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2000
Volume 32, Issue 14
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Background

Abdominal aortic aneurysm (AAA) is a segmental, progressive, and fatal vascular disorder, and the current strategy for small AAAs is close observation alone. The purpose of this study is to summarize the available evidence to assess the effects of antibiotics on small abdominal aortic aneurysms (AAA).

Methods

We searched PubMed, EMBASE, Web of Science, and Scopus from inception to September 29, 2023, and included randomized controlled trials (RCTs) that evaluated the effects of antibiotics on small AAAs in humans. We first performed a meta-analysis to assess the effects of antibiotics on small AAAs. Afterward, network pharmacology analysis was applied to investigate the optimal drug generated from the meta-analysis results. We searched Pharmmapper and GeneCards to obtain the common potential targets of the selected drug and AAA-related targets. The protein-protein interaction network and functional enrichment analysis were performed by the STRING database, Cytoscape 3.7.2 software, and R, respectively. Docking studies were carried out for validation.

Results

We incorporated data from six RCTs involving a total of 997 patients. The results of this meta-analysis revealed that roxithromycin exhibited a modest yet statistically significant protective effect in terms of slowing down the AAA expansion rate. Furthermore, our subsequent bioinformatics analysis pinpointed , , , , and as potential therapeutic targets that could be explored for the treatment of AAA using roxithromycin.

Conclusion

In conclusion, the study indicates roxithromycin is a promising drug for treating small AAAs and supports its underlying clinical use in small AAAs.

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References

  1. WanhainenA. VerziniF. Van HerzeeleI. AllaireE. BownM. CohnertT. DickF. van HerwaardenJ. KarkosC. KoelemayM. KölbelT. LoftusI. ManiK. MelissanoG. PowellJ. SzeberinZ. de BorstG.J. ChakfeN. DebusS. HinchliffeR. KakkosS. KoncarI. KolhP. LindholtJ.S. de VegaM. VermassenF. Document reviewers BjörckM. ChengS. DalmanR. DavidovicL. DonasK. EarnshawJ. EcksteinH.H. GolledgeJ. HaulonS. MastracciT. NaylorR. RiccoJ.B. VerhagenH. Editor’s Choice – European Society for Vascular Surgery (ESVS) 2019 clinical practice guidelines on the management of abdominal aorto-iliac artery aneurysms.Eur. J. Vasc. Endovasc. Surg.201957189310.1016/j.ejvs.2018.09.02030528142
     [Google Scholar]
  2. StoeckerJ.B. WangG.J. Epidemiology of thoracoabdominal aortic aneurysms.Semin. Vasc. Surg.2021341182810.1053/j.semvascsurg.2021.02.001
     [Google Scholar]
  3. Guirguis-BlakeJ.M. BeilT.L. SengerC.A. CoppolaE.L. Primary care screening for abdominal aortic aneurysm.JAMA2019322222219223810.1001/jama.2019.1702131821436
     [Google Scholar]
  4. MollF.L. PowellJ.T. FraedrichG. VerziniF. HaulonS. WalthamM. van HerwaardenJ.A. HoltP.J.E. van KeulenJ.W. RantnerB. SchlösserF.J.V. SetacciF. RiccoJ.B. Management of abdominal aortic aneurysms clinical practice guidelines of the European society for vascular surgery.Eur. J. Vasc. Endovasc. Surg.2011411S1S5810.1016/j.ejvs.2010.09.011
     [Google Scholar]
  5. KentK.C. Clinical practice. Abdominal aortic aneurysms.N. Engl. J. Med.2014371222101210810.1056/NEJMcp140143025427112
     [Google Scholar]
  6. WanhainenA. VerziniF. Van HerzeeleI. AllaireE. BownM. CohnertT. DickF. van HerwaardenJ. KarkosC. KoelemayM. KölbelT. LoftusI. ManiK. MelissanoG. PowellJ. SzeberinZ. Esvs GuidelinesC. de BorstG.J. ChakfeN. DebusS. HinchliffeR. KakkosS. KoncarI. KolhP. LindholtJ.S. de VegaM. VermassenF. DocumentR. BjörckM. ChengS. DalmanR. DavidovicL. DonasK. EarnshawJ. EcksteinH.-H. GolledgeJ. HaulonS. MastracciT. NaylorR. RiccoJ.-B. VerhagenH. Editor's Choice - European Society for Vascular Surgery (ESVS) 2019 Clinical Practice Guidelines on the Management of Abdominal Aorto-iliac Artery Aneurysms.Eur. J. Vasc. Endovasc. Surg.2019571
     [Google Scholar]
  7. JinJ. Screening for abdominal aortic aneurysm.JAMA201932222225610.1001/jama.2019.1933831821432
     [Google Scholar]
  8. PrendesC.F. MeloR.G.E. CaldeiraD. D’OriaM. TsilimparisN. KoelemayM. Van HerzeeleI. WanhainenA. Systematic review and meta-analysis of contemporary abdominal aortic aneurysm growth rates.Eur. J. Vasc. Endovasc. Surg.2023S1078-5884(23)00802-X10.1016/j.ejvs.2023.09.03937777049
     [Google Scholar]
  9. GeorgeE.L. SmithJ.A. ColvardB. LeeJ.T. SternJ.R. Precocious rupture of abdominal aortic aneurysms below size criteria for repair: Risk factors and outcomes.Ann. Vasc. Surg.2023S0890-5096(23)00266-237247834
     [Google Scholar]
  10. MichelJ.B. Martin-VenturaJ.L. EgidoJ. SakalihasanN. TreskaV. LindholtJ. AllaireE. ThorsteinsdottirU. CockerillG. SwedenborgJ. Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans.Cardiovasc. Res.2011901182710.1093/cvr/cvq33721037321
     [Google Scholar]
  11. SattaJ. LaurilaA. PääkköP. HaukipuroK. SormunenR. ParkkilaS. JuvonenT. Chronic inflammation and elastin degradation in abdominal aortic aneurysm disease: an immunohistochemical and electron microscopic study.Eur. J. Vasc. Endovasc. Surg.199815431331910.1016/S1078‑5884(98)80034‑8
     [Google Scholar]
  12. GolledgeJ. ThanigaimaniS. PowellJ.T. TsaoP.S. Pathogenesis and management of abdominal aortic aneurysm.Eur. Heart J.202344292682269710.1093/eurheartj/ehad38637387260
     [Google Scholar]
  13. FreestoneT. TurnerR.J. CoadyA. HigmanD.J. GreenhalghR.M. PowellJ.T. Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm.Arterioscler. Thromb. Vasc. Biol.19951581145115110.1161/01.ATV.15.8.11457627708
     [Google Scholar]
  14. LongoG.M. XiongW. GreinerT.C. ZhaoY. FiottiN. BaxterB.T. Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms.J. Clin. Invest.2002110562563210.1172/JCI021533412208863
     [Google Scholar]
  15. JuvonenJ. JuvonenT. LaurilaA. AlakärppäH. LounatmaaK. SurcelH.M. LeinonenM. KairaluomaM.I. SaikkuP. Demonstration of Chlamydia pneumoniae in the walls of abdominal aortic aneurysms.J. Vasc. Surg.199725349950510.1016/S0741‑5214(97)70260‑X9081131
     [Google Scholar]
  16. PetersenE. BomanJ. WågbergF. AngquistK.A. Presence of Chlamydia pneumoniae in abdominal aortic aneurysms is not associated with increased activity of matrix metalloproteinases.Eur. J. Vasc. Endovasc. Surg.200224436536910.1053/ejvs.2002.1726
     [Google Scholar]
  17. YuM. ChenC. CaoY. QiR. Inhibitory effects of doxycycline on the onset and progression of abdominal aortic aneurysm and its related mechanisms.Eur. J. Pharmacol.201781110110910.1016/j.ejphar.2017.05.04128545777
     [Google Scholar]
  18. DoddB.R. SpenceR.A. Doxycycline inhibition of abdominal aortic aneurysm growth: A systematic review of the literature.Curr. Vasc. Pharmacol.20119447147810.2174/15701611179619728821595625
     [Google Scholar]
  19. JiaY. ZhangL. LiuZ. MaoC. MaZ. LiW. YuF. WangY. HuangY. ZhangW. ZhengJ. WangX. XuQ. ZhangJ. FengW. YunC. LiuC. SunJ. FuY. CuiQ. KongW. Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm.Cell Discov.2022812110.1038/s41421‑021‑00363‑135228523
     [Google Scholar]
  20. HøghA. VammenS. OstergaardL. JoensenJ.B. HennebergE.W. LindholtJ.S. Intermittent roxithromycin for preventing progression of small abdominal aortic aneurysms: Long-term results of a small clinical trial.Vasc. Endovascular Surg.200943545245610.1177/153857440933503719640922
     [Google Scholar]
  21. VammenS. LindholtJ.S. ØstergaardL. FastingH. HennebergE.W. Randomized double-blind controlled trial of roxithromycin for prevention of abdominal aortic aneurysm expansion.Br. J. Surg.20028881066107210.1046/j.0007‑1323.2001.01845.x11488791
     [Google Scholar]
  22. MosorinM. JuvonenJ. BiancariF. SattaJ. SurcelH.M. LeinonenM. SaikkuP. JuvonenT. Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: A randomized, double-blind, placebo-controlled pilot study.J. Vasc. Surg.200134460661010.1067/mva.2001.11789111668312
     [Google Scholar]
  23. MeijerC.A. StijnenT. WasserM.N.J.M. HammingJ.F. van BockelJ.H. LindemanJ.H.N. Doxycycline for stabilization of abdominal aortic aneurysms: A randomized trial.Ann. Intern. Med.20131591281582310.7326/0003‑4819‑159‑12‑201312170‑0000724490266
     [Google Scholar]
  24. BaxterB.T. MatsumuraJ. CurciJ.A. McBrideR. LarsonL. BlackwelderW. LamD. WijesinhaM. TerrinM. Effect of doxycycline on aneurysm growth among patients with small infrarenal abdominal aortic aneurysms.JAMA2020323202029203810.1001/jama.2020.523032453369
     [Google Scholar]
  25. GolledgeJ. MoxonJ.V. SinghT.P. BownM.J. ManiK. WanhainenA. Lack of an effective drug therapy for abdominal aortic aneurysm.J. Intern. Med.2020288162210.1111/joim.1295831278799
     [Google Scholar]
  26. YuX. WeiX. CaoS. Regarding ‘Lack of an effective drug therapy for abdominal aortic aneurysm’.J. Intern. Med.2020288115510.1111/joim.1297931603265
     [Google Scholar]
  27. ChenL. PengY. JiC. YuanM. YinQ. Network pharmacology-based analysis of the role of tacrolimus in liver transplantation.Saudi J. Biol. Sci.20212831569157510.1016/j.sjbs.2020.12.05033732042
     [Google Scholar]
  28. LiX. WeiS. NiuS. MaX. LiH. JingM. ZhaoY. Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis.Comput. Biol. Med.202214410538910.1016/j.compbiomed.2022.10538935303581
     [Google Scholar]
  29. NogalesC. MamdouhZ.M. ListM. KielC. CasasA.I. SchmidtH.H.H.W. Network pharmacology: Curing causal mechanisms instead of treating symptoms.Trends Pharmacol. Sci.202243213615010.1016/j.tips.2021.11.00434895945
     [Google Scholar]
  30. YiP. ZhangZ. HuangS. HuangJ. PengW. YangJ. Integrated meta-analysis, network pharmacology, and molecular docking to investigate the efficacy and potential pharmacological mechanism of Kai-Xin-San on Alzheimer’s disease.Pharm. Biol.202058193294310.1080/13880209.2020.181710332956608
     [Google Scholar]
  31. HuangY. WangX. YanC. LiC. ZhangL. ZhangL. LiangE. LiuT. MaoJ. Effect of metformin on nonalcoholic fatty liver based on meta-analysis and network pharmacology.Medicine202210143e3143710.1097/MD.000000000003143736316840
     [Google Scholar]
  32. ZhuY. YuJ. ZhangK. FengY. GuoK. SunL. RuanS. Network pharmacology analysis to explore the pharmacological mechanism of effective chinese medicines in treating metastatic colorectal cancer using meta-analysis approach.Am. J. Chin. Med.20214981839187010.1142/S0192415X2150087734781857
     [Google Scholar]
  33. PageM.J. McKenzieJ.E. BossuytP.M. BoutronI. HoffmannT.C. MulrowC.D. ShamseerL. TetzlaffJ.M. AklE.A. BrennanS.E. ChouR. GlanvilleJ. GrimshawJ.M. HróbjartssonA. LaluM.M. LiT. LoderE.W. Mayo-WilsonE. McDonaldS. McGuinnessL.A. StewartL.A. ThomasJ. TriccoA.C. WelchV.A. WhitingP. MoherD. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews.BMJ2021372n7110.1136/bmj.n7133782057
     [Google Scholar]
  34. HigginsJ.P.T. AltmanD.G. GøtzscheP.C. JüniP. MoherD. OxmanA.D. SavovicJ. SchulzK.F. WeeksL. SterneJ.A.C. The cochrane collaboration’s tool for assessing risk of bias in randomised trials.BMJ2011343oct18 2d592810.1136/bmj.d592822008217
     [Google Scholar]
  35. CumpstonM. LiT. PageM.J. ChandlerJ. WelchV.A. HigginsJ.P.T. ThomasJ. Updated guidance for trusted systematic reviews: A new edition of the Cochrane Handbook for Systematic Reviews of Interventions.Cochrane Libr.20191010ED00014210.1002/14651858.ED00014231643080
     [Google Scholar]
  36. LiuX. OuyangS. YuB. LiuY. HuangK. GongJ. ZhengS. LiZ. LiH. JiangH. PharmMapper server: A web server for potential drug target identification using pharmacophore mapping approach.Nucleic Acids Res201038W609W61410.1093/nar/gkq300
     [Google Scholar]
  37. WangX. PanC. GongJ. LiuX. LiH. Enhancing the enrichment of pharmacophore-based target prediction for the polypharmacological profiles of drugs.J. Chem. Inf. Model.20165661175118310.1021/acs.jcim.5b0069027187084
     [Google Scholar]
  38. WangX. ShenY. WangS. LiS. ZhangW. LiuX. LaiL. PeiJ. LiH. PharmMapper 2017 update: A web server for potential drug target identification with a comprehensive target pharmacophore database.Nucleic Acids Res.201745W1W356W36010.1093/nar/gkx37428472422
     [Google Scholar]
  39. StelzerG. RosenN. PlaschkesI. ZimmermanS. TwikM. FishilevichS. SteinT.I. NudelR. LiederI. MazorY. KaplanS. DaharyD. WarshawskyD. Guan-GolanY. KohnA. RappaportN. SafranM. LancetD. The GeneCards suite: From gene data mining to disease genome sequence analyses.Curr. Protoc. Bioinformatics2016541.30.11.30.3310.1002/cpbi.5
     [Google Scholar]
  40. ShannonP. MarkielA. OzierO. BaligaN.S. WangJ.T. RamageD. AminN. SchwikowskiB. IdekerT. Cytoscape: A software environment for integrated models of biomolecular interaction networks.Genome Res.200313112498250410.1101/gr.123930314597658
     [Google Scholar]
  41. O’BoyleN.M. BanckM. JamesC.A. MorleyC. VandermeerschT. HutchisonG.R. Open Babel: An open chemical toolbox.J. Cheminform.2011313310.1186/1758‑2946‑3‑3321982300
     [Google Scholar]
  42. GrosdidierA. ZoeteV. MichielinO. SwissDock, a protein-small molecule docking web service based on EADock DSS.Nucleic Acids Res201139W270W27710.1093/nar/gkr366
     [Google Scholar]
  43. Bitencourt-FerreiraG. de AzevedoW.F.Jr Docking with SwissDock.Methods Mol. Biol.2019205318920210.1007/978‑1‑4939‑9752‑7_1231452106
     [Google Scholar]
  44. SeeligerD. de GrootB.L. Ligand docking and binding site analysis with PyMOL and Autodock/Vina.J. Comput. Aided Mol. Des.201024541742210.1007/s10822‑010‑9352‑620401516
     [Google Scholar]
  45. KarlssonL. GnarpeJ. BergqvistD. LindbäckJ. PärssonH. The effect of azithromycin and Chlamydophilia pneumonia infection on expansion of small abdominal aortic aneurysms - A prospective randomized double-blind trial.J. Vasc. Surg.2009501232910.1016/j.jvs.2008.12.04819563951
     [Google Scholar]
  46. SaikiaS. BordoloiM. Molecular docking: Challenges, advances and its use in drug discovery perspective.Curr. Drug Targets201920550152110.2174/138945011966618102215301630360733
     [Google Scholar]
  47. BaxterB.T. PearceW.H. WaltkeE.A. LittooyF.N. HallettJ.W.Jr KentK.C. UpchurchG.R.Jr ChaikofE.L. MillsJ.L. FlecktenB. LongoG.M. LeeJ.K. ThompsonR.W. Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: Report of a prospective (Phase II) multicenter study.J. Vasc. Surg.200236111210.1067/mva.2002.12501812096249
     [Google Scholar]
  48. CurciJ.A. MaoD. BohnerD.G. AllenB.T. RubinB.G. ReillyJ.M. SicardG.A. ThompsonR.W. Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms.J. Vasc. Surg.200031232534210.1016/S0741‑5214(00)90163‑010664501
     [Google Scholar]
  49. DingR. McGuinnessC.L. BurnandK.G. SullivanE. SmithA. Matrix metalloproteinases in the aneurysm wall of patients treated with low-dose doxycycline.Vascular200513529029710.1258/rsmvasc.13.5.29016288704
     [Google Scholar]
  50. FranklinI.J. HarleyS.L. GreenhalghR.M. PowellJ.T. Uptake of tetracycline by aortic aneurysm wall and its effect on inflammation and proteolysis.Br. J. Surg.200286677177510.1046/j.1365‑2168.1999.01137.x10383577
     [Google Scholar]
  51. AxisaB. NaylorA.R. BellP.R.F. ThompsonM.M. Simple and reliable method of doxycycline determination in human plasma and biological tissues.J. Chromatogr., Biomed. Appl.2000744235936510.1016/S0378‑4347(00)00261‑910993525
     [Google Scholar]
  52. ShoE. ChuJ. ShoM. FernandesB. JuddD. GanesanP. KimuraH. DalmanR.L. Continuous periaortic infusion improves doxycycline efficacy in experimental aortic aneurysms.J. Vasc. Surg.20043961312132110.1016/j.jvs.2004.01.03615192574
     [Google Scholar]
  53. BartoliM.A. ParodiF.E. ChuJ. PaganoM.B. MaoD. BaxterB.T. BuckleyC. EnnisT.L. ThompsonR.W. Localized administration of doxycycline suppresses aortic dilatation in an experimental mouse model of abdominal aortic aneurysm.Ann. Vasc. Surg.200620222823610.1007/s10016‑006‑9017‑z16572291
     [Google Scholar]
  54. NosoudiN. Nahar-GohadP. SinhaA. ChowdhuryA. GerardP. CarstenC.G. GrayB.H. VyavahareN.R. Prevention of abdominal aortic aneurysm progression by targeted inhibition of matrix metalloproteinase activity with batimastat-loaded nanoparticles.Circ. Res.201511711e80e8910.1161/CIRCRESAHA.115.30720726443597
     [Google Scholar]
  55. NosoudiN. ChowdhuryA. SiclariS. ParasaramV. KaramchedS. VyavahareN. Systemic delivery of nanoparticles loaded with pentagalloyl glucose protects elastic lamina and prevents abdominal aortic aneurysm in rats.J. Cardiovasc. Transl. Res.201695-644545510.1007/s12265‑016‑9709‑x27542007
     [Google Scholar]
  56. YodsanitN. ShirasuT. HuangY. YinL. IslamZ.H. GreggA.C. RiccioA.M. TangR. KentE.W. WangY. XieR. ZhaoY. YeM. ZhuJ. HuangY. HoytN. ZhangM. HossackJ.A. SalmonM. KentK.C. GuoL.W. GongS. WangB. Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms.Bioact. Mater.202326526310.1016/j.bioactmat.2023.02.00936875050
     [Google Scholar]
  57. KarlssonL. BjörckM. PärssonH. WanhainenA. The association between serological markers for Chlamydophila pneumoniae and the development of abdominal aortic aneurysm.Ann. Vasc. Surg.201125332232610.1016/j.avsg.2010.09.00121126854
     [Google Scholar]
  58. WilsonW.R.W. AndertonM. ChokeE.C. DawsonJ. LoftusI.M. ThompsonM.M. Elevated plasma MMP1 and MMP9 are associated with abdominal aortic aneurysm rupture.Eur. J. Vasc. Endovasc. Surg.200835558058410.1016/j.ejvs.2007.12.00418226564
     [Google Scholar]
  59. InagakiE. FarberA. EslamiM.H. KalishJ. RybinD.V. DorosG. PeacockM.R. SiracuseJ.J. Preoperative hypoalbuminemia is associated with poor clinical outcomes after open and endovascular abdominal aortic aneurysm repair.J. Vasc. Surg.20176615363.e110.1016/j.jvs.2016.10.11028216349
     [Google Scholar]
  60. CerşitS. ÖcalL. KeskinM. GürsoyM.O. KalçikM. BayamE. KaradumanA. UysalS. UsluA. KüpA. DereliS. ArslantaşU. TürkmenM.M. Association of C-reactive protein-to-albumin ratio with the presence and progression of abdominal aortic aneurysm.Angiology202172215315810.1177/000331972095408432911951
     [Google Scholar]
  61. DavisV. PersidskaiaR. Baca-RegenL. ItohY. NagaseH. PersidskyY. GhorpadeA. BaxterB.T. Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms.Arterioscler. Thromb. Vasc. Biol.199818101625163310.1161/01.ATV.18.10.16259763536
     [Google Scholar]
  62. IidaY. XuB. XuanH. GloverK.J. TanakaH. HuX. FujimuraN. WangW. SchultzJ.R. TurnerC.R. DalmanR.L. Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression.Arterioscler. Thromb. Vasc. Biol.201333471872610.1161/ATVBAHA.112.30032923288157
     [Google Scholar]
  63. HadiT. BoytardL. SilvestroM. AlebrahimD. JacobS. FeinsteinJ. BaroneK. SpiroW. HutchisonS. SimonR. RateriD. PinetF. FenyoD. AdelmanM. MooreK.J. EltzschigH.K. DaughertyA. RamkhelawonB. Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells.Nat. Commun.201891502210.1038/s41467‑018‑07495‑130479344
     [Google Scholar]
  64. TaiH.C. TsaiP.J. ChenJ.Y. LaiC.H. WangK.C. TengS.H. LinS.C. ChangA.Y.W. JiangM.J. LiY.H. WuH.L. MaedaN. TsaiY.S. Peroxisome proliferator–activated receptor γ level contributes to structural integrity and component production of elastic fibers in the aorta.Hypertension20166761298130810.1161/HYPERTENSIONAHA.116.0736727045031
     [Google Scholar]
  65. GackoM. ChyczewskiL. ChrostekL. Distribution, activity and concentration of cathepsin B and cystatin C in the wall of aortic aneurysm.Pol. J. Pathol.1999502838610481531
     [Google Scholar]
  66. GaoP. GaoP. ZhaoJ. ShanS. LuoW. SlivanoO.J. ZhangW. TabuchiA. LeMaireS.A. MaegdefesselL. ShenY.H. MianoJ.M. SingerH.A. LongX. MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm.Redox Biol.20214110190310.1016/j.redox.2021.10190333667992
     [Google Scholar]
  67. HuY. LanY. RanQ. GanQ. HuangW. Analysis of the clinical efficacy and molecular mechanism of xuefu zhuyu decoction in the treatment of COPD based on meta-analysis and network pharmacology.Comput. Math. Methods Med.2022202212410.1155/2022/261558036479314
     [Google Scholar]
  68. LuP.D. YuanM.C. QuanX.P. ChenJ.F. ZhaoY.H. Preclinical studies of licorice in ulcerative colitis: A systematic review with meta-analysis and network pharmacology.J. Ethnopharmacol.202229611544410.1016/j.jep.2022.11544435671864
     [Google Scholar]
  69. KanM. FuH. XuY. YueZ. DuB. ChenQ. WangX. YuS. ZhangZ. Effects of once-weekly glucagon-like peptide-1 receptor agonists on type 2 diabetes mellitus complicated with coronary artery disease: Potential role of the renin-angiotensin system.Diabetes Obes. Metab.202325113223323410.1111/dom.1521937529870
     [Google Scholar]
  70. GolledgeJ. Abdominal aortic aneurysm: Update on pathogenesis and medical treatments.Nat. Rev. Cardiol.201916422524210.1038/s41569‑018‑0114‑930443031
     [Google Scholar]
  71. MorrisD.R. CunninghamM.A. AhimastosA.A. KingwellB.A. PappasE. BourkeM. ReidC.M. StijnenT. DalmanR.L. AalamiO.O. LindemanJ.H. NormanP.E. WalkerP.J. FitridgeR. BourkeB. DearA.E. PinchbeckJ. JaeggiR. GolledgeJ. TElmisartan in the management of abDominal aortic aneurYsm (TEDY): The study protocol for a randomized controlled trial.Trials201516127410.1186/s13063‑015‑0793‑z26081587
     [Google Scholar]
  72. Puertas-UmbertL. Almendra-PeguerosR. Jiménez-AltayóF. SirventM. GalánM. Martínez-GonzálezJ. RodríguezC. Novel pharmacological approaches in abdominal aortic aneurysm.Clin. Sci.2023137151167119410.1042/CS2022079537559446
     [Google Scholar]
/content/journals/cmc/10.2174/0109298673267204231115105934
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Evaluation of Roxithromycin as a Treatment Option for Small Abdominal Aortic Aneurysms: An Integrated Study of Meta-analysis and Network Pharmacology
Curr. Med. Chem. 32, 2750 (2025); https://doi.org/10.2174/0109298673267204231115105934
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  • Article Type:     Research Article
Keyword(s): Aneurysm; antibiotics; aortic; meta-analysis; network pharmacology; roxithromycin

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