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2000
Volume 32, Issue 33
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Background

PTK7 (Protein Tyrosine Kinase 7), a member of the receptor protein tyrosine kinase family, was originally discovered in colon cancer cells. It plays a pivotal role in numerous developmental and physiological processes, particularly in the regulation of cell polarity. Despite accumulating evidence of PTK7's significant influence on tumor development, a comprehensive pan-cancer analysis of PTK7 has yet to be conducted.

Methods

We conducted a comprehensive analysis of PTK7's expression, prognostic value, and mutational patterns across various tumor types. We further explored the correlations between PTK7 expression and tumor stemness, immune-related genes, immune scores, and immune cell infiltration.

Results

Enrichment analysis revealed PTK7's critical involvement in pan-cancer functions and processes, including the WNT pathway, Epithelial-Mesenchymal Transition (EMT), and cell polarity regulation. Additionally, we validated PTK7's expression in gastric cancer immunohistochemistry.

Conclusion

Our study indicates that PTK7 holds promise as an ideal pan-cancer biomarker due to its involvement in tumor progression and tumor immunity.

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/content/journals/cmc/10.2174/0109298673313999240816103054
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Cell Polarity-related Gene PTK7, a Potential Diagnostic Biomarker in Pan-cancer
Curr. Med. Chem. 32, 7327 (2025); https://doi.org/10.2174/0109298673313999240816103054
/content/journals/cmc/10.2174/0109298673313999240816103054
/content/journals/cmc/10.2174/0109298673313999240816103054
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  • Article Type:     Research Article
Keyword(s): immune infiltration; multi-omics; pan-cancer; prognosis; PTK7; tumor microenvironment

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