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2000
Volume 33, Issue 7
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Cancer stands as a significant global health challenge due to its mortality rates and the complexities involved in its treatment. Addressing issues, such as metastasis, recurrence, chemoresistance, and treatment-related toxicity, remains pivotal in cancer therapy advancement. Therefore, exploration of novel therapeutic agents has emerged as a priority. As the risk of cancer continues to rise, effective measures must be taken to combat it. One promising approach is to explore natural remedies, such as terpenoids, which have demonstrated anticancer activity. Utilizing terpenoids could aid in the development of potent compounds to fight cancer. By studying the structural makeup of various terpenoid derivatives from previous research, we can identify which structural groups are essential for their anticancer activity. This understanding of the structure-activity relationship is crucial for developing new, effective anticancer agents based on terpenoids. Terpenoids, a diverse class of plant-derived secondary metabolites composed of multiple isoprene units, have garnered attention for their potential anticancer and pharmacological qualities. Some terpenoids exhibit notable anticancer effects by concentrating on several stages of cancer development. They show promise in blocking the initiation of early carcinogenesis by the induction of cell cycle arrest, the inhibition of cancer cell differentiation, and the induction of apoptosis. This study delves into the investigation of specific terpenoids showcasing promising anticancer activity against prevalent malignancies, including breast, colon, ovarian, and lung cancers. The study also explores the relationship between the structure and activity of these compounds, which sheds light on how effective they are against a variety of cancer cell types. The comprehensive discussion centres on elucidating terpenoids with substantial potential for combating diverse cancer types, offering insights into their structural features and promising anticancer mechanisms.

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References

  1. RashidH. XuY. MuhammadY. WangL. JiangJ. Research advances on anticancer activities of matrine and its derivatives: An updated overview.Eur. J. Med. Chem.201916120523810.1016/j.ejmech.2018.10.037 30359819
     [Google Scholar]
  2. SiegelR.L. MillerK.D. JemalA. Cancer statistics, 2019.CA Cancer J. Clin.201969173410.3322/caac.21551 30620402
     [Google Scholar]
  3. GibbsJ.B. Mechanism-based target identification and drug discovery in cancer research.Science200028754601969197310.1126/science.287.5460.1969
     [Google Scholar]
  4. HanahanD. WeinbergR.A. Hallmarks of cancer: The next generation.Cell2011144564667410.1016/j.cell.2011.02.013 21376230
     [Google Scholar]
  5. SungH. FerlayJ. SiegelR.L. LaversanneM. SoerjomataramI. JemalA. BrayF. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.CA Cancer J. Clin.202171320924910.3322/caac.21660 33538338
     [Google Scholar]
  6. HaiderT. PandeyV. BanjareN. GuptaP.N. SoniV. Drug resistance in cancer: Mechanisms and tackling strategies.Pharmacol. Rep.20207251125115110.1007/s43440‑020‑00138‑7 32700248
     [Google Scholar]
  7. RahmanA. Plant-based products in cancer prevention and treatment.Functional Foods in Cancer Prevention and Therapy.Cambridge, MassachusettsAcademic Press202010.1016/B978‑0‑12‑816151‑7.00013‑2
     [Google Scholar]
  8. BergmanM.E. DavisB. PhillipsM.A. Medically useful plant terpenoids: Biosynthesis, occurrence, and mechanism of action.Molecules20192421396110.3390/molecules24213961 31683764
     [Google Scholar]
  9. ElshamyA.I. NassarM.I. Xenia terpenoids as anticancer promoters.J. Biol. Active Prod. Nat.2015527810710.1080/22311866.2015.1015611
     [Google Scholar]
  10. ParsaN. Environmental factors inducing human cancers.Iran. J. Public Health2012411119 23304670
     [Google Scholar]
  11. JohnsonN. Tobacco use and oral cancer: A global perspective.J. Dent. Educ.200165432833910.1002/j.0022‑0337.2001.65.4.tb03403.x 11336118
     [Google Scholar]
  12. MillikanR.C. PlayerJ.S. deCotretA.R. TseC.K. KekuT. Polymorphisms in DNA repair genes, medical exposure to ionizing radiation, and breast cancer risk.Cancer Epidemiol. Biomarkers Prev.200514102326233410.1158/1055‑9965.EPI‑05‑0186 16214912
     [Google Scholar]
  13. BarberG.N. STING: Infection, inflammation and cancer.Nat. Rev. Immunol.2015151276077010.1038/nri3921 26603901
     [Google Scholar]
  14. Baena RuizR. Salinas HernándezP. Diet and cancer: Risk factors and epidemiological evidence.Maturitas201477320220810.1016/j.maturitas.2013.11.010 24374225
     [Google Scholar]
  15. López-OtínC. DiamandisE.P. Breast and prostate cancer: An analysis of common epidemiological, genetic, and biochemical features.Endocr. Rev.199819436539610.1210/er.19.4.365 9715372
     [Google Scholar]
  16. FellerL. KhammissaR.A.G. KramerB. AltiniM. LemmerJ. Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face.Head Face Med.20161211110.1186/s13005‑016‑0106‑0 26850723
     [Google Scholar]
  17. SchottenfeldD. Beebe-DimmerJ. Chronic inflammation: A common and important factor in the pathogenesis of neoplasia.CA Cancer J. Clin.2006562698310.3322/canjclin.56.2.69 16514135
     [Google Scholar]
  18. BarnesJ.L. ZubairM. JohnK. PoirierM.C. MartinF.L. Carcinogens and DNA damage.Biochem. Soc. Trans.20184651213122410.1042/BST20180519 30287511
     [Google Scholar]
  19. WeeP. WangZ. Epidermal growth factor receptor cell proliferation signaling pathways.Cancers2017955210.3390/cancers9050052 28513565
     [Google Scholar]
  20. HuangJ. ZhangL. WanD. ZhouL. ZhengS. LinS. QiaoY. Extracellular matrix and its therapeutic potential for cancer treatment.Signal Transduct. Target. Ther.20216115310.1038/s41392‑021‑00544‑0 33888679
     [Google Scholar]
  21. ZanniG.R. WickJ.Y. Telomeres: Unlocking the mystery of cell division and aging.Consult Pharm.2011262789010.4140/TCP.n.2011.78 21310705
     [Google Scholar]
  22. PapettiM. HermanI.M. Mechanisms of normal and tumor-derived angiogenesis.Am. J. Physiol. Cell Physiol.20022825C947C97010.1152/ajpcell.00389.2001 11940508
     [Google Scholar]
  23. GlanemannM. ShiB. LiangF. SunX.G. BahraM. JacobD. NeumannU. NeuhausP. Surgical strategies for treatment of malignant pancreatic tumors: Extended, standard or local surgery?World J. Surg. Oncol.20086112310.1186/1477‑7819‑6‑123 19014474
     [Google Scholar]
  24. GhaffariA. BahmaieB. NazariM. A mixed radiotherapy and chemotherapy model for treatment of cancer with metastasis.Math. Methods Appl. Sci.201639154603461710.1002/mma.3887
     [Google Scholar]
  25. LiuJ. ChenZ. LiY. ZhaoW. WuJ. ZhangZ. PD-1/PD-L1 checkpoint inhibitors in tumor immunotherapy.Front. Pharmacol.20211273179810.3389/fphar.2021.731798 34539412
     [Google Scholar]
  26. PalomerasS. Ruiz-MartínezS. PuigT. Targeting breast cancer stem cells to overcome treatment resistance.Molecules2018239219310.3390/molecules23092193 30200262
     [Google Scholar]
  27. NewmanD.J. CraggG.M. Natural products as sources of new drugs over the last 25 years.J. Nat. Prod.200770346147710.1021/np068054v 17309302
     [Google Scholar]
  28. KuttanG. PratheeshkumarP. ManuK.A. KuttanR. Inhibition of tumor progression by naturally occurring terpenoids.Pharm. Biol.20114910995100710.3109/13880209.2011.559476 21936626
     [Google Scholar]
  29. GershenzonJ. DudarevaN. The function of terpene natural products in the natural world.Nat. Chem. Biol.20073740841410.1038/nchembio.2007.5 17576428
     [Google Scholar]
  30. GasmiA. Gasmi BenahmedA. ShanaidaM. ChirumboloS. MenzelA. AnzarW. ArshadM. Cruz-MartinsN. LysiukR. BeleyN. OliinykP. ShanaidaV. DenysA. PeanaM. BjørklundG. Anticancer activity of broccoli, its organosulfur and polyphenolic compounds.Crit. Rev. Food Sci. Nutr.20231911910.1080/10408398.2023.2195493 37129118
     [Google Scholar]
  31. EvidenteA. Advances on anticancer fungal metabolites: Sources, chemical and biological activities in the last decade (2012–2023).Nat. Prod. Bioprospect.20241413110.1007/s13659‑024‑00452‑0 38743184
     [Google Scholar]
  32. ConnollyJ.D. HillR.A. Dictionary of Terpenoids.Boston, MASpringer US199110.1007/978‑1‑4899‑4513‑6
     [Google Scholar]
  33. ChengA.X. LouY.G. MaoY.B. LuS. WangL.J. ChenX.Y. Plant terpenoids: Biosynthesis and ecological functions.J. Integr. Plant Biol.200749217918610.1111/j.1744‑7909.2007.00395.x
     [Google Scholar]
  34. KłosP. ChlubekD. Plant-derived terpenoids: A promising tool in the fight against melanoma.Cancers202214350210.3390/cancers14030502 35158770
     [Google Scholar]
  35. KamranS. SinniahA. AbdulghaniM.A.M. AlshawshM.A. Therapeutic potential of certain terpenoids as anticancer agents: A scoping review.Cancers2022145110010.3390/cancers14051100 35267408
     [Google Scholar]
  36. YangW. ChenX. LiY. GuoS. WangZ. YuX. Advances in pharmacological activities of terpenoids.Nat. Prod. Commun.20201531934578X2090355.10.1177/1934578X20903555
     [Google Scholar]
  37. ChristiansonD.W. Structural and chemical biology of terpenoid cyclases.Chem. Rev.201711717115701164810.1021/acs.chemrev.7b00287 28841019
     [Google Scholar]
  38. MouhidL Corzo-MartinezM TorresC VazquezL RegleroG FornariT Ramírez de MolinaA. Improving in vivo efficacy of bioactive molecules: An overview of potentially antitumor phytochemicals and currently available lipid-based delivery systems.J. Oncol.201720177351976
     [Google Scholar]
  39. AnsariI.A. AkhtarM.S. Current Insights on the role of terpenoids as anticancer agents: A perspective on cancer prevention and treatment.Natural Bio-active Compounds.SingaporeSpringer Singapore2019538010.1007/978‑981‑13‑7205‑6_3
     [Google Scholar]
  40. SharmaS.H. ThulasingamS. NagarajanS. Terpenoids as anti-colon cancer agents – A comprehensive review on its mechanistic perspectives.Eur. J. Pharmacol.201779516917810.1016/j.ejphar.2016.12.008 27940056
     [Google Scholar]
  41. El-BabaC. BaassiriA. KiriakoG. DiaB. FadlallahS. MoodadS. DarwicheN. Terpenoids’ anti-cancer effects: Focus on autophagy.Apoptosis2021269-1049151110.1007/s10495‑021‑01684‑y 34269920
     [Google Scholar]
  42. MullauerF.B. KesslerJ.H. MedemaJ.P. Betulinic acid, a natural compound with potent anticancer effects.Anticancer Drugs201021321522710.1097/CAD.0b013e3283357c62 20075711
     [Google Scholar]
  43. BishayeeA. AhmedS. BrankovN. PerloffM. Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer.Front. Biosci.201116198099610.2741/3730 21196213
     [Google Scholar]
  44. PatlollaJ.M.R. RaoC.V. Triterpenoids for cancer prevention and treatment: Current status and future prospects.Curr. Pharm. Biotechnol.201213114715510.2174/138920112798868719 21466427
     [Google Scholar]
  45. AshrafizadehM. AhmadiZ. MohammadinejadR. KaviyaniN. TavakolS. Monoterpenes modulating autophagy: A review study.Basic Clin. Pharmacol. Toxicol.2020126192010.1111/bcpt.13282 31237736
     [Google Scholar]
  46. HuangM. LuJ.J. HuangM.Q. BaoJ.L. ChenX.P. WangY.T. Terpenoids: Natural products for cancer therapy.Expert Opin. Investig. Drugs201221121801181810.1517/13543784.2012.727395 23092199
     [Google Scholar]
  47. MizushimaN. Autophagy: Process and function.Genes Dev.200721222861287310.1101/gad.1599207 18006683
     [Google Scholar]
  48. LevineB. KroemerG. Biological functions of autophagy genes: A disease perspective.Cell20191761-2114210.1016/j.cell.2018.09.048 30633901
     [Google Scholar]
  49. Mulcahy LevyJ.M. ThorburnA. Autophagy in cancer: Moving from understanding mechanism to improving therapy responses in patients.Cell Death Differ.202027384385710.1038/s41418‑019‑0474‑7 31836831
     [Google Scholar]
  50. KroemerG. MariñoG. LevineB. Autophagy and the integrated stress response.Mol. Cell201040228029310.1016/j.molcel.2010.09.023 20965422
     [Google Scholar]
  51. GuoJ.Y. XiaB. WhiteE. Autophagy-mediated tumor promotion.Cell201315561216121910.1016/j.cell.2013.11.019 24315093
     [Google Scholar]
  52. ChenW. ViljoenA.M. Geraniol — A review of a commercially important fragrance material.S. Afr. J. Bot.201076464365110.1016/j.sajb.2010.05.008
     [Google Scholar]
  53. CroteauR.B. DavisE.M. RingerK.L. WildungM.R. (−)-Menthol biosynthesis and molecular genetics.Naturwissenschaften2005921256257710.1007/s00114‑005‑0055‑0 16292524
     [Google Scholar]
  54. BalusamyS.R. PerumalsamyH. VeerappanK. HuqM.A. RajeshkumarS. LakshmiT. KimY.J. Citral induced apoptosis through modulation of key genes involved in fatty acid biosynthesis in human prostate cancer cells: In silico and in vitro study.BioMed Res. Int.2020202011510.1155/2020/6040727 32258129
     [Google Scholar]
  55. SchweenJ.H. DlugiR. HewittC.N. FosterP. Determination and accuracy of VOC-fluxes above the pine/oak forest at Castelporziano.Atmos. Environ.19973119921510.1016/S1352‑2310(97)00111‑8
     [Google Scholar]
  56. YoshidaE. KojimaM. SuzukiM. MatsudaF. ShimboK. OnukiA. NishioY. UsudaY. KondoA. IshiiJ. Increased carvone production in Escherichia coli by balancing limonene conversion enzyme expression via targeted quantification concatamer proteome analysis.Sci. Rep.20211112212610.1038/s41598‑021‑01469‑y 34764337
     [Google Scholar]
  57. IzhamM.N.M. HussinY. RahimN.F.C. AzizM.N.M. YeapS.K. RahmanH.S. MasarudinM.J. MohamadN.E. AbdullahR. AlitheenN.B. Physicochemical characterization, cytotoxic effect and toxicity evaluation of nanostructured lipid carrier loaded with eucalyptol.BMC Complement. Med. Ther.202121125410.1186/s12906‑021‑03422‑y 34620132
     [Google Scholar]
  58. SantosP.M. Sá-CorreiaI. Adaptation to β‐myrcene catabolism in Pseudomonas sp. M1: An expression proteomics analysis.Proteomics20099225101511110.1002/pmic.200900325 19798672
     [Google Scholar]
  59. LiuX. LiH. WangS. ZhangJ. LiuD. Sesquiterpene lactones of Aucklandia lappa: Pharmacology, pharmacokinetics, toxicity, and structure–activity relationship.Chin. Herb. Med.202113216717610.1016/j.chmed.2020.11.005 36117502
     [Google Scholar]
  60. AnibogwuR. JesusK.D. PradhanS. PashikantiS. MateenS. SharmaK. Extraction, isolation and characterization of bioactive compounds from Artemisia and their biological significance: A review.Molecules20212622699510.3390/molecules26226995 34834086
     [Google Scholar]
  61. GuanY.F. LiuX-J. PangX-J. LiuW-B. YuG-X. LiY-R. ZhangY-B. SongJ. ZhangS-Y. Recent progress of oridonin and its derivatives for cancer therapy and drug resistance.Med. Chem. Res.202130101795182110.1007/s00044‑021‑02779‑6
     [Google Scholar]
  62. WeaverB.A. How Taxol/paclitaxel kills cancer cells.Mol. Biol. Cell201425182677268110.1091/mbc.e14‑04‑0916 25213191
     [Google Scholar]
  63. JungM. DoG.M. ShinJ.H. HamY.M. ParkS.Y. KwonO. Acanthopanax koreanum Nakai modulates the immune response by inhibiting TLR 4-dependent cytokine production in rat model of endotoxic shock.Nutr. Res. Pract.20137646046510.4162/nrp.2013.7.6.460 24353831
     [Google Scholar]
  64. SeoE-J. DawoodM. HultA.K. OlssonM.L. EfferthT. Network pharmacology of triptolide in cancer cells: Implications for transcription factor binding.Investigational New Drugs: Novel Anti-Cancer Therapeutics and Therapies.Boston, MASpringer US202110.1007/s10637‑021‑01137‑y
     [Google Scholar]
  65. PanY. ChenL. LiR. LiuY. NanM. HouL. Tanshinone IIa induces autophagy and apoptosis via PI3K/Akt/mTOR axis in acute promyelocytic leukemia NB4 cells.Evid. Based Complement. Alternat. Med.202120211910.1155/2021/3372403 34691211
     [Google Scholar]
  66. MiladR. Genus Kalanchoe (Crassulaceae): A review of its ethnomedicinal, botanical, chemical and pharmacological properties.Eur. J. Med. Plants2014418610410.9734/EJMP/2014/5901
     [Google Scholar]
  67. WongV.K.W. ChiuP. ChungS.S.M. ChowL.M.C. ZhaoY.Z. YangB.B. KoB.C.B. Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo.Clin. Cancer Res.200511166002601110.1158/1078‑0432.CCR‑05‑0209 16115945
     [Google Scholar]
  68. LimJ.C.W. ChanT.K. NgD.S.W. SagineeduS.R. StanslasJ. WongW.S.F. Andrographolide and its analogues: Versatile bioactive molecules for combating inflammation and cancer.Clin. Exp. Pharmacol. Physiol.201239330031010.1111/j.1440‑1681.2011.05633.x 22017767
     [Google Scholar]
  69. SivasankarapillaiV.S. NairM.K.R. RahdarA. BungauS. ZahaD.C. AleyaL. TitD.M. Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera.Environ. Sci. Pollut. Res. Int.20202721260252603510.1007/s11356‑020‑09028‑0 32405942
     [Google Scholar]
  70. LiuJ. Pharmacology of oleanolic acid and ursolic acid.J. Ethnopharmacol.1995492576810.1016/0378‑8741(95)90032‑2 8847885
     [Google Scholar]
  71. ChouC.C. PanS.L. TengC.M. GuhJ.H. Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells.Eur. J. Pharm. Sci.200319540341210.1016/S0928‑0987(03)00144‑1 12907291
     [Google Scholar]
  72. GyémántN. TanakaM. MolnárP. DeliJ. MándokyL. MolnárJ. Reversal of multidrug resistance of cancer cells in vitro: Modification of drug resistance by selected carotenoids.Anticancer Res.2006261A367374 16475720
     [Google Scholar]
  73. KumariS. GoyalA. GargM. Phytochemistry and pharmacological update on tetraterpenoids.Nat. Prod. J.202111561762810.2174/2210315510999200806154609
     [Google Scholar]
  74. VasanthkumarT. HanumanthappaM. HanumanthappaS.K. Hepatoprotective effect of curcumin and capsaicin against lipopolysaccharide induced liver damage in mice.Pharmacogn. J.20179694795110.5530/pj.2017.6.148
     [Google Scholar]
  75. LiuY. WangL. JungJ.H. ZhangS. Sesterterpenoids.Nat. Prod. Rep.20072461401142910.1039/b617259h 18033586
     [Google Scholar]
  76. StrømgaardK. NakanishiK. Chemistry and biology of terpene trilactones from Ginkgo biloba.Angew. Chem. Int. Ed.200443131640165810.1002/anie.200300601 15038029
     [Google Scholar]
  77. AsakawaY. LudwiczukA. NagashimaF. Chemical constituents of bryophyta.Chemical Constituents of Bryophytes.Berlin, HeidelbergSpringer Link201310.1007/978‑3‑7091‑1084‑3_5
     [Google Scholar]
  78. University of Arizona Limonene study in women with breast cancer. NCT01046929.2017Available from: https://clinicaltrials.gov/study/NCT01046929?cond=cancer&term=limonene&rank=2
  79. Shanghai Zhongshan Hospital. The effect of dihydroartemisinin in PCOS. NCT05465135.2024Available from: https://clinicaltrials.gov/study/NCT05465135?cond=cancer&term=artemisinin&rank=5
  80. University of Pittsburgh. A pilot study of lycopene supplementation in prostatic intraepithelial neoplasia.NCT001781132015Available from: https://clinicaltrials. gov/study/NCT00178113?cond=cancer&term=lycopene&rank=2
    [Google Scholar]
  81. CrowellP.L. Monoterpenes in breast cancer chemoprevention.Breast Cancer Res. Treat.1997462-319119710.1023/A:1005939806591 9478274
     [Google Scholar]
  82. AtebaS.B. MvondoM.A. NgeuS.T. TchoumtchouaJ. AwounfackC.F. NjamenD. KrennL. Natural terpenoids against female breast cancer: A 5-year recent research.Curr. Med. Chem.201825273162321310.2174/0929867325666180214110932 29446727
     [Google Scholar]
  83. RabiT. BishayeeA. Terpenoids and breast cancer chemoprevention.Breast Cancer Res. Treat.2009115222323910.1007/s10549‑008‑0118‑y 18636327
     [Google Scholar]
  84. de Souza-FerrariJ. Silva-JúniorE.A. ValeJ.A. de Albuquerque SimõesL.A. de Moraes-JúniorM.O. DantasB.B. de AraújoD.A.M. A late-stage diversification via Heck-Matsuda arylation: Straightforward synthesis and cytotoxic/antiproliferative profiling of novel aryl-labdane-type derivatives.Bioorg. Med. Chem. Lett.20215212839310.1016/j.bmcl.2021.128393 34606997
     [Google Scholar]
  85. LaamariY. OubellaA. BimoussaA. El MansouriA.E. KetatniE.M. MentreO. Ait IttoM.Y. MorjaniH. KhouiliM. AuhmaniA. Design, hemiysnthesis, crystal structure and anticancer activity of 1, 2, 3-triazoles derivatives of totarol.Bioorg. Chem.202111510516510.1016/j.bioorg.2021.105165 34298240
     [Google Scholar]
  86. WangR. YangW. FanY. DehaenW. LiY. LiH. WangW. ZhengQ. HuaiQ. Design and synthesis of the novel oleanolic acid-cinnamic acid ester derivatives and glycyrrhetinic acid-cinnamic acid ester derivatives with cytotoxic properties.Bioorg. Chem.20198810295110.1016/j.bioorg.2019.102951 31054427
     [Google Scholar]
  87. OubellaA. Ait IttoM.Y. AuhmaniA. RiahiA. RobertA. DaranJ-C. MorjaniH. ParishC.A. EsseffarM. Diastereoselective synthesis and cytotoxic evaluation of new isoxazoles and pyrazoles with monoterpenic skeleton.J. Mol. Struct.2019119812692410.1016/j.molstruc.2019.126924
     [Google Scholar]
  88. MuL.H. YanH. WangY.N. YuT.F. LiuP. Triterpenoid saponins from Ardisia gigantifolia and mechanism on inhibiting proliferation of MDA-MB-231 cells.Biol. Pharm. Bull.201942219420010.1248/bpb.b18‑00569 30464092
     [Google Scholar]
  89. TengY.N. WangY. HsuP.L. XinG. ZhangY. Morris-NatschkeS.L. GotoM. LeeK.H. Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris.Phytomedicine201841626610.1016/j.phymed.2018.02.001 29519320
     [Google Scholar]
  90. EngstrandJ. NilssonH. StrömbergC. JonasE. FreedmanJ. Colorectal cancer liver metastases – a population-based study on incidence, management and survival.BMC Cancer20181817810.1186/s12885‑017‑3925‑x 29334918
     [Google Scholar]
  91. XieY.H. ChenY.X. FangJ.Y. Comprehensive review of targeted therapy for colorectal cancer.Signal Transduct. Target. Ther.2020512210.1038/s41392‑020‑0116‑z 32296018
     [Google Scholar]
  92. DucaG. AricuA. KuchkovaK. SecaraE. BarbaA. DragalinI. UngurN. SpenglerG. Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents.Nat. Prod. Res.201933213052305610.1080/14786419.2018.1516658 30445867
     [Google Scholar]
  93. LimaR.S. PerezC.N. da SilvaC.C. SantanaM.J. Queiroz JúniorL.H.K. BarretoS. de MoraesM.O. MartinsF.T. Structure and cytotoxic activity of terpenoid-like chalcones.Arab. J. Chem.20191283890390110.1016/j.arabjc.2016.02.013
     [Google Scholar]
  94. ValdeiraA.S.C. DarvishiE. WoldemichaelG.M. BeutlerJ.A. GustafsonK.R. SalvadorJ.A.R. Madecassic acid derivatives as potential anticancer agents: Synthesis and cytotoxic evaluation.J. Nat. Prod.20198282094210510.1021/acs.jnatprod.8b00864 31343174
     [Google Scholar]
  95. MengX.W. WeiY.Y. NongB.L. ZhaoH.J. ZhangX.X. Design, synthesis, and anticancer activity evaluation of curcumol derivatives.J. Asian Nat. Prod. Res.202224655656810.1080/10286020.2021.1947255 34236240
     [Google Scholar]
  96. CaiW. LiJ. ChenC. WuJ. LiJ. XueX. Design, synthesis, and anticancer evaluation of novel andrographolide derivatives bearing an α,β-unsaturated ketone moiety.Bioorg. Chem.202111210494110.1016/j.bioorg.2021.104941 33940445
     [Google Scholar]
  97. HamulićD. StadlerM. HeringS. PadrónJ.M. BassettR. RivasF. Loza-MejíaM.A. Dea-AyuelaM.A. González-CardeneteM.A. Synthesis and biological studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and representative analogues: SAR studies.J. Nat. Prod.201982482383110.1021/acs.jnatprod.8b00884 30840453
     [Google Scholar]
  98. YangJ. MuW.W. CaoY.X. LiuG.Y. Synthesis and biological evaluation of β-ionone oriented proapoptosis agents by enhancing the ROS generation.Bioorg. Chem.202010410427310.1016/j.bioorg.2020.104273 32956875
     [Google Scholar]
  99. Johnson-AjinwoO.R. UllahI. MbyeH. RichardsonA. HorrocksP. LiW.W. The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents.Bioorg. Med. Chem. Lett.20182871219122210.1016/j.bmcl.2018.02.051 29519737
     [Google Scholar]
  100. NiuN. QuT. XuJ. LuX. BodwellG.J. ZhaoZ. Synthesis of 5-alkynyltetrandrine derivatives and evaluation of their anticancer activity on A549 cell lines.Anticancer. Agents Med. Chem.201919121454146210.2174/1871520619666190408132249 30961510
     [Google Scholar]
  101. LiN. SongJ. LiD. Synthesis and antiproliferative activity of ester derivatives of mogrol through JAK2/STAT3 pathway.Chem. Biodivers.2022191e20210074210.1002/cbdv.202100742 34874105
     [Google Scholar]
  102. SongJ.R. LiN. LiD.P. Synthesis and anti-proliferation activity of mogrol derivatives bearing quinoline and triazole moieties.Bioorg. Med. Chem. Lett.20214212809010.1016/j.bmcl.2021.128090 33964443
     [Google Scholar]
  103. SuD. WeiR. YanZ. ZhongG. QinX. HuangS. LongJ. ZhangF. HeP. ChenZ. YanY. JiangN. TangW. Design, synthesis, and evaluation of antitumor activity of novel C‐6 sulfhydryl‐substituted and 20‐substituted derivatives of celastrol.Chem. Biol. Drug Des.2023102231633110.1111/cbdd.14247 37156601
     [Google Scholar]
  104. OubellaA. El MansouriA.E. FawziM. BimoussaA. LaamariY. AuhmaniA. MorjaniH. RobertA. RiahiA. IttoY.A.M. Thiazolidinone-linked1,2,3-triazoles with monoterpenic skeleton as new potential anticancer agents: Design, synthesis and molecular docking studies.Bioorg. Chem.202111510518410.1016/j.bioorg.2021.105184 34333421
     [Google Scholar]
  105. ShangF.F. WangJ.Y. XuQ. DengH. GuoH.Y. JinX. LiX. ShenQ.K. QuanZ.S. Design, synthesis of novel celastrol derivatives and study on their antitumor growth through HIF-1α pathway.Eur. J. Med. Chem.202122011347410.1016/j.ejmech.2021.113474 33930802
     [Google Scholar]
  106. Herrera-EspañaA.D. Us-MartínJ. Quintal-NoveloC. Mirón-LópezG. Quijano-QuiñonesR.F. Cáceres-CastilloD. Graniel-SabidoM. Moo-PucR.E. Mena-RejónG.J. Cytotoxic and antiproliferative activity of thiazole derivatives of Ochraceolide A.Nat. Prod. Res.202236184708471210.1080/14786419.2021.2001809 34747293
     [Google Scholar]
  107. ZhangN. YuZ. YangX. HuP. HeY. Synthesis of novel ring-contracted artemisinin dimers with potent anticancer activities.Eur. J. Med. Chem.201815082984010.1016/j.ejmech.2018.03.010 29597166
     [Google Scholar]
/content/journals/cmc/10.2174/0109298673315133240830055507
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Exploring the Potential of Terpenoids as a Possible Treatment for Cancer: Structure-activity Relationship and Mechanistic Studies
Curr. Med. Chem. 33, 1311 (2026); https://doi.org/10.2174/0109298673315133240830055507
/content/journals/cmc/10.2174/0109298673315133240830055507
/content/journals/cmc/10.2174/0109298673315133240830055507
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  • Article Type:     Review Article
Keyword(s): anticancer mechanisms; cancer; celastrol; olefin; structure-activity relationship; Terpenoids

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