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2000
Volume 33, Issue 5
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Curcumin is a natural plant pigment that has been widely used in food production, drug development, and textile engineering. Gaining a deep understanding of the biological activities of curcumin and obtaining high-purity curcumin are of vital importance for basic research and applications of curcumin. In this review, we summarize recent advances in curcumin, mainly focusing on the methods of extracting and purifying curcumin from turmeric as well as applications based on biological activity. We systematically describe the advantages and disadvantages of traditional and modern extraction technologies. The usual purification methods include conventional methods (such as macroporous resin column chromatography and silica gel column chromatography, ) and auxiliary modern technologies (such as high-speed countercurrent chromatography and supercritical fluid chromatography). In terms of biological activity, the phenolic hydroxy group and methoxy group of curcumin are closely related to its antioxidant activity, endowing it with strong antibacterial, anti-inflammatory, and antitumor properties. Moreover, the development direction based on its multiple biological activities is also discussed.

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2026-02-25

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References

  1. GoelA. KunnumakkaraA.B. AggarwalB.B. Curcumin as “Curecumin”: From kitchen to clinic.Biochem. Pharmacol.200875478780910.1016/j.bcp.2007.08.01617900536
     [Google Scholar]
  2. JiangT. GhoshR. CharcossetC. Extraction, purification and applications of curcumin from plant materials: A comprehensive review.Trends Food Sci. Technol.202111241943010.1016/j.tifs.2021.04.015
     [Google Scholar]
  3. TanJ. HanY. HanB. QiX. CaiX. GeS. XueH. Extraction and purification of anthocyanins: A review.J. Agricul. Food Res.2022810030610031310.1016/j.jafr.2022.100306
     [Google Scholar]
  4. AliZ. SaleemM. AttaB.M. KhanS.S. HammadG. Determination of curcuminoid content in turmeric using fluorescence spectroscopy.Spectrochim. Acta A Mol. Biomol. Spectrosc.201921319219810.1016/j.saa.2019.01.02830685558
     [Google Scholar]
  5. Luque de CastroM.D. Priego-CapoteF. Soxhlet extraction: Past and present panacea.J. Chromatogr. A20101217162383238910.1016/j.chroma.2009.11.02719945707
     [Google Scholar]
  6. AhsanR. ArshadM. KhushtarM. AhmadM.A. MuazzamM. AkhterM.S. GuptaG. MuzahidM. A comprehensive review on physiological effects of curcumin.Drug Res.2020701044144710.1055/a‑1207‑946932746480
     [Google Scholar]
  7. ManasaP.S.L. KambleA.D. ChilakamarthiU. Various extraction techniques of curcumin: A comprehensive review.ACS Omega2023838348683487810.1021/acsomega.3c0420537779951
     [Google Scholar]
  8. HorosanskaiaE. YuanL. Seidel-MorgensternA. LorenzH. Purification of curcumin from ternary extract-similar mixtures of curcuminoids in a single crystallization step.Crystals202010320622210.3390/cryst10030206
     [Google Scholar]
  9. PanY. JuR. CaoX. PeiH. ZhengT. WangW. Optimization extraction and purification of biological activity curcumin from Curcuma longa L by high-performance counter-current chromatography.J. Sep. Sci.20204381586159210.1002/jssc.20190117432027757
     [Google Scholar]
  10. BhatA. MahalakshmiA.M. RayB. TuladharS. HediyalT.A. ManthiannemE. PadamatiJ. ChandraR. ChidambaramS.B. SakharkarM.K. Benefits of curcumin in brain disorders.Biofactors201945566668910.1002/biof.153331185140
     [Google Scholar]
  11. GiordanoA. TommonaroG. Curcumin and Cancer.Nutrients201911102376239610.3390/nu1110237631590362
     [Google Scholar]
  12. PatelS.S. AcharyaA. RayR.S. AgrawalR. RaghuwanshiR. JainP. Cellular and molecular mechanisms of curcumin in prevention and treatment of disease.Crit. Rev. Food Sci. Nutr.202060688793910.1080/10408398.2018.155224430632782
     [Google Scholar]
  13. VollonoL. FalconiM. GazianoR. IacovelliF. DikaE. TerraccianoC. BianchiL. CampioneE. Potential of curcumin in skin disorders.Nutrients20191192169219410.3390/nu1109216931509968
     [Google Scholar]
  14. BurgeK. GunasekaranA. EckertJ. ChaabanH. Curcumin and intestinal inflammatory diseases: Molecular mechanisms of protection.Int. J. Mol. Sci.20192081912194810.3390/ijms2008191231003422
     [Google Scholar]
  15. WangQ. YeC. SunS. LiR. ShiX. WangS. ZengX. KuangN. LiuY. ShiQ. LiuR. Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects.Int. Immunopharmacol.20197229230010.1016/j.intimp.2019.04.02731005039
     [Google Scholar]
  16. ChittasuphoC. ManthaisongA. OkonogiS. TadtongS. SameeW. Effects of quercetin and curcumin combination on antibacterial, antioxidant, in vitro wound healing and migration of human dermal fibroblast cells.Int. J. Mol. Sci.202123114215810.3390/ijms2301014235008566
     [Google Scholar]
  17. HussainZ. ThuH.E. AmjadM.W. HussainF. AhmedT.A. KhanS. Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives.Mater. Sci. Eng. C2017771316132610.1016/j.msec.2017.03.22628532009
     [Google Scholar]
  18. RathoreS. MukimM. SharmaP. DeviS. NagarJ.C. KhalidM. Curcumin: A review for health benefits.Int. J. Res. Rev.202071273290
     [Google Scholar]
  19. MansouriK. RasoulpoorS. DaneshkhahA. AbolfathiS. SalariN. MohammadiM. RasoulpoorS. ShabaniS. Clinical effects of curcumin in enhancing cancer therapy: A systematic review.BMC Cancer202020179110.1186/s12885‑020‑07256‑832838749
     [Google Scholar]
  20. TomehM.A. HadianamreiR. ZhaoX. A review of curcumin and its derivatives as anticancer agents.Int. J. Mol. Sci.2019205103310.3390/ijms2005103330818786
     [Google Scholar]
  21. LiL. ZhangX. PiC. YangH. ZhengX. ZhaoL. WeiY. Review of curcumin physicochemical targeting delivery system.Int. J. Nanomedicine2020159799982110.2147/IJN.S27620133324053
     [Google Scholar]
  22. NoorafshanA. Ashkani-EsfahaniS. A review of therapeutic effects of curcumin.Curr. Pharm. Des.201319112032204623116311
     [Google Scholar]
  23. HewlingsS. KalmanD. Curcumin: A review of its effects on human health.Foods20176109210.3390/foods610009229065496
     [Google Scholar]
  24. Pulido-MoranM. Moreno-FernandezJ. Ramirez-TortosaC. Ramirez-TortosaM.C. Curcumin and Health.Molecules201621326410.3390/molecules2103026426927041
     [Google Scholar]
  25. LanX. LiuY. WangL. WangH. HuZ. DongH. YuZ. YuanY. A review of curcumin in food preservation: Delivery system and photosensitization.Food Chem.202342413646410.1016/j.foodchem.2023.13646437247602
     [Google Scholar]
  26. AydinF. YilmazE. SoylakM. Vortex assisted deep eutectic solvent (DES)-emulsification liquid-liquid microextraction of trace curcumin in food and herbal tea samples.Food Chem.201824344244710.1016/j.foodchem.2017.09.15429146363
     [Google Scholar]
  27. Shaker ShiranH. BaghbanbashiM. Ghazizadeh AhsaieF. PazukiG. Study of curcumin partitioning in polymer-salt aqueous two phase systems.J. Mol. Liq.202030311262911263810.1016/j.molliq.2020.112629
     [Google Scholar]
  28. NabatiM. MahkamM. HeidariH. Isolation and characterization of curcumin from powdered rhizomes of turmeric plant marketed in Maragheh city of Iran with Soxhlet technique.Iran. Chem. Commun.201424236243
     [Google Scholar]
  29. DuttaB. Study of secondary metabolite constituents. and curcumin contents of six different species of genus Curcuma.J. Med. Plants Stud.201535116119
     [Google Scholar]
  30. FarzanehV. CarvalhoI.S. Modelling of microwave. Assisted extraction (MAE) of anthocyanins (TMA).J. Appl. Res. Med. Aromat. Plan.201769210010.1016/j.jarmap.2017.02.005
     [Google Scholar]
  31. LiangH. WangW. XuJ. ZhangQ. ShenZ. ZengZ. LiQ. Optimization of ionic liquid-based microwave-assisted extraction technique for curcuminoids from Curcuma longa L.Food Bioprod. Process.2017104576510.1016/j.fbp.2017.04.003
     [Google Scholar]
  32. RodsamaiT. ChaijanM. NisoaM. DonlaoN. RawdkuenS. ChunglokW. CheongL.Z. PanpipatW. Improved curcumin recovery and in vitro biological activity of turmeric extracts using nipa palm syrup– and nipa palm vinegar–based natural deep eutectic solvent (NADES) hybridized with microwave-assisted extraction.Food Bioproce. Technol.20241772009202210.1007/s11947‑023‑03253‑4
     [Google Scholar]
  33. RosarinaD. NarawangsaD.R. ChandraN.S.R. SariE. HermansyahH. Optimization of ultrasonic—assisted extraction (UAE) method using natural deep eutectic solvent (NADES) to increase curcuminoid yield from Curcuma longa L., Curcuma xanthorrhiza, and Curcuma mangga Val.Molecules202227186080609210.3390/molecules2718608036144813
     [Google Scholar]
  34. ShirsathS.R. SableS.S. GaikwadS.G. GogateP.R. Ultrasound assisted curcumin recovery from Curcuma aromatica: Understanding the effect of different operating parameters.Chem. Eng. Process.202116910860410861410.1016/j.cep.2021.108604
     [Google Scholar]
  35. InsuanW. HansupalakN. ChahomchuenT. Extraction of curcumin from turmeric by ultrasonic-assisted extraction, identification, and evaluation of the biological activity.J. Herb. Pharm.202211218819610.34172/jhp.2022.23
     [Google Scholar]
  36. GligorO. MocanA. MoldovanC. LocatelliM. CrișanG. FerreiraI.C.F.R. Enzyme-assisted extractions of polyphenols: A comprehensive review.Trends Food Sci. Technol.20198830231510.1016/j.tifs.2019.03.029
     [Google Scholar]
  37. KurmudleN. KagliwalL.D. BankarS.B. SinghalR.S. Enzyme-assisted extraction for enhanced yields of turmeric oleoresin and its constituents.Food Biosci.201333364110.1016/j.fbio.2013.06.001
     [Google Scholar]
  38. SahneF. MohammadiM. NajafpourG.D. MoghadamniaA.A. Enzyme-assisted ionic liquid extraction of bioactive compound from turmeric (Curcuma longa L.): Isolation, purification and analysis of curcumin.Ind. Crops Prod.20179568669410.1016/j.indcrop.2016.11.037
     [Google Scholar]
  39. SharmaA. RayA. SinghalR.S. Co-extraction of turmeric (Curcuma longa L.) and dried coconut shreds by supercritical fluid extraction (SFE): Chemical and bioactivity profile.J. Clean. Prod.2023382113531310.1016/j.jclepro.2022.135313
     [Google Scholar]
  40. Osorio-TobónJ.F. CarvalhoP.I.N. RostagnoM.A. MeirelesM.A.A. Process integration for turmeric products extraction using supercritical fluids and pressurized liquids: Economic evaluation.Food Bioprod. Process.20169822723510.1016/j.fbp.2016.02.001
     [Google Scholar]
  41. Martinez-CorreaH.A. PaulaJ.T. KayanoA.C.A.V. QueirogaC.L. MagalhãesP.M. CostaF.T.M. CabralF.A. Composition and antimalarial activity of extracts of Curcuma longa L. obtained by a combination of extraction processes using supercritical CO2, ethanol and water as solvents.J. Supercrit. Fluids201711912212910.1016/j.supflu.2016.08.017
     [Google Scholar]
  42. ChhoukK. WahyudionoW. KandaH. GotoM. Comparison of conventional and ultrasound assisted supercritical carbon dioxide extraction of curcumin from turmeric (Curcuma longa L.).Eng. J.20172155365
     [Google Scholar]
  43. LoarceL. Oliver-SimancasR. MarchanteL. Díaz-MarotoM.C. AlañónM.E. Implementation of subcritical water extraction with natural deep eutectic solvents for sustainable extraction of phenolic compounds from winemaking by-products.Food Res. Int.202013710972810.1016/j.foodres.2020.10972833233297
     [Google Scholar]
  44. ToddR. BaroutianS. A techno-economic comparison of subcritical water, supercritical CO2 and organic solvent extraction of bioactives from grape marc.J. Clean. Prod.201715834935810.1016/j.jclepro.2017.05.043
     [Google Scholar]
  45. Valizadeh KiamahallehM. Najafpour-DarziG. RahimnejadM. MoghadamniaA.A. Valizadeh KiamahallehM. High performance curcumin subcritical water extraction from turmeric (Curcuma longa L.).J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.2016102219119810.1016/j.jchromb.2016.04.02127107245
     [Google Scholar]
  46. RezaeiF. EikaniM.H. NosratiniaF. BidaroniH.H. Optimization of ethanol-modified subcritical water extraction of curcuminoids from turmeric (Curcuma longa L.) rhizomes: Comparison with conventional techniques.Food Chem.202341013533110.1016/j.foodchem.2022.13533136610095
     [Google Scholar]
  47. DegotP. HuberV. TouraudD. KunzW. Curcumin extracts from Curcuma Longa – Improvement of concentration, purity, and stability in food-approved and water-soluble surfactant-free microemulsions.Food Chem.2021339112814012814710.1016/j.foodchem.2020.12814033152894
     [Google Scholar]
  48. DhingraD. BishtM. BhawnaB. PandeyS. Enhanced solubility and improved stability of curcumin in novel water-in-deep eutectic solvent microemulsions.J. Mol. Liq.202133911703711704110.1016/j.molliq.2021.117037
     [Google Scholar]
  49. Taghavi KevijH. MohammadianM. SalamiM. Complexation of curcumin with whey protein isolate for enhancing its aqueous solubility through a solvent-free pH-driven approach.J. Food Process. Preserv.20194312e14227e1423510.1111/jfpp.14227
     [Google Scholar]
  50. NampoothiriS.V. PraseethaE.K. VenugopalanV.V. Nirmala MenonA. Process development for the enrichment of curcuminoids in turmeric spent oleoresin and its inhibitory potential against LDL oxidation and angiotensin- converting enzyme.Int. J. Food Sci. Nutr.201263669670210.3109/09637486.2011.65294122263555
     [Google Scholar]
  51. TsengJ.D. LeeH.L. YehK.L. LeeT. Recyclable positive azeotropes for the purification of curcumin with optimum purity and solvent capacity.Chem. Eng. Res. Des.202218020021110.1016/j.cherd.2022.02.019
     [Google Scholar]
  52. ZhangQ.W. LinL.G. YeW.C. Techniques for extraction and isolation of natural products: A comprehensive review.Chin. Med.20181312010.1186/s13020‑018‑0177‑x29692864
     [Google Scholar]
  53. WangL. HuJ. LvW. LuW. PeiD. LvY. WangW. ZhangM. DingR. LvM. Optimized extraction of astaxanthin from shrimp shells treated by biological enzyme and its separation and purification using macroporous resin.Food Chem.20213633013036913037610.1016/j.foodchem.2021.13036934274882
     [Google Scholar]
  54. ChenC. JinS. XiangX. WangX. ShiQ. YangM. JiS. HuangR. SongC. Enrichment and cytotoxic activity of curcuminoids from turmeric using macroporous resins.J. Food Sci.20178292024203010.1111/1750‑3841.1380028837227
     [Google Scholar]
  55. AhmedM. AhmadS. IrfanM. A green ultra-fast liquid chromatographic method for quantification of curcumin in extract of Curcuma longa L. followed by confirmation via spectroscopic techniques.Separ. Sci. Plus20214311812710.1002/sscp.202000063
     [Google Scholar]
  56. AkterJ. IslamM.Z. HossainM.A. TakaraK. Anti-tyrosinase properties of different species of turmeric and isolation of active compounds from Curcuma amada.Med. Chem. Res.20213091669167610.1007/s00044‑021‑02764‑z
     [Google Scholar]
  57. LiL. ZhaoJ. YangT. SunB. High-speed countercurrent chromatography as an efficient technique for large separation of plant polyphenols: A review.Food Res. Int.202215311095610.1016/j.foodres.2022.11095635227478
     [Google Scholar]
  58. LinT. XuP. ChenB. FangL. YouH. TongS. Solvent strength of aqueous phase for two typical biphasic solvent systems in high-speed countercurrent chromatography.J. Chromatogr. A2022166346276746277410.1016/j.chroma.2021.46276734971862
     [Google Scholar]
  59. PanZ.H. NingD.S. FuY.X. LiD.P. ZouZ.Q. XieY.C. YuL.L. LiL.C. Preparative isolation of piceatannol derivatives from passion fruit (Passiflora edulis) seeds by high-speed countercurrent chromatography combined with high-performance liquid chromatography and screening for α-glucosidase inhibitory activities.J. Agric. Food Chem.20206861555156210.1021/acs.jafc.9b0487131986026
     [Google Scholar]
  60. LiL. YuY. LuD. ChenJ. GuoJ. LiangJ. ZhangA. YangZ. Bioassay-guided separation and identification of the anticancer composition from Curcuma longa L. by the combination strategy of methanol gradient countercurrent chromatography and ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry.J. Sep. Sci.202245244478449010.1002/jssc.20220034836239144
     [Google Scholar]
  61. Si-HungL. BambaT. Current state and future perspectives of supercritical fluid chromatography.Trends Analyt. Chem.202214911655011655410.1016/j.trac.2022.116550
     [Google Scholar]
  62. WestC. Recent trends in chiral supercritical fluid chromatography.Trends Analyt. Chem.201912011564811565610.1016/j.trac.2019.115648
     [Google Scholar]
  63. KaplitzA.S. BergerT.A. BergerB.K. SchugK.A. A review of fraction collection technology for supercritical fluid chromatography.Trends Analyt. Chem.202215111658810.1016/j.trac.2022.116588
     [Google Scholar]
  64. SongW. QiaoX. LiangW. JiS. YangL. WangY. XuY. YangY. GuoD. YeM. Efficient separation of curcumin, demethoxycurcumin, and bisdemethoxycurcumin from turmeric using supercritical fluid chromatography: From analytical to preparative scale.J. Sep. Sci.201538193450345310.1002/jssc.20150068626256681
     [Google Scholar]
  65. PurushothamanA. RoseK.T. JacobJ.M. VaratharajR. ShashikalaK. JanardananD. Curcumin analogues with improved antioxidant properties: A theoretical exploration.Food Chem.2022373Part B13149910.1016/j.foodchem.2021.13149934763936
     [Google Scholar]
  66. JakubczykK. DrużgaA. KatarzynaJ. Skonieczna-ŻydeckaK. Antioxidant potential of curcumin: A meta-analysis of randomized clinical trials.Antioxidants2020911109210.3390/antiox911109233172016
     [Google Scholar]
  67. LlanoS. GómezS. LondoñoJ. RestrepoA. Antioxidant activity of curcuminoids.Phys. Chem. Chem. Phys.20192173752376010.1039/C8CP06708B30702098
     [Google Scholar]
  68. ZhouY. ZhangJ. TangR.C. ZhangJ. Simultaneous dyeing and functionalization of silk with three natural yellow dyes.Ind. Crops Prod.20156422423210.1016/j.indcrop.2014.09.041
     [Google Scholar]
  69. ZhouY. TangR.C. Modification of curcumin with a reactive UV absorber and its dyeing and functional properties for silk.Dyes Pigments201613420321110.1016/j.dyepig.2016.07.016
     [Google Scholar]
  70. ZhaoP. FangJ. ZhaoY. WangY. ChenX. CaoH. Color matching and functional modification of silk by curcuminoids and luteolin.Yinran20243242810.3969/j.yinran.202403006
     [Google Scholar]
  71. GuY. PaisG. BeckerV. KörbelC. AmpofoE. EbertE. HohneckJ. LudwigN. MeeseE. BohleR.M. ZhaoY. MengerM.D. LaschkeM.W. Suppression of endothelial miR-22 mediates non-small cell lung cancer cell-induced angiogenesis.Mol. Ther. Nucleic Acids20212684986410.1016/j.omtn.2021.10.00334729252
     [Google Scholar]
  72. SunX. LiY. LinY. MeiY. LinL. HoK.T. HuangK. ZhanJ. ChenC. ZengJ. WuD. LiJ. LiuJ. LiG. MiR-22-3p modulated the antioxidant activity of curcumin via targeting the cardiolipin synthase gene CRLS1 in LO2 cells.J. Funct. Foods202310410554110.1016/j.jff.2023.105541
     [Google Scholar]
  73. SilverL.L. Challenges of antibacterial discovery.Clin. Microbiol. Rev.20112417110910.1128/CMR.00030‑1021233508
     [Google Scholar]
  74. ZhouY. ChenX. ChenT. ChenX. A review of the antibacterial activity and mechanisms of plant polysaccharides.Trends Food Sci. Technol.202212326428010.1016/j.tifs.2022.03.020
     [Google Scholar]
  75. DaiC. LinJ. LiH. ShenZ. WangY. VelkovT. ShenJ. The natural product curcumin as an antibacterial agent: Current achievements and problems.Antioxidants202211345910.3390/antiox1103045935326110
     [Google Scholar]
  76. ZhengD. HuangC. HuangH. ZhaoY. KhanM.R.U. ZhaoH. HuangL. Antibacterial mechanism of curcumin: A review.Chem. Biodivers.2020178e200017110.1002/cbdv.20200017132533635
     [Google Scholar]
  77. ChenC. ChenL. MaoC. JinL. WuS. ZhengY. CuiZ. LiZ. ZhangY. ZhuS. JiangH. LiuX. Natural extracts for antibacterial applications.Small2024209230655310.1002/smll.20230655337847896
     [Google Scholar]
  78. LiuZ. SmartJ.D. PannalaA.S. Recent developments in formulation design for improving oral bioavailability of curcumin: A review.J. Drug Deliv. Sci. Technol.20206010208210.1016/j.jddst.2020.102082
     [Google Scholar]
  79. ObeidM.A. AlsaadiM. AljabaliA.A. Recent updates in curcumin delivery.J. Liposome Res.2023331536410.1080/08982104.2022.208656735699160
     [Google Scholar]
  80. JamwalR. Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers.J. Integr. Med.201816636737410.1016/j.joim.2018.07.00130006023
     [Google Scholar]
  81. TabanelliR. BrogiS. CalderoneV. Improving curcumin bioavailability: Current strategies and future perspectives.Pharmaceutics20211310171510.3390/pharmaceutics1310171534684008
     [Google Scholar]
  82. StohsS.J. JiJ. BucciL.R. PreussH.G. A comparative pharmacokinetic assessment of a novel highly bioavailable curcumin formulation with 95% curcumin: a randomized, double-blind, crossover study.J. Am. Coll. Nutr.2018371515910.1080/07315724.2017.135811829043927
     [Google Scholar]
  83. ModasiyaM.K. PatelV.M. Studies on solubility of curcumin.Int. J. Pharm. Life Sci.2012314901497
     [Google Scholar]
  84. HuangF. GaoY. ZhangY. ChengT. OuH. YangL. LiuJ. ShiL. LiuJ. Silver-decorated polymeric micelles combined with curcumin for enhanced antibacterial activity.ACS Appl. Mater. Interfaces2017920168801688910.1021/acsami.7b0334728481077
     [Google Scholar]
  85. ParsanaN. UkaniH. ChauhanD.S. El SeoudO. MehraS. KumarA. RajeN. MalekN. Biocompatible, injectable and self-healable MOF-based anti-freezing eutectogels for higher encapsulation and sustained release of the anticancer drug curcumin.RSC Pharmaceutics20241231733210.1039/D3PM00088E
     [Google Scholar]
  86. WangM. YiN. FangK. ZhaoZ. XieR. ChenW. Deep colorful antibacterial wool fabrics by high-efficiency pad dyeing with insoluble curcumin.Chem. Eng. J.202345213912113912510.1016/j.cej.2022.139121
     [Google Scholar]
  87. ShimizuK. FunamotoM. SunagawaY. ShimizuS. KatanasakaY. MiyazakiY. WadaH. HasegawaK. MorimotoT. Anti-inflammatory action of curcumin and its use in the treatment of lifestyle-related diseases.Eur. Cardiol.201914211712210.15420/ecr.2019.17.231360234
     [Google Scholar]
  88. BenameurT. Frota GabanS.V. GiacomucciG. FilanninoF.M. TrottaT. PolitoR. MessinaG. PorroC. PanaroM.A. The effects of curcumin on inflammasome: Latest update.Molecules202328274276010.3390/molecules2802074236677800
     [Google Scholar]
  89. HasanzadehS. ReadM.I. BlandA.R. MajeedM. JamialahmadiT. SahebkarA. Curcumin: An inflammasome silencer.Pharmacol. Res.202015910492110.1016/j.phrs.2020.10492132464325
     [Google Scholar]
  90. SneharaniA.H. Curcumin–sunflower protein nanoparticles: A potential antiinflammatory agent.J. Food Biochem.2019438e12909e1291610.1111/jfbc.1290931368579
     [Google Scholar]
  91. LiG. DuanL. YangF. YangL. DengY. YuY. XuY. ZhangY. Curcumin suppress inflammatory response in traumatic brain injury via p38/ MAPK signaling pathway.Phytother. Res.20223631326133710.1002/ptr.739135080289
     [Google Scholar]
  92. ChenJ. WangZ. ZhengZ. ChenY. KhorS. ShiK. HeZ. WangQ. ZhaoY. ZhangH. LiX. LiJ. YinJ. WangX. XiaoJ. Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury.Cell Death Dis.2017810e3090e309010.1038/cddis.2017.49028981091
     [Google Scholar]
  93. GaoF. LeiJ. ZhangZ. YangY. YouH. Curcumin alleviates LPS-induced inflammation and oxidative stress in mouse microglial BV2 cells by targeting miR-137-3p/NeuroD1.RSC Advances2019966383973840610.1039/C9RA07266G35540218
     [Google Scholar]
  94. ZhangM. ZhangX. TianT. ZhangQ. WenY. ZhuJ. XiaoD. CuiW. LinY. Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis.Bioact. Mater.2022836838010.1016/j.bioactmat.2021.06.00334541407
     [Google Scholar]
  95. CaiX. HeY. CaiL. ZhanJ. LiQ. ZhongS. HouH. WangW. QiuX. An injectable elastic hydrogel crosslinked with curcumin–gelatin nanoparticles as a multifunctional dressing for the rapid repair of bacterially infected wounds.Biomater. Sci.20231193227324010.1039/D2BM02126A36935633
     [Google Scholar]
  96. OglahM.K. MustafaY.F. BashirM.K. JasimM.H. MustafaY.F. Curcumin and its derivatives: A review of their biological activities.Syst. Rev. Pharm.2020113472481
     [Google Scholar]
  97. TanA.C. AshleyD.M. LópezG.Y. MalinzakM. FriedmanH.S. KhasrawM. Management of glioblastoma: State of the art and future directions.CA Cancer J. Clin.202070429931210.3322/caac.2161332478924
     [Google Scholar]
  98. WalkerB.C. MittalS. Antitumor activity of curcumin in glioblastoma.Int. J. Mol. Sci.20202124943510.3390/ijms2124943533322413
     [Google Scholar]
  99. WongS.C. KamarudinM.N.A. NaiduR. Anticancer. mechanism of curcumin on human glioblastoma.Nutrients202113395096910.3390/nu1303095033809462
     [Google Scholar]
  100. TanX. KimG. LeeD. OhJ. KimM. PiaoC. LeeJ. LeeM.S. JeongJ.H. LeeM. A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model.Biomater. Sci.20186240741710.1039/C7BM01088E29340361
     [Google Scholar]
  101. LinX. WangL. ZhaoL. ZhuZ. ChenT. ChenS. TaoY. ZengT. ZhongY. SunH. WangZ. ZhengW. ZhangY. WuW. NanK. ChenT. Curcumin micelles suppress gastric tumor cell growth by upregulating ROS generation, disrupting redox equilibrium and affecting mitochondrial bioenergetics.Food Funct.20201154146415910.1039/D0FO00260G32347864
     [Google Scholar]
  102. XiangL. HeB. LiuQ. HuD. LiaoW. LiR. PengX. WangQ. ZhaoG. Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT-116 cells.Oncol. Rep.20204451997200810.3892/or.2020.776533000266
     [Google Scholar]
/content/journals/cmc/10.2174/0109298673353286241219061902
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Recent Progress in Curcumin: Extraction, Purification, and Bioactivity
Curr. Med. Chem. 33, 906 (2026); https://doi.org/10.2174/0109298673353286241219061902
/content/journals/cmc/10.2174/0109298673353286241219061902
/content/journals/cmc/10.2174/0109298673353286241219061902
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  • Article Type:     Review Article
Keyword(s): antioxidant; Bioactivity; curcumin; dyeing; extraction; purification

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