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image of Decoding PRTFDC1's Role in Lung Adenocarcinoma: From Gene Expression to Clinical Implications

Abstract

Introduction

This study aims to elucidate the role of Phosphoribosyl Transferase Domain Containing 1 (PRTFDC1) in Lung Adenocarcinoma (LUAD) through bioinformatics analysis and experimental validation, exploring its potential as a biomarker for prognosis and treatment response.

Methods

We analyzed PRTFDC1 gene expression patterns in 539 LUAD and 59 normal lung tissue samples from The Cancer Genome Atlas (TCGA). Using bioinformatics tools, we examined the correlation between PRTFDC1 expression and clinical characteristics, immune infiltration, Tumor Mutation Burden (TMB), and drug responsiveness. Experimental validation was conducted in LUAD cell lines (A549 and HCC-78) through the overexpression of PRTFDC1, followed by cell proliferation and cell cycle assays.

Results

PRTFDC1 expression was significantly elevated in LUAD compared to normal tissues, correlating with poorer Progression-Free Survival (PFS) and Disease-Specific Survival (DSS). PRTFDC1 was associated with immune cell infiltration, TMB, and mRNA stemness index (mRNAsi). Overexpression of PRTFDC1 in LUAD cell lines promoted cell proliferation and cell cycle progression, mediated by Threonine Tyrosine Kinase (TTK).

Discussion

The findings suggest that PRTFDC1 may serve as an independent prognostic marker for LUAD, influencing tumor progression and immune response. The correlation with TTK indicates a potential mechanism for PRTFDC1's impact on cell proliferation. However, further research is needed to validate these findings in larger cohorts and explore the underlying molecular mechanisms.

Conclusion

PRTFDC1 is a promising biomarker for LUAD prognosis and treatment response, with potential implications for targeted therapies and personalized medicine.

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2025-08-22
2025-11-04

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References

  1. Chen W. Zheng R. Baade P.D. Zhang S. Zeng H. Bray F. Jemal A. Yu X.Q. He J. Cancer statistics in China, 2015. CA. Cancer. J. Clin. 2016 66 2 115 132 10.3322/caac.21338 26808342
    [Google Scholar]
  2. Sung H. Ferlay J. Siegel R.L. Laversanne M. Soerjomataram I. Jemal A. Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA. Cancer. J. Clin. 2021 71 3 209 249 10.3322/caac.21660 33538338
    [Google Scholar]
  3. Cao W. Chen H.D. Yu Y.W. Li N. Chen W.Q. Changing profiles of cancer burden worldwide and in China: A secondary analysis of the global cancer statistics 2020. Chin. Med. J. 2021 134 7 783 791 10.1097/CM9.0000000000001474 33734139
    [Google Scholar]
  4. Shi Y. Chen W. Li C. Qi S. Zhou X. Zhang Y. Li Y. Li G. Clinicopathological characteristics and prediction of cancer-specific survival in large cell lung cancer: A population-based study. J. Thorac. Dis. 2020 12 5 2261 2269 10.21037/jtd.2020.04.24 32642131
    [Google Scholar]
  5. Liu Z. Han S. Luo Y. Zhao Z. Ni L. Chai L. Tang H. PERP may affect the prognosis of lung adenocarcinoma by inhibiting apoptosis. Cancer. Manag. Res. 2024 16 199 214 10.2147/CMAR.S443490 38525370
    [Google Scholar]
  6. Zhuo T. Wu Z. Chen S. Yang C. Huang H. Gan J. Lyu J. Xiao J. Li Z. Qin S. Wu Y. NEDD1 overexpression increases cell proliferation, tumor immune escape, and drug resistance in LUAD. J. Cancer. 2024 15 9 2460 2474 10.7150/jca.91671 38577589
    [Google Scholar]
  7. Zappa C. Mousa S.A. Non-small cell lung cancer: Current treatment and future advances. Transl. Lung. Cancer. Res. 2016 5 3 288 300 10.21037/tlcr.2016.06.07 27413711
    [Google Scholar]
  8. Ou S.H.I. Zell J.A. Ziogas A. Anton-Culver H. Prognostic factors for survival of stage I nonsmall cell lung cancer patients. Cancer 2007 110 7 1532 1541 10.1002/cncr.22938 17702091
    [Google Scholar]
  9. Yang X. Zhu X. G2 and S phase-expressed protein 1 is a biomarker for poor prognosis in lung adenocarcinoma. Medicine 2024 103 12 e37358 10.1097/MD.0000000000037358 38518054
    [Google Scholar]
  10. Suzuki E. Imoto I. Pimkhaokham A. Nakagawa T. Kamata N. Kozaki K. Amagasa T. Inazawa J. PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. Oncogene 2007 26 57 7921 7932 10.1038/sj.onc.1210589 17599052
    [Google Scholar]
  11. Cai L. Abe M. Izumi S. Imura M. Yasugi T. Ushijima T. Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers. Life Sci 2007 80 16 1458 1465 10.1016/j.lfs.2007.01.015 17303177
    [Google Scholar]
  12. Keebaugh A.C. Mitchell H.A. Gaval-Cruz M. Freeman K.G. Edwards G.L. Weinshenker D. Thomas J.W. PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse. PLoS One 2011 6 7 e22381 10.1371/journal.pone.0022381 21818316
    [Google Scholar]
  13. Nievergelt C.M. Maihofer A.X. Mustapic M. Yurgil K.A. Schork N.J. Miller M.W. Logue M.W. Geyer M.A. Risbrough V.B. O’Connor D.T. Baker D.G. Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene. Psychoneuroendocrinology 2015 51 459 471 10.1016/j.psyneuen.2014.10.017 25456346
    [Google Scholar]
  14. Han Q. Cui Z. Wang Q. Pang F. Li D. Wang D. Upregulation of OTX2-AS1 is associated with immune infiltration and predicts prognosis of gastric cancer. Technol. Cancer. Res. Treat. 2023 22 15330338231154091 10.1177/15330338231154091 36740995
    [Google Scholar]
  15. Chen Y.C. Li D.B. Wang D.L. Peng H. Comprehensive analysis of distal-less homeobox family gene expression in colon cancer. World. J. Gastrointest Oncol. 2023 15 6 1019 1035 10.4251/wjgo.v15.i6.1019 37389108
    [Google Scholar]
  16. Vivian J. Rao A.A. Nothaft F.A. Ketchum C. Armstrong J. Novak A. Pfeil J. Narkizian J. Deran A.D. Musselman-Brown A. Schmidt H. Amstutz P. Craft B. Goldman M. Rosenbloom K. Cline M. O’Connor B. Hanna M. Birger C. Kent W.J. Patterson D.A. Joseph A.D. Zhu J. Zaranek S. Getz G. Haussler D. Paten B. Toil enables reproducible, open source, big biomedical data analyses. Nat. Biotechnol. 2017 35 4 314 316 10.1038/nbt.3772 28398314
    [Google Scholar]
  17. Xing S. Li D. Zhao Q. RPL22L1 is a novel biomarker for prognosis and immune infiltration in lung adenocarcinoma, promoting the growth and metastasis of LUAD cells by inhibiting the MDM2/P53 signaling pathway. Aging 2024 16 17 12392 12413 10.18632/aging.206096 39207452
    [Google Scholar]
  18. Bindea G. Mlecnik B. Tosolini M. Kirilovsky A. Waldner M. Obenauf A.C. Angell H. Fredriksen T. Lafontaine L. Berger A. Bruneval P. Fridman W.H. Becker C. Pagès F. Speicher M.R. Trajanoski Z. Galon J. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 2013 39 4 782 795 10.1016/j.immuni.2013.10.003 24138885
    [Google Scholar]
  19. Yoshihara K. Shahmoradgoli M. Martínez E. Vegesna R. Kim H. Torres-Garcia W. Treviño V. Shen H. Laird P.W. Levine D.A. Carter S.L. Getz G. Stemke-Hale K. Mills G.B. Verhaak R.G.W. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat. Commun. 2013 4 1 2612 10.1038/ncomms3612 24113773
    [Google Scholar]
  20. Thorsson V. Gibbs D.L. Brown S.D. Wolf D. Bortone D.S. Ou Yang T.H. Porta-Pardo E. Gao G.F. Plaisier C.L. Eddy J.A. Ziv E. Culhane A.C. Paull E.O. Sivakumar I.K.A. Gentles A.J. Malhotra R. Farshidfar F. Colaprico A. Parker J.S. Mose L.E. Vo N.S. Liu J. Liu Y. Rader J. Dhankani V. Reynolds S.M. Bowlby R. Califano A. Cherniack A.D. Anastassiou D. Bedognetti D. Mokrab Y. Newman A.M. Rao A. Chen K. Krasnitz A. Hu H. Malta T.M. Noushmehr H. Pedamallu C.S. Bullman S. Ojesina A.I. Lamb A. Zhou W. Shen H. Choueiri T.K. Weinstein J.N. Guinney J. Saltz J. Holt R.A. Rabkin C.S. Lazar A.J. Serody J.S. Demicco E.G. Disis M.L. Vincent B.G. Shmulevich I. Caesar-Johnson S.J. Demchok J.A. Felau I. Kasapi M. Ferguson M.L. Hutter C.M. Sofia H.J. Tarnuzzer R. Wang Z. Yang L. Zenklusen J.C. Zhang J.J. Chudamani S. Liu J. Lolla L. Naresh R. Pihl T. Sun Q. Wan Y. Wu Y. Cho J. DeFreitas T. Frazer S. Gehlenborg N. Getz G. Heiman D.I. Kim J. Lawrence M.S. Lin P. Meier S. Noble M.S. Saksena G. Voet D. Zhang H. Bernard B. Chambwe N. Dhankani V. Knijnenburg T. Kramer R. Leinonen K. Liu Y. Miller M. Reynolds S. Shmulevich I. Thorsson V. Zhang W. Akbani R. Broom B.M. Hegde A.M. Ju Z. Kanchi R.S. Korkut A. Li J. Liang H. Ling S. Liu W. Lu Y. Mills G.B. Ng K-S. Rao A. Ryan M. Wang J. Weinstein J.N. Zhang J. Abeshouse A. Armenia J. Chakravarty D. Chatila W.K. de Bruijn I. Gao J. Gross B.E. Heins Z.J. Kundra R. La K. Ladanyi M. Luna A. Nissan M.G. Ochoa A. Phillips S.M. Reznik E. Sanchez-Vega F. Sander C. Schultz N. Sheridan R. Sumer S.O. Sun Y. Taylor B.S. Wang J. Zhang H. Anur P. Peto M. Spellman P. Benz C. Stuart J.M. Wong C.K. Yau C. Hayes D.N. Parker J.S. Wilkerson M.D. Ally A. Balasundaram M. Bowlby R. Brooks D. Carlsen R. Chuah E. Dhalla N. Holt R. Jones S.J.M. Kasaian K. Lee D. Ma Y. Marra M.A. Mayo M. Moore R.A. Mungall A.J. Mungall K. Robertson A.G. Sadeghi S. Schein J.E. Sipahimalani P. Tam A. Thiessen N. Tse K. Wong T. Berger A.C. Beroukhim R. Cherniack A.D. Cibulskis C. Gabriel S.B. Gao G.F. Ha G. Meyerson M. Schumacher S.E. Shih J. Kucherlapati M.H. Kucherlapati R.S. Baylin S. Cope L. Danilova L. Bootwalla M.S. Lai P.H. Maglinte D.T. Van Den Berg D.J. Weisenberger D.J. Auman J.T. Balu S. Bodenheimer T. Fan C. Hoadley K.A. Hoyle A.P. Jefferys S.R. Jones C.D. Meng S. Mieczkowski P.A. Mose L.E. Perou A.H. Perou C.M. Roach J. Shi Y. Simons J.V. Skelly T. Soloway M.G. Tan D. Veluvolu U. Fan H. Hinoue T. Laird P.W. Shen H. Zhou W. Bellair M. Chang K. Covington K. Creighton C.J. Dinh H. Doddapaneni H.V. Donehower L.A. Drummond J. Gibbs R.A. Glenn R. Hale W. Han Y. Hu J. Korchina V. Lee S. Lewis L. Li W. Liu X. Morgan M. Morton D. Muzny D. Santibanez J. Sheth M. Shinbrot E. Wang L. Wang M. Wheeler D.A. Xi L. Zhao F. Hess J. Appelbaum E.L. Bailey M. Cordes M.G. Ding L. Fronick C.C. Fulton L.A. Fulton R.S. Kandoth C. Mardis E.R. McLellan M.D. Miller C.A. Schmidt H.K. Wilson R.K. Crain D. Curley E. Gardner J. Lau K. Mallery D. Morris S. Paulauskis J. Penny R. Shelton C. Shelton T. Sherman M. Thompson E. Yena P. Bowen J. Gastier-Foster J.M. Gerken M. Leraas K.M. Lichtenberg T.M. Ramirez N.C. Wise L. Zmuda E. Corcoran N. Costello T. Hovens C. Carvalho A.L. de Carvalho A.C. Fregnani J.H. Longatto-Filho A. Reis R.M. Scapulatempo-Neto C. Silveira H.C.S. Vidal D.O. Burnette A. Eschbacher J. Hermes B. Noss A. Singh R. Anderson M.L. Castro P.D. Ittmann M. Huntsman D. Kohl B. Le X. Thorp R. Andry C. Duffy E.R. Lyadov V. Paklina O. Setdikova G. Shabunin A. Tavobilov M. McPherson C. Warnick R. Berkowitz R. Cramer D. Feltmate C. Horowitz N. Kibel A. Muto M. Raut C.P. Malykh A. Barnholtz-Sloan J.S. Barrett W. Devine K. Fulop J. Ostrom Q.T. Shimmel K. Wolinsky Y. Sloan A.E. De Rose A. Giuliante F. Goodman M. Karlan B.Y. Hagedorn C.H. Eckman J. Harr J. Myers J. Tucker K. Zach L.A. Deyarmin B. Hu H. Kvecher L. Larson C. Mural R.J. Somiari S. Vicha A. Zelinka T. Bennett J. Iacocca M. Rabeno B. Swanson P. Latour M. Lacombe L. Têtu B. Bergeron A. McGraw M. Staugaitis S.M. Chabot J. Hibshoosh H. Sepulveda A. Su T. Wang T. Potapova O. Voronina O. Desjardins L. Mariani O. Roman-Roman S. Sastre X. Stern M-H. Cheng F. Signoretti S. Berchuck A. Bigner D. Lipp E. Marks J. McCall S. McLendon R. Secord A. Sharp A. Behera M. Brat D.J. Chen A. Delman K. Force S. Khuri F. Magliocca K. Maithel S. Olson J.J. Owonikoko T. Pickens A. Ramalingam S. Shin D.M. Sica G. Van Meir E.G. Zhang H. Eijckenboom W. Gillis A. Korpershoek E. Looijenga L. Oosterhuis W. Stoop H. van Kessel K.E. Zwarthoff E.C. Calatozzolo C. Cuppini L. Cuzzubbo S. DiMeco F. Finocchiaro G. Mattei L. Perin A. Pollo B. Chen C. Houck J. Lohavanichbutr P. Hartmann A. Stoehr C. Stoehr R. Taubert H. Wach S. Wullich B. Kycler W. Murawa D. Wiznerowicz M. Chung K. Edenfield W.J. Martin J. Baudin E. Bubley G. Bueno R. De Rienzo A. Richards W.G. Kalkanis S. Mikkelsen T. Noushmehr H. Scarpace L. Girard N. Aymerich M. Campo E. Giné E. Guillermo A.L. Van Bang N. Hanh P.T. Phu B.D. Tang Y. Colman H. Evason K. Dottino P.R. Martignetti J.A. Gabra H. Juhl H. Akeredolu T. Stepa S. Hoon D. Ahn K. Kang K.J. Beuschlein F. Breggia A. Birrer M. Bell D. Borad M. Bryce A.H. Castle E. Chandan V. Cheville J. Copland J.A. Farnell M. Flotte T. Giama N. Ho T. Kendrick M. Kocher J-P. Kopp K. Moser C. Nagorney D. O’Brien D. O’Neill B.P. Patel T. Petersen G. Que F. Rivera M. Roberts L. Smallridge R. Smyrk T. Stanton M. Thompson R.H. Torbenson M. Yang J.D. Zhang L. Brimo F. Ajani J.A. Gonzalez A.M.A. Behrens C. Bondaruk J. Broaddus R. Czerniak B. Esmaeli B. Fujimoto J. Gershenwald J. Guo C. Lazar A.J. Logothetis C. Meric-Bernstam F. Moran C. Ramondetta L. Rice D. Sood A. Tamboli P. Thompson T. Troncoso P. Tsao A. Wistuba I. Carter C. Haydu L. Hersey P. Jakrot V. Kakavand H. Kefford R. Lee K. Long G. Mann G. Quinn M. Saw R. Scolyer R. Shannon K. Spillane A. Stretch Synott M. Thompson J. Wilmott J. Al-Ahmadie H. Chan T.A. Ghossein R. Gopalan A. Levine D.A. Reuter V. Singer S. Singh B. Tien N.V. Broudy T. Mirsaidi C. Nair P. Drwiega P. Miller J. Smith J. Zaren H. Park J-W. Hung N.P. Kebebew E. Linehan W.M. Metwalli A.R. Pacak K. Pinto P.A. Schiffman M. Schmidt L.S. Vocke C.D. Wentzensen N. Worrell R. Yang H. Moncrieff M. Goparaju C. Melamed J. Pass H. Botnariuc N. Caraman I. Cernat M. Chemencedji I. Clipca A. Doruc S. Gorincioi G. Mura S. Pirtac M. Stancul I. Tcaciuc D. Albert M. Alexopoulou I. Arnaout A. Bartlett J. Engel J. Gilbert S. Parfitt J. Sekhon H. Thomas G. Rassl D.M. Rintoul R.C. Bifulco C. Tamakawa R. Urba W. Hayward N. Timmers H. Antenucci A. Facciolo F. Grazi G. Marino M. Merola R. de Krijger R. Gimenez-Roqueplo A-P. Piché A. Chevalier S. McKercher G. Birsoy K. Barnett G. Brewer C. Farver C. Naska T. Pennell N.A. Raymond D. Schilero C. Smolenski K. Williams F. Morrison C. Borgia J.A. Liptay M.J. Pool M. Seder C.W. Junker K. Omberg L. Dinkin M. Manikhas G. Alvaro D. Bragazzi M.C. Cardinale V. Carpino G. Gaudio E. Chesla D. Cottingham S. Dubina M. Moiseenko F. Dhanasekaran R. Becker K-F. Janssen K-P. Slotta-Huspenina J. Abdel-Rahman M.H. Aziz D. Bell S. Cebulla C.M. Davis A. Duell R. Elder J.B. Hilty J. Kumar B. Lang J. Lehman N.L. Mandt R. Nguyen P. Pilarski R. Rai K. Schoenfield L. Senecal K. Wakely P. Hansen P. Lechan R. Powers J. Tischler A. Grizzle W.E. Sexton K.C. Kastl A. Henderson J. Porten S. Waldmann J. Fassnacht M. Asa S.L. Schadendorf D. Couce M. Graefen M. Huland H. Sauter G. Schlomm T. Simon R. Tennstedt P. Olabode O. Nelson M. Bathe O. Carroll P.R. Chan J.M. Disaia P. Glenn P. Kelley R.K. Landen C.N. Phillips J. Prados M. Simko J. Smith-McCune K. VandenBerg S. Roggin K. Fehrenbach A. Kendler A. Sifri S. Steele R. Jimeno A. Carey F. Forgie I. Mannelli M. Carney M. Hernandez B. Campos B. Herold-Mende C. Jungk C. Unterberg A. von Deimling A. Bossler A. Galbraith J. Jacobus L. Knudson M. Knutson T. Ma D. Milhem M. Sigmund R. Godwin A.K. Madan R. Rosenthal H.G. Adebamowo C. Adebamowo S.N. Boussioutas A. Beer D. Giordano T. Mes-Masson A-M. Saad F. Bocklage T. Landrum L. Mannel R. Moore K. Moxley K. Postier R. Walker J. Zuna R. Feldman M. Valdivieso F. Dhir R. Luketich J. Pinero E.M.M. Quintero-Aguilo M. Carlotti C.G. Dos Santos J.S. Kemp R. Sankarankuty A. Tirapelli D. Catto J. Agnew K. Swisher E. Creaney J. Robinson B. Shelley C.S. Godwin E.M. Kendall S. Shipman C. Bradford C. Carey T. Haddad A. Moyer J. Peterson L. Prince M. Rozek L. Wolf G. Bowman R. Fong K.M. Yang I. Korst R. Rathmell W.K. Fantacone-Campbell J.L. Hooke J.A. Kovatich A.J. Shriver C.D. DiPersio J. Drake B. Govindan R. Heath S. Ley T. Van Tine B. Westervelt P. Rubin M.A. Lee J.I. Aredes N.D. Mariamidze A. The immune landscape of cancer. Immunity 2018 48 4 812 830.e14 10.1016/j.immuni.2018.03.023 29628290
    [Google Scholar]
  21. Zhao W. Ou G. Lin W. Integrative analysis of neuregulin family members-related tumor microenvironment for predicting the prognosis in gliomas. Front. Immunol. 2021 12 682415 10.3389/fimmu.2021.682415 34054873
    [Google Scholar]
  22. Wang C. Zhao Z. Zhang Y. Liang W. Zhou C. Lin W. He Y. Wu M. Meng Z. Liao Y. Li M. El Akkawi M. Zhao J. He Y. Identification and verification of the prognostic value of CUL7 in colon adenocarcinoma. Front. Immunol. 2022 13 1043512 10.3389/fimmu.2022.1043512 36304472
    [Google Scholar]
  23. Chen B. Ding X. Wan A. Qi X. Lin X. Wang H. Mu W. Wang G. Zheng J. Comprehensive analysis of TLX2 in pan cancer as a prognostic and immunologic biomarker and validation in ovarian cancer. Sci. Rep. 2023 13 1 16244 10.1038/s41598‑023‑42171‑5 37758722
    [Google Scholar]
  24. Yang D. Liu M. Jiang J. Luo Y. Wang Y. Chen H. Li D. Wang D. Yang Z. Chen H. Comprehensive analysis of DMRT3 as a potential biomarker associated with the immune infiltration in a pan-cancer analysis and validation in lung adenocarcinoma. Cancers 2022 14 24 6220 10.3390/cancers14246220 36551704
    [Google Scholar]
  25. Ding X. Wan A. Qi X. Jiang K. Liu Z. Chen B. ZNF695, A potential prognostic biomarker, correlates with im mune infiltrates in cervical squamous cell carcinoma and endoce rvical adenocarcinoma: Bioinformatic analysis and experimental verification. Curr. Gene. Ther. 2024 24 5 441 452 10.2174/0115665232285216240228071244 38441026
    [Google Scholar]
  26. Jin W. Sun Y. Wang J. Wang Y. Chen D. Fang M. He J. Zhong L. Ren H. Zhang Y. Yin H. Wu S. Chen R. Yan W. Arsenic trioxide suppresses lung adenocarcinoma stem cell stemness by inhibiting m6A modification to promote ferroptosis. Am. J. Cancer. Res. 2024 14 2 507 525 10.62347/KFAX9239 38455419
    [Google Scholar]
  27. Cai H. Chen S. Wu Z. Wang F. Tang S. Li D. Wang D. Guo W. Comprehensive analysis of ZNF692 as a potential biomarker associated with immune infiltration in a pan cancer analysis and validation in hepatocellular carcinoma. Aging 2023 15 22 13041 13058 10.18632/aging.205218 37980166
    [Google Scholar]
  28. Li Z. Fan Y. Ma Y. Meng N. Li D. Wang D. Lian J. Hu C. Identification of crucial genes and signaling pathways in alectinib-resistant lung adenocarcinoma using bioinformatic analysis. Mol. Biotechnol. 2023 10.1007/s12033‑023‑00973‑y 38142454
    [Google Scholar]
  29. Li Y. Lyu G. Construction of a PANoptosis-related prognostic signature for predicting prognosis, tumor microenvironment, and immune response in ovarian cancer. Curr. Med. Chem. 2024 31 10.2174/0109298673314864240829064622 39248067
    [Google Scholar]
  30. Huang D. Wang Y. Thompson J.W. Yin T. Alexander P.B. Qin D. Mudgal P. Wu H. Liang Y. Tan L. Pan C. Yuan L. Wan Y. Li Q.J. Wang X.F. Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression. Nat. Cell. Biol. 2022 24 2 230 241 10.1038/s41556‑021‑00820‑9 35145222
    [Google Scholar]
  31. He W. Dong S. Shen J. Wu J. Zhao P. Li D. Wang D. Tang N. Zou C. Whole-genome sequencing identified novel mutations in a Chinese family with lynch syndrome. Front. Oncol 2023 13 1036356 10.3389/fonc.2023.1036356 36874103
    [Google Scholar]
  32. Chen P. Liu Y. Wen Y. Zhou C. Non-small cell lung cancer in China. Cancer. Commun. 2022 42 10 937 970 10.1002/cac2.12359 36075878
    [Google Scholar]
  33. Bruni D. Angell H.K. Galon J. The immune contexture and immunoscore in cancer prognosis and therapeutic efficacy. Nat. Rev. Cancer. 2020 20 11 662 680 10.1038/s41568‑020‑0285‑7 32753728
    [Google Scholar]
  34. Munro M.J. Wickremesekera S.K. Peng L. Tan S.T. Itinteang T. Cancer stem cells in colorectal cancer: A review. J. Clin. Pathol. 2018 71 2 110 116 10.1136/jclinpath‑2017‑204739 28942428
    [Google Scholar]
  35. Wang L. Liu W. Liu J. Wang Y. Tai J. Yin X. Tan J. Identification of immune-related therapeutically relevant biomarkers in breast cancer and breast cancer stem cells by transcriptome-wide analysis: A clinical prospective study. Front. Oncol. 2021 10 554138 10.3389/fonc.2020.554138 33718103
    [Google Scholar]
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Decoding PRTFDC1's Role in Lung Adenocarcinoma: From Gene Expression to Clinical Implications
Bentham Science Publishers ; https://doi.org/10.2174/0109298673367449250728104846
/content/journals/cmc/10.2174/0109298673367449250728104846
/content/journals/cmc/10.2174/0109298673367449250728104846
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  • Article Type:     Research Article
Keywords: immune response ; Lung adenocarcinoma ; prognosis ; PRTFDC1 ; cell cycle ; TTK

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