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2000
Volume 32, Issue 37
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Introduction

A new series of triazoles with antifungal activity have been synthesized in a one-step fashion by direct reaction of 2-(2,4-difluorophenyl)-2,3-epoxy-1-(1-1,2,4-triazol-1-yl)propane with various diamines.

Methods

Obtained compounds were profiled for biological activity against pathogenic strains of fungi and . Molecular modeling was used to predict binding modes.

Results

The lead compound was 4 times more active against than fluconazole and demonstrated a wider spectrum of activity, inhibiting the growth of .

Conclusion

The results presented herein can contribute to the development of novel antifungal therapeutic agents.

© 2025 Bentham Science Publishers
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2025-04-30
2025-11-01

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Azole Homodimers as Promising Antifungal Agents: Synthesis, Biological Activity Evaluation and Molecular Modeling
Curr. Med. Chem. 32, 8479 (2025); https://doi.org/10.2174/0109298673351661241219053546
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  • Article Type:     Research Article
Keyword(s): Antifungals; azoles; diamines; homodimers; itraconazole; ketoconazole

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