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image of The Protective Effects of Ferula assa-foetida L. oleo-gum Resin on Diabetic Neuropathy in Animal Models

Abstract

Background

has traditionally been used to treat various diseases, including infections, asthma, stomach aches, and flatulence. Previous studies have highlighted its anti-inflammatory, anti-oxidative, anti-diabetic, neuroprotective, and nerve-stimulating properties.

Objective

This study aimed to evaluate the therapeutic effects and molecular mechanisms of action of the oleo-gum resin from in an animal model of diabetic neuropathy (DN).

Methods

The essential oil of oleo-gum resin from Ferula assa-foetida L. was analyzed using Gas Chromatography-Mass Spectrometric Analysis. Forty-two male Wistar rats were included in the study, with diabetes induced streptozotocin (STZ) injection. The rats were randomly assigned to seven groups (n=6 per group) and treated with different doses of extract (100, 200 mg/kg/day) or oil (10, 20 mg/kg/day), alongside appropriate control groups. After a five-week treatment period, samples of dorsal root ganglia (DRG), pancreatic tissue, and blood were collected. Key parameters assessed included blood glucose and insulin levels, motor function tests, oxidative stress protein generation, pro-inflammatory cytokine gene expression, and histopathological analyses.

Results

Treatment with various doses of extract or oil, as well as gabapentin, led to significant improvements. These included reduced blood sugar levels, increased insulin levels, and improved glycemic control. Motor function was enhanced, while the expression of pro-inflammatory cytokines and oxidative stress markers was significantly reduced.

Conclusion

These findings indicate a promising therapeutic approach for managing DN. Further studies are warranted to elucidate the underlying mechanisms of beneficial effects in DN.

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2025-03-18
2025-11-04

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The Protective Effects of Ferula assa-foetida L. oleo-gum Resin on Diabetic Neuropathy in Animal Models
Bentham Science Publishers ; https://doi.org/10.2174/0109298673327506250305043440
/content/journals/cmc/10.2174/0109298673327506250305043440
/content/journals/cmc/10.2174/0109298673327506250305043440
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  • Article Type:     Research Article
Keywords: Diabetes mellitus ; oleo-gum resin ; Ferula assa-foetida L. ; anti-oxidative ; streptozotocin ; diabetic neuropathy

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