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2000
Volume 32, Issue 32
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Background

The development of effective anti-cancer medicines with low side effects is imperative as cancer continues to be a leading cause of death globally. By obstructing the survival and growth of cancer cells, small-molecule medications have made tremendous progress in the field of cancer research. Several bioactive heterocyclic compounds, including derivatives of piperidine and 2,3-dihydrobenzofuran, have shown great promise and are found in various anti-cancer medications. Cancer growth and metastasis are hindered by these small molecule inhibitors, which interfere with vital signals that drive cancer cell proliferation.

Objective

This study focuses on the synthesis and evaluation of novel Sulfonyl Piperidine Analogues containing 2,3-dihydrobenzofuran-5-carboxamide as potential anti-can cer agents.

Methods

The synthesized compounds were characterized using spectroscopic techniques such as 1H NMR and ESI-MS. Protein-drug interaction studies, DFT analysis, and target prediction techniques were employed. The anti-cancer properties of the compounds were evaluated against MCF-7 cell lines. Compounds and were specifically investigated for their growth-inhibitory effects on MCF7 breast cancer cells.

Results

Compounds and demonstrated strong binding affinity towards both mutated BRCA1 (PDB ID: 1N5O) and BRCA2 (PDB ID:8BR9). Furthermore, they displayed notable efficacy against MCF-7 cell lines.

Conclusion

Synthesized compounds displayed activity against MCF-7 cell lines, supporting findings from predictions. Further investigations are warranted to elucidate the mechanisms of action of these selected molecules against MCF-7 cell types.

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Synthesis, DFT, ADMET, and Docking Studies of Novel Sulfonyl Piperidine Analogues Containing 2,3-dihydrobenzofuran-5-carboxamide
Curr. Med. Chem. 32, 7162 (2025); https://doi.org/10.2174/0109298673329232241007101050
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  • Article Type:     Research Article
Keyword(s): 2,3-dihydrobenzofuran-5-carboxamide; antibiotics; DFT; docking; piperidine; Sulfonyl piperidine

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