1016/j.jff.2020.103953
    [Google Scholar]
  43. Wu Y. Zheng Y. Wang X. Tang P. Guo W. Ma H. Zhang A. Li D. Xie Y. Wang C.Z. Yao H. Wan J.Y. Yuan C.S. Ginseng-containing sijunzi decoction ameliorates ulcerative colitis by orchestrating gut homeostasis in microbial modulation and intestinal barrier integrity. Am. J. Chin. Med. 2023 51 3 677 699 10.1142/S0192415X23500325 36883990
    [Google Scholar]
  44. Liso M. De Santis S. Verna G. Dicarlo M. Calasso M. Santino A. Gigante I. Eri R. Raveenthiraraj S. Sobolewski A. Palmitessa V. Lippolis A. Mastronardi M. Armentano R. Serino G. De Angelis M. Chieppa M. A specific mutation in Muc2 determines early dysbiosis in colitis-prone winnie mice. Inflamm. Bowel Dis. 2020 26 4 546 556 10.1093/ibd/izz279 31748792
    [Google Scholar]
  45. Li N. Ma P. Li Y. Shang X. Nan X. Shi L. Han X. Liu J. Hong Y. Li Q. Cui J. Li J. Peng G. Gut microbiota-derived 12-ketolithocholic acid suppresses the IL-17A secretion from colonic group 3 innate lymphoid cells to prevent the acute exacerbation of ulcerative colitis. Gut Microbes 2023 15 2 2290315 10.1080/19490976.2023.2290315 38062857
    [Google Scholar]
  46. Fan Q. Guan X. Hou Y. Liu Y. Wei W. Cai X. Zhang Y. Wang G. Zheng X. Hao H. Paeoniflorin modulates gut microbial production of indole-3-lactate and epithelial autophagy to alleviate colitis in mice. Phytomedicine 2020 79 153345 10.1016/j.phymed.2020.153345 33002829
    [Google Scholar]
  47. Liu C.S. Hu Y.X. Luo Z.Y. Qiu C.W. Deng X.H. Chen F.L. Xianglian pill modulates gut microbial production of succinate and induces regulatory T cells to alleviate ulcerative colitis in rats. J. Ethnopharmacol. 2023 303 116007 10.1016/j.jep.2022.116007 36473618
    [Google Scholar]
  48. Wu J. Wei Z. Cheng P. Qian C. Xu F. Yang Y. Wang A. Chen W. Sun Z. Lu Y. Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis. Theranostics 2020 10 23 10665 10679 10.7150/thno.43528 32929373
    [Google Scholar]
  49. Peña-Cearra A. Song D. Castelo J. Palacios A. Lavín J.L. Azkargorta M. Elortza F. Fuertes M. Pascual-Itoiz M.A. Barriales D. Martín-Ruiz I. Fullaondo A. Aransay A.M. Rodríguez H. Palm N.W. Anguita J. Abecia L. Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression. NPJ Biofilms Microbiomes 2023 9 1 74 10.1038/s41522‑023‑00443‑y 37805634
    [Google Scholar]
  50. Lei J. Lv L. Zhong L. Xu F. Su W. Chen Y. Wu Z. He S. Chen Y. The gut microbiota affects anti-TNF responsiveness by activating the NAD + salvage pathway in ulcerative colitis. Adv. Sci. (Weinh.) 2025 12 8 2413128 10.1002/advs.202413128 39739648
    [Google Scholar]
  51. Wen X. Wang H.G. Zhang M.N. Zhang M.H. Wang H. Yang X.Z. Fecal microbiota transplantation ameliorates experimental colitis via gut microbiota and T-cell modulation. World J. Gastroenterol. 2021 27 21 2834 2849 10.3748/wjg.v27.i21.2834 34135557
    [Google Scholar]
  52. Hartikainen A.K. Khan I. Karjalainen E.K. Renkonen-Sinisalo L. Arkkila P. Jalanka J. Lepistö A.H. Satokari R. Microbiota and mucosal gene expression of fecal microbiota transplantation or placebo treated patients with chronic pouchitis. Gut Microbes 2024 16 1 2295445 10.1080/19490976.2023.2295445 38214604
    [Google Scholar]
  53. Zhang B. Magnaye K.M. Stryker E. Moltzau-Anderson J. Porsche C.E. Hertz S. McCauley K.E. Smith B.J. Zydek M. Pollard K.S. Ma A. El-Nachef N. Lynch S.V. Sustained mucosal colonization and fecal metabolic dysfunction by Bacteroides associates with fecal microbial transplant failure in ulcerative colitis patients. Sci. Rep. 2024 14 1 18558 10.1038/s41598‑024‑62463‑8 39122767
    [Google Scholar]
  54. Markandey M. Bajaj A. Verma M. Virmani S. Singh M.K. Gaur P. Das P. Srikanth C.V. Makharia G. Kedia S. Ahuja V. Fecal microbiota transplantation refurbishes the crypt-associated microbiota in ulcerative colitis. iScience 2023 26 5 106738 10.1016/j.isci.2023.106738 37216124
    [Google Scholar]
  55. Dang X.F. Wang Q.-X. Yin Z. Sun L. Yang W.H. Recurrence of moderate to severe ulcerative colitis after fecal microbiota transplantation treatment and the efficacy of re-FMT: A case series. BMC Gastroenterol. 2020 20 1 401 10.1186/s12876‑020‑01548‑w 33243141
    [Google Scholar]
  56. Khanna S. Vazquez-Baeza Y. González A. Weiss S. Schmidt B. Muñiz-Pedrogo D.A. Rainey J.F. III Kammer P. Nelson H. Sadowsky M. Khoruts A. Farrugia S.L. Knight R. Pardi D.S. Kashyap P.C. Changes in microbial ecology after fecal microbiota transplantation for recurrent C. difficile infection affected by underlying inflammatory bowel disease. Microbiome 2017 5 1 55 10.1186/s40168‑017‑0269‑3 28506317
    [Google Scholar]
  57. Huang C. Huang Z. Ding L. Fu Y. Fan J. Mei Q. Lou L. Wang J. Yin N. Lu Y. Guo S. Zeng Y. Fecal microbiota transplantation versus glucocorticoids for the induction of remission in mild to moderate ulcerative colitis. J. Transl. Med. 2022 20 1 354 10.1186/s12967‑022‑03569‑3 35962454
    [Google Scholar]
  58. Tian H. Zhang S. Qin H. Li N. Chen Q. Shanghai Tongji FMT Working Group Long-term safety of faecal microbiota transplantation for gastrointestinal diseases in China. Lancet Gastroenterol. Hepatol. 2022 7 8 702 703 10.1016/S2468‑1253(22)00170‑4 35709800
    [Google Scholar]
  59. Lahtinen P. Jalanka J. Mattila E. Tillonen J. Bergman P. Satokari R. Arkkila P. Fecal microbiota transplantation for the maintenance of remission in patients with ulcerative colitis: A randomized controlled trial. World J. Gastroenterol. 2023 29 17 2666 2678 10.3748/wjg.v29.i17.2666 37213403
    [Google Scholar]
  60. Haifer C. Paramsothy S. Kaakoush N.O. Saikal A. Ghaly S. Yang T. Luu L.D.W. Borody T.J. Leong R.W. Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS): A randomised, double-blind, placebo-controlled trial. Lancet Gastroenterol. Hepatol. 2022 7 2 141 151 10.1016/S2468‑1253(21)00400‑3 34863330
    [Google Scholar]
  61. Wei Z.J. Dong H.B. Ren Y.T. Jiang B. Efficacy and safety of fecal microbiota transplantation for the induction of remission in active ulcerative colitis: A systematic review and meta-analysis of randomized controlled trials. Ann. Transl. Med. 2022 10 14 802 10.21037/atm‑22‑3236 35965832
    [Google Scholar]
  62. Zhang J.T. Zhang N. Dong X.T. Wang X.R. Ma H.W. Liu Y.D. Li M.R. Efficacy and safety of fecal microbiota transplantation for treatment of ulcerative colitis: A post-consensus systematic review and meta-analysis. World J. Clin. Cases 2024 12 21 4691 4702 10.12998/wjcc.v12.i21.4691 39070844
    [Google Scholar]
  63. He R. Li P. Wang J. Cui B. Zhang F. Zhao F. The interplay of gut microbiota between donors and recipients determines the efficacy of fecal microbiota transplantation. Gut Microbes 2022 14 1 2100197 10.1080/19490976.2022.2100197 35854629
    [Google Scholar]
  64. Zhang B. Yang L. Ning H. Cao M. Chen Z. Chen Q. Lian G. Tang H. Wang Q. Wang J. Lin Z. Wen J. Liu Y. Xuan J. Li X. Lin A. He J. Zhang L. Hou X. Zeng Q. Xiao C. A matching strategy to guide donor selection for ulcerative colitis in fecal microbiota transplantation: Meta-analysis and analytic hierarchy process. Microbiol. Spectr. 2023 11 1 e02159-21 10.1128/spectrum.02159‑21 36472435
    [Google Scholar]
  65. Leibovitzh H. Shabat C.S. Hirsch A. Zittan E. Mentella M.C. Petito V. Cohen N.A. Ron Y. Fliss Isakov N. Pfeffer J. Yaakov M. Fanali C. Turchini L. Masucci L. Quaranta G. Kolonimos N. Godneva A. Weinberger A. Scaldaferri F. Maharshak N. Faecal transplantation for ulcerative colitis from diet conditioned donors followed by dietary intervention results in favourable gut microbial profile compared to faecal transplantation alone. J. Crohn’s Colitis 2024 18 10 jjae062 10.1093/ecco‑jcc/jjae062 38720628
    [Google Scholar]
  66. Bénard M.V. Arretxe I. Wortelboer K. Harmsen H.J.M. Davids M. de Bruijn C.M.A. Benninga M.A. Hugenholtz F. Herrema H. Ponsioen C.Y. Anaerobic feces processing for fecal microbiota transplantation improves viability of obligate anaerobes. Microorganisms 2023 11 9 2238 10.3390/microorganisms11092238 37764082
    [Google Scholar]
  67. Shimizu H. Arai K. Asahara T. Takahashi T. Tsuji H. Matsumoto S. Takeuchi I. Kyodo R. Yamashiro Y. Stool preparation under anaerobic conditions contributes to retention of obligate anaerobes: Potential improvement for fecal microbiota transplantation. BMC Microbiol. 2021 21 1 275 10.1186/s12866‑021‑02325‑9 34627158
    [Google Scholar]
  68. Chen Q.Y. Tian H.L. Yang B. Lin Z.L. Zhao D. Ye C. Zhang X.Y. Qin H.L. Li N. Effect of intestinal preparation on the efficacy and safety of fecal microbiota transplantation treatment. Zhonghua Wei Chang Wai Ke Za Zhi 2020 23 Z1 48 55 32594726
    [Google Scholar]
  69. Smith B.J. Piceno Y. Zydek M. Zhang B. Syriani L.A. Terdiman J.P. Kassam Z. Ma A. Lynch S.V. Pollard K.S. El-Nachef N. Strain-resolved analysis in a randomized trial of antibiotic pretreatment and maintenance dose delivery mode with fecal microbiota transplant for ulcerative colitis. Sci. Rep. 2022 12 1 5517 10.1038/s41598‑022‑09307‑5 35365713
    [Google Scholar]
  70. Li Q. Ding X. Liu K. Marcella C. Liu X. Zhang T. Liu Y. Li P. Xiang L. Cui B. Wang J. Bai J. Zhang F. Fecal microbiota transplantation for ulcerative colitis: The optimum timing and gut microbiota as predictors for long-term clinical outcomes. Clin. Transl. Gastroenterol. 2020 11 8 e00224 10.14309/ctg.0000000000000224 32955197
    [Google Scholar]
  71. Pai N. Popov J. Hill L. Hartung E. Grzywacz K. Moayyedi P. Surette M. Lee C. Godin D. Szamosi J.C. Khan W.I. Shah M. Rossi L. Thabane L. Moshkovich M. Figueiredo M. McMaster Pediatric Fecal Microbiota Transplant Research Collaboration Results of the first pilot randomized controlled trial of fecal microbiota transplant in pediatric ulcerative colitis: Lessons, limitations, and future prospects. Gastroenterology 2021 161 2 388 393.e3 10.1053/j.gastro.2021.04.067 33961887
    [Google Scholar]
  72. Zou B. Liu S.X. Li X.S. He J.Y. Dong C. Ruan M.L. Xu L. Bai T. Huang Z.H. Shu S.N. Long-term safety and efficacy of fecal microbiota transplantation in 74 children: A single-center retrospective study. Front Pediatr. 2022 10 964154 10.3389/fped.2022.964154 36304525
    [Google Scholar]
  73. Popov J. Hartung E. Hill L. Chauhan U. Pai N. Pediatric patient and parent perceptions of fecal microbiota transplantation for the treatment of ulcerative colitis. J. Pediatr. Gastroenterol. Nutr. 2021 73 6 684 688 10.1097/MPG.0000000000002995 33230077
    [Google Scholar]
  74. Gu X. Miao Z. Wang Y. Yang Y. Yang T. Xu Y. New Baitouweng decoction combined with fecal microbiota transplantation alleviates DSS-induced colitis in rats by regulating gut microbiota metabolic homeostasis and the STAT3/NF-κB signaling pathway. BMC Complement. Med. Ther. 2022 22 1 307 10.1186/s12906‑022‑03766‑z 36424592
    [Google Scholar]
  75. Liu Z. Wang M. Li J. Liang Y. Jiang K. Hu Y. Gong W. Guo X. Guo Q. Zhu B. Hizikia fusiforme polysaccharides synergized with fecal microbiota transplantation to alleviate gut microbiota dysbiosis and intestinal inflammation. Int. J. Biol. Macromol. 2024 283 Pt 4 137851 10.1016/j.ijbiomac.2024.137851 39566790
    [Google Scholar]
  76. Liu Z. Wang M. Hu Y. Li J. Gong W. Guo X. Song S. Zhu B. Ulva lactuca polysaccharides combined with fecal microbiota transplantation ameliorated dextran sodium sulfate-induced colitis in C57BL / 6J mice. J. Sci. Food Agric. 2025 105 1 422 432 10.1002/jsfa.13839 39212113
    [Google Scholar]
  77. Kedia S. Virmani S. K Vuyyuru S. Kumar P. Kante B. Sahu P. Kaushal K. Farooqui M. Singh M. Verma M. Bajaj A. Markandey M. Sachdeva K. Das P. Makharia G.K. Ahuja V. Faecal microbiota transplantation with anti-inflammatory diet (FMT-AID) followed by anti-inflammatory diet alone is effective in inducing and maintaining remission over 1 year in mild to moderate ulcerative colitis: A randomised controlled trial. Gut 2022 71 12 2401 2413 10.1136/gutjnl‑2022‑327811 35973787
    [Google Scholar]
  78. Shabat C.S. Scaldaferri F. Zittan E. Hirsch A. Mentella M.C. Musca T. Cohen N.A. Ron Y. Fliss Isakov N. Pfeffer J. Yaakov M. Fanali C. Turchini L. Masucci L. Quaranta G. Kolonimos N. Godneva A. Weinberger A. Kopylov U. Levine A. Maharshak N. Use of faecal transplantation with a novel diet for mild to moderate active ulcerative colitis: The CRAFT UC Randomised controlled trial. J. Crohn’s Colitis 2022 16 3 369 378 10.1093/ecco‑jcc/jjab165 34514495
    [Google Scholar]
  79. Tkach S. Dorofeyev A. Kuzenko I. Falalyeyeva T. Tsyryuk O. Kovalchuk O. Kobyliak N. Abenavoli L. Boccuto L. Efficacy and safety of fecal microbiota transplantation via colonoscopy as add-on therapy in patients with mild-to-moderate ulcerative colitis: A randomized clinical trial. Front. Med. (Lausanne) 2023 9 1049849 10.3389/fmed.2022.1049849 36714101
    [Google Scholar]
  80. Jo Y.J. Tagele S.B. Pham H.Q. Jung Y. Ibal J.C. Choi S. Kang G.U. Park S. Kang Y. Kim S. Koh H. Shin J.H. In situ profiling of the three dominant phyla within the human gut using TaqMan PCR for pre-hospital diagnosis of gut dysbiosis. Int. J. Mol. Sci. 2020 21 6 1916 10.3390/ijms21061916 32168885
    [Google Scholar]
  81. Galipeau H.J. Caminero A. Turpin W. Bermudez-Brito M. Santiago A. Libertucci J. Constante M. Raygoza Garay J.A. Rueda G. Armstrong S. Clarizio A. Smith M.I. Surette M.G. Bercik P. Croitoru K. Verdu E.F. Beck P. Bernstein C. Croitoru K. Dieleman L. Feagan B. Griffiths A. Guttman D. Jacobson K. Kaplan G. Krause D.O. Madsen K. Marshall J. Moayyedi P. Ropeleski M. Seidman E. Silverberg M. Snapper S. Stadnyk A. Steinhart H. Surette M. Turner D. Walters T. Vallance B. Aumais G. Bitton A. Cino M. Critch J. Denson L. Deslandres C. El-Matary W. Herfarth H. Higgins P. Huynh H. Hyams J. Mack D. McGrath J. Otley A. Panancionne R. CCC Genetics, Environmental, Microbial Project Research Consortium Novel fecal biomarkers that precede clinical diagnosis of ulcerative colitis. Gastroenterology 2021 160 5 1532 1545 10.1053/j.gastro.2020.12.004 33310084
    [Google Scholar]
  82. Luu L.D.W. Pandey A. Paramsothy S. Ngo C. Castaño-Rodríguez N. Liu C. Kamm M.A. Borody T.J. Man S.M. Kaakoush N.O. Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice. Nat. Commun. 2024 15 1 2645 10.1038/s41467‑024‑46983‑5 38531874
    [Google Scholar]
  83. Ren R. Gao X. Shi Y. Li J. Peng L. Sun G. Wang Z. Yan B. Zhi J. Yang Y. Long-term efficacy of low-intensity single donor fecal microbiota transplantation in ulcerative colitis and outcome-specific gut bacteria. Front. Microbiol. 2021 12 742255 10.3389/fmicb.2021.742255 34867859
    [Google Scholar]
  84. Lopetuso L.R. Laterza L. Petito V. Pecere S. Quaranta G. Del Chierico F. Puca P. Schiavoni E. Napolitano D. Poscia A. Ianiro G. Pugliese D. Putignani L. Sanguinetti M. Armuzzi A. Masucci L. Gasbarrini A. Cammarota G. Scaldaferri F. Serial fecal microbiota infusions via colonoscopy for active ulcerative colitis: A feasibility, safety, and translational monocentric italian study. Microorganisms 2023 11 10 2536 10.3390/microorganisms11102536 37894194
    [Google Scholar]
  85. Zhang Y.J. Bousvaros A. Docktor M. Kaplan A.L. Rufo P.A. Leier M. Weatherly M. Zimmerman L. Nguyen L.T.T. Barton B. Russell G. Alm E.J. Kahn S.A. Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease. Sci. Rep. 2024 14 1 18188 10.1038/s41598‑024‑68619‑w 39107366
    [Google Scholar]
  86. Kang G.U. Park S. Jung Y. Jee J.J. Kim M.S. Lee S. Lee D.W. Shin J.H. Koh H. Exploration of potential gut microbiota-derived biomarkers to predict the success of fecal microbiota transplantation in ulcerative colitis: A prospective cohort in korea. Gut Liver 2022 16 5 775 785 10.5009/gnl210369 35975640
    [Google Scholar]
  87. Wu X. Li P. Wang W. Xu J. Ai R. Wen Q. Cui B. Zhang F. The Underlying changes in serum metabolic profiles and efficacy prediction in patients with extensive ulcerative colitis undergoing fecal microbiota transplantation. Nutrients 2023 15 15 3340 10.3390/nu15153340 37571277
    [Google Scholar]
/content/journals/cmc/10.2174/0109298673404225250730100935
Loading
Recent Advancement of Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis- A Review
Bentham Science Publishers ; https://doi.org/10.2174/0109298673404225250730100935
/content/journals/cmc/10.2174/0109298673404225250730100935
/content/journals/cmc/10.2174/0109298673404225250730100935
Loading

Data & Media loading...


  • Article Type:     Review Article
Keywords: gut microbiota ; Ulcerative colitis ; dysbiosis ; treatment efficacy ; fecal microbiota transplantation ; inflammation

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test