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2000
Volume 33, Issue 7
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X
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Abstract

Mitochondria-associated membranes (MAMs) are pivotal in cellular homeostasis, mediating communication between the endoplasmic reticulum and mitochondria. They are increasingly recognized for their role in atherosclerosis and coronary artery disease (CAD). This review delves into the cellular perspective of MAMs' impact on atherosclerosis and CAD, highlighting their influence on disease progression and the potential for therapeutic intervention. MAMs are implicated in key pathophysiological processes such as the generation of reactive oxygen species, calcium homeostasis, myocardial ischemia-reperfusion injury, autophagy, lipid synthesis and transport, and energy metabolism—fundamental to the development and progression of atherosclerosis and CAD. The complex interplay of MAMs with these pathological processes underscores their potential as therapeutic targets. This review synthesizes current understanding and emphasizes the need for further research to elucidate the multifaceted roles of MAMs in atherosclerosis and CAD, offering avenues for developing novel strategies aimed at improving mitochondrial health and mitigating the impact of these conditions.

© 2026 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/cmc/10.2174/0109298673343245250128093845
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The Pathophysiological Role of Mitochondria-associated Membranes in Coronary Artery Disease and Atherosclerosis
Curr. Med. Chem. 33, 1481 (2026); https://doi.org/10.2174/0109298673343245250128093845
/content/journals/cmc/10.2174/0109298673343245250128093845
/content/journals/cmc/10.2174/0109298673343245250128093845
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  • Article Type:     Review Article
Keyword(s): atherosclerosis; autophagy; calcium homeostasis; coronary artery disease (CAD); ischemia-reperfusion injury; Mitochondria-associated membranes (MAMs); reactive oxygen species (ROS)

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