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2000
Volume 32, Issue 16
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

This review summarizes the scientific knowledge concerning the impact of vitamins, magnesium, and trace elements on various mechanisms contributing to the possible treatment and prevention of COVID-19, including its delayed consequences. A search was conducted in various databases, including PubMed, Scopus, ClinicalTrials.gov, and Web of Science. Among the main mechanisms involved in the effects of the studied micronutrients, immune-boosting, antioxidant and anti-inflammatory effects were also highlighted. The analyzed clinical trials confirmed that supplementation with higher daily doses of some micronutrients can reduce SARS-CoV-2 viral load and hospitalization time. The potential role of most known vitamins in preventing, treating COVID-19, and rehabilitating patients was considered. The most promising agents for combating COVID-19 and its consequences might be the following vitamins: vitamin D, ascorbic acid, polyunsaturated fatty acids (PUFAs), and some B complex vitamins. Inorganic elements deserving attention include magnesium and trace elements, such as zinc, selenium, copper, and iron. Some associations were found between micronutrient deficiencies and COVID-19 severity in children, adults, and older people. Patients can obtain the aforementioned micronutrients from natural food sources or as supplements/drugs in various dosage forms. The reviewed micronutrients might be considered adjunctive treatment strategies for COVID-19 patients.

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2024-05-20
2026-02-21

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/content/journals/cmc/10.2174/0109298673301578240515095227
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The Role of Vitamins, Magnesium, and Trace Elements in COVID-19 Treatment and Post-COVID-19 Rehabilitation: An Updated Overview
Curr. Med. Chem. 32, 3134 (2025); https://doi.org/10.2174/0109298673301578240515095227
/content/journals/cmc/10.2174/0109298673301578240515095227
/content/journals/cmc/10.2174/0109298673301578240515095227
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  • Article Type:     Review Article
Keyword(s): ascorbic acid; copper; COVID-19; fat-soluble vitamins; iron; magnesium; micronutrients; selenium; vitamin B complex; zinc

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