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Abstract

Introduction

Hypertension is a major contributor to disability-adjusted life years (DALYs) worldwide, as highlighted by the Global Burden of Disease study (GBD 2021). Effective management of hypertension through medication can significantly lower the risks associated with the condition. It is important to recognize that not adhering to antihypertensive therapy often leads to negative health outcomes.

Methods

We conducted a thorough search of databases such as “Embase, PubMed, Web of Science, Cochrane Library, EBSCOHost, and Scopus” from their inception up to December 4th, 2023. This search focused on studies involving patients with hypertension. Our review specifically targeted studies conducted in India, published in English, and focused on the prevalence of non-adherence to antihypertensive medication. We used a random-effects model to pool the findings and assessed heterogeneity using the I2 statistic, with a significance level set at < 0.05. Subgroup analyses were performed to identify areas with a higher prevalence. This review was prospectively registered in PROSPERO (CRD42024489527).

Results

This review included 40 studies from India, encompassing 18,808 patients with hypertension. The pooled prevalence of non-adherence to antihypertensive medication was 48% (95% CI 39%-56%, PI = 9%-90%), with a high degree of heterogeneity (I2=98%). Meta-regression showed that non-adherence was linked to younger age (<0.01). Subgroup analysis revealed a varying prevalence across India, with the eastern region showing the highest prevalence at 76% (95% CI 31%-96%), followed by the order East > North > West > South ( < 0.01). A higher prevalence was also observed in community settings (51%) and rural areas (57%).

Discussion

Findings of this study shed light on the growing prevalence of nonadherence to antihypertensive medication among Indian hypertensive patients. Nonadherence patterns vary across settings and contexts, reinforcing the need for more longitudinal studies and context-specific targeted interventions. Subgroup analyses revealed no significant reduction in heterogeneity, highlighting the need for more qualitative studies.

Conclusion

Given the high and regionally variable prevalence of non-adherence to antihypertensive medication in India, it is crucial to develop localized strategies to improve adherence to hypertension treatment.

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2025-10-25

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References

  1. Sabaté E. Adherence to long-term therapies: Evidence for action. Geneva, Switzerland World Health Organization 2003
    [Google Scholar]
  2. Hedna K. Hakkarainen K.M. Gyllensten H. Adherence to antihypertensive therapy and elevated blood pressure: Should we consider the use of multiple medications? PLoS One 2015 10 9 0137451 10.1371/journal.pone.0137451 26359861
    [Google Scholar]
  3. Facts About Hypertension 2024 Available from: https://www.cdc.gov/high-blood-pressure/about/index.html
  4. Jin C.N. Yu C.M. Sun J.P. The healthcare burden of hypertension in Asia. Heart Asia 2013 5 1 238 243 10.1136/heartasia‑2013‑010408 27326143
    [Google Scholar]
  5. Gupta R. Gaur K.S. Ram C.V. Emerging trends in hypertension epidemiology in India. J. Hum. Hypertens. 2019 33 8 575 587 10.1038/s41371‑018‑0117‑3 30254382
    [Google Scholar]
  6. Prenissl J. Manne-Goehler J. Jaacks L.M. Hypertension screening, awareness, treatment, and control in India: A nationally representative cross-sectional study among individuals aged 15 to 49 years. PLoS Med. 2019 16 5 1002801 10.1371/journal.pmed.1002801 31050680
    [Google Scholar]
  7. Geldsetzer P. Manne-Goehler J. Theilmann M. Diabetes and Hypertension in India. JAMA Intern. Med. 2018 178 3 363 372 10.1001/jamainternmed.2017.8094 29379964
    [Google Scholar]
  8. Mahmood S. Jalal Z. Abdul Hadi M. Orooj H. Shah K.U. Non-adherence to prescribed antihypertensives in primary, secondary and tertiary healthcare settings in Islamabad, Pakistan: A cross-sectional study. Patient Prefer. Adherence 2020 14 73 85 10.2147/PPA.S235517 32021119
    [Google Scholar]
  9. Calderón-Larrañaga A. Diaz E. Poblador-Plou B. Gimeno-Feliu L.A. Abad-Díez J.M. Prados-Torres A. Non-adherence to antihypertensive medication: The role of mental and physical comorbidity. Int. J. Cardiol. 2016 207 310 316 10.1016/j.ijcard.2016.01.069 26814635
    [Google Scholar]
  10. Akeroyd J.M. Chan W.J. Kamal A.K. Palaniappan L. Virani S.S. Adherence to cardiovascular medications in the South Asian population: A systematic review of current evidence and future directions. World J. Cardiol. 2015 7 12 938 947 10.4330/wjc.v7.i12.938 26730300
    [Google Scholar]
  11. Morisky D.E. Ang A. Krousel-Wood M. Ward H.J. Predictive validity of a medication adherence measure in an outpatient setting. J. Clin. Hypertens. 2008 10 5 348 354 10.1111/j.1751‑7176.2008.07572.x 18453793
    [Google Scholar]
  12. Svarstad B.L. Chewning B.A. Sleath B.L. Claesson C. The brief medication questionnaire: A tool for screening patient adherence and barriers to adherence. Patient Educ. Couns. 1999 37 2 113 124 10.1016/S0738‑3991(98)00107‑4 14528539
    [Google Scholar]
  13. Kim M.T. Hill M.N. Bone L.R. Levine D.M. Development and testing of the hill‐bone compliance to high blood pressure therapy scale. Prog. Cardiovasc. Nurs. 2000 15 3 90 96 10.1111/j.1751‑7117.2000.tb00211.x 10951950
    [Google Scholar]
  14. Culig J. Leppée M. Boskovic J. Eric M. Determining the difference in medication compliance between the general patient population and patients receiving antihypertensive therapy: A case study. Arch. Pharm. Res. 2011 34 7 1143 1152 10.1007/s12272‑011‑0712‑0 21811921
    [Google Scholar]
  15. Nielsen J.Ø. Shrestha A.D. Neupane D. Kallestrup P. Non-adherence to anti-hypertensive medication in low- and middle-income countries: A systematic review and meta-analysis of 92443 subjects. J. Hum. Hypertens. 2017 31 1 14 21 10.1038/jhh.2016.31 27306087
    [Google Scholar]
  16. Abegaz T.M. Shehab A. Gebreyohannes E.A. Bhagavathula A.S. Elnour A.A. Nonadherence to antihypertensive drugs. Medicine 2017 96 4 5641 10.1097/MD.0000000000005641 28121920
    [Google Scholar]
  17. Mahmood S. Jalal Z. Hadi M.A. Khan T.M. Haque M.S. Shah K.U. Prevalence of non-adherence to antihypertensive medication in Asia: A systematic review and meta-analysis. Int. J. Clin. Pharm. 2021 43 3 486 501 10.1007/s11096‑021‑01236‑z 33515135
    [Google Scholar]
  18. Page M.J. Moher D. Bossuyt P.M. Boutron I. Hoffmann T.C. Mulrow C.D. PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews. BMJ 2021 372 n160 10.1136/bmj.n160 33781993
    [Google Scholar]
  19. Gandhi A.P. Shamim M.A. Padhi B.K. Steps in undertaking meta-analysis and addressing heterogeneity in meta-analysis. Evidence 2023 1 1 78 92
    [Google Scholar]
  20. Viechtbauer W. Cheung M.W.L. Outlier and influence diagnostics for meta-analysis. Res. Synth. Methods 2010 1 2 112 125 10.1002/jrsm.11 26061377
    [Google Scholar]
  21. Higgins J.P.T. Thompson S.G. Quantifying heterogeneity in a meta‐analysis. Stat. Med. 2002 21 11 1539 1558 10.1002/sim.1186 12111919
    [Google Scholar]
  22. Anil A. Shamim M.A. Saravanan A. Sandeep M. HPV DNA and p16INK4a positivity in vulvar cancer and vulvar intraepithelial neoplasia. Lancet Oncol. 2023 24 6 235 10.1016/S1470‑2045(23)00210‑3 37269853
    [Google Scholar]
  23. Shamim M.A. Gandhi A.P. Dwivedi P. Padhi B.K. How to perform meta-analysis in R: A simple yet comprehensive guide. Evidence 2023 1 1 93 113
    [Google Scholar]
  24. Ali S.H. An epidemiological study of hypertension and diabetes with special reference to alcohol and tobacco addiction and treatment compliance in above 40 years age group in a slum area of Chennai. J. Evol. Med. Dent. Sci. 2012 1 1 9 15 10.14260/jemds/2
    [Google Scholar]
  25. Aslami A.N. Jobby A. Compliance to hypertension treatment in residents of a fishermen colony in district Kollam, Kerala. Nepal J. Epidemiol. 2015 5 2 480 487 10.3126/nje.v5i2.12830 26913207
    [Google Scholar]
  26. Balasubramanian A. Nair S. Rakesh P.S. Leelamoni K. Adherence to treatment among hypertensives of rural Kerala, India. J. Family Med. Prim. Care 2018 7 1 64 69 10.4103/jfmpc.jfmpc_423_16 29915735
    [Google Scholar]
  27. Bhandari S. Sarma P.S. Thankappan K.R. Adherence to antihypertensive treatment and its determinants among urban slum dwellers in Kolkata, India. Asia Pac. J. Public Health 2015 27 2 NP74 NP84 10.1177/1010539511423568 22087037
    [Google Scholar]
  28. Chaudhary A.P. George J. Kadowade K. Faiyza L. Anjum R. Uma V.M. Evaluation of medication adherence and associated factors in hypertensive patients in bangalore, india; A cross-sectional study. Int. J. Pharm. Investig. 2021 11 4 426 431 10.5530/ijpi.2021.4.76
    [Google Scholar]
  29. Dharan D.R. Kt M. Factors influencing compliance to therapeutic regimen among patients with hypertension. Asian J. Pharm. Clin. Res. 2017 10 12 286 289 10.22159/ajpcr.2017.v10i12.21034
    [Google Scholar]
  30. Dilipkrishnan K. Gopalakrishnan G. A pilot study on medication adherence, patient satisfaction, kap and quality of life of hypertensive patients. Int. J. Pharm. Investig. 2023 13 2 329 334 10.5530/ijpi.13.2.043
    [Google Scholar]
  31. Girdhar S. Chaudhary A. Bansal N.R. Kaur P. Grewal A. Epidemiological correlates of adherence to anti-hypertensive treatment in primary health care setting of Ludhiana, Punjab. Int. J. Community Med. Public Health 2022 9 8 3214 10.18203/2394‑6040.ijcmph20222026
    [Google Scholar]
  32. kumar S. Treatment adherence among people living with hypertension in periurban community of chandigarh: A cross sectional study. Indian J Res 2019 8 9 2250
    [Google Scholar]
  33. Jhaj R. Gour P. Kumari S. Sharma S. Association between medication adherence and blood pressure control in urban hypertensive patients in central India. Int. J. Noncommun. Dis. 2018 3 1 9 10.4103/jncd.jncd_29_16
    [Google Scholar]
  34. Johnson J. Vijayakumar K. Nujum Z.T. Thankamoniamma P.M. Compliance and its determinants to pharmacologic management of hypertension. Indian J. Community Health 2019 31 1 63 72 10.47203/IJCH.2019.v31i01.011
    [Google Scholar]
  35. Kakumani K.V. Waingankar P. Assessment of compliance to treatment of diabetes and hypertension amongst previously diagnosed patients from rural community of raigad district of Maharashtra. J. Assoc. Physicians India 2016 64 12 36 40 28405986
    [Google Scholar]
  36. V K. Adhikary T. Sarma R. Ravi S. Purushotham A. Hegde S.K. Comparison of anti-hypertensive medication compliance between the tea tribe community and the non-tea tribe community seeking treatment from mobile medical units of Assam. Clin. Epidemiol. Glob. Health 2023 22 101317 10.1016/j.cegh.2023.101317
    [Google Scholar]
  37. Lata K. Adherence to treatment of hypertension: A comparison amongst patients registered in health facilities in rural and urban areas of a district in Rajasthan. Inter J Pharma Clin Res 2023 15 7 185 190
    [Google Scholar]
  38. Mishra S. Assessment of treatment adherence among hypertensive patients in a coastal area of Karnataka, India. Int. J. Community Med. Public Health 2017 3 8 1998 2003
    [Google Scholar]
  39. Mathur D. Deora S. Kaushik A. Bhardwaj P. Singh K. Awareness, medication adherence, and diet pattern among hypertensive patients attending teaching institution in western Rajasthan, India. J. Family Med. Prim. Care 2020 9 5 2342 2349 10.4103/jfmpc.jfmpc_193_20 32754499
    [Google Scholar]
  40. Misra P. Salve H.R. Srivastava R. Kant S. Krishnan A. Adherence to treatment among hypertensive individuals in a rural population of North India. Indian J. Community Health 2017 29 2 176 181 10.47203/IJCH.2017.v29i02.009
    [Google Scholar]
  41. Mutneja E. Yadav R. Dey A.B. Gupta P. Frequency and predictors of compliance among patients taking antihypertensive medicines. Indian Heart J. 2020 72 2 136 139 10.1016/j.ihj.2020.03.008 32534690
    [Google Scholar]
  42. Nagarkar A.M. Gadhave S.A. Sharma I. Choure A. Morisky D. Factors influencing medication adherence among hypertensive patients in a tertiary care hospital, Pune, Maharashtra. Natl. J. Community Med. 2013 4 4 559 563
    [Google Scholar]
  43. Rao C.R. Kamath V.G. Shetty A. Kamath A. Treatment compliance among patients with hypertension and type 2 diabetes mellitus in a coastal population of southern India. Int. J. Prev. Med. 2014 5 8 992 998 25489447
    [Google Scholar]
  44. Sarkar A. Makwana M.A. Pithadia P. Compliance to antihypertensive therapy and its predictors: A cross-sectional study in western coastal region of india. J. Clin. Diagn. Res. 2018 12 3 26 30
    [Google Scholar]
  45. Shah A. Singh V. Patil S. Gadkari M. Ramchandani V. Doshi K. Factors affecting compliance to antihypertensive treatment among adults in a tertiary care hospital in Mumbai. Indian J. Community Med. 2018 43 1 53 55 10.4103/ijcm.IJCM_40_17 29531441
    [Google Scholar]
  46. Shalini, Goel MK. Non-adherence to anti-hypertensive treatment. Indian J. Community Health 2020 32 1 126 129 10.47203/IJCH.2020.v32i01.025
    [Google Scholar]
  47. Sheilini M. Hande H.M. Devi E.S. Determinants of adherence to antihypertensives among elderly: A multifactorial concern. Patient Prefer. Adherence 2022 16 3185 3193 10.2147/PPA.S389437 36514803
    [Google Scholar]
  48. Singh P. Gupta R.K. Jan R. Raina S.K. Adherence for medication among self-reporting rural elderly with diabetes and hypertension. J Med Soc 2017 31 2 86 89 10.4103/jms.jms_48_16
    [Google Scholar]
  49. Sudharsanan N. Ali M.K. McConnell M. Hypertension knowledge and treatment initiation, adherence, and discontinuation among adults in Chennai, India: A cross-sectional study. BMJ Open 2021 11 1 040252 10.1136/bmjopen‑2020‑040252 33472779
    [Google Scholar]
  50. Sutar P. Shah H. A study of adherence pattern toward antihypertensive therapy (antihypertensive drugs, dietary habits, and physical activity) and certain factors affecting it. Int. J. Med. Sci. Public Health 2017 6 3 1 10.5455/ijmsph.2017.0847930082016
    [Google Scholar]
  51. Tabassum N. Rao R.L. A study on adherence to therapy among hypertensives in urban slums of Hyderabad. Int. J. Health Sci. Res. 2017 7 12 180 186
    [Google Scholar]
  52. Dennis T Meera N.K. Binny K. Sekhar M.S. Kishore G. Sasidharan S. Medication adherence and associated barriers in hypertension management in India. CVD Prev. Contr. 2011 6 1 9 13
    [Google Scholar]
  53. Venkatachalam J. Abrahm S. Singh Z. Stalin P. Sathya G.R. Determinants of patient′s adherence to hypertension medications in a rural population of Kancheepuram District in Tamil Nadu, South India. Indian J. Community Med. 2015 40 1 33 37 10.4103/0970‑0218.149267 25657510
    [Google Scholar]
  54. Choudhary R. Sharma S.M. Kumari V. Gautam D. Awareness, treatment adherence and risk predictors of uncontrolled hypertension at a tertiary care teaching hospital in Western India. Indian Heart J. 2016 68 Suppl. 2 S251 S252 10.1016/j.ihj.2016.08.003 27751307
    [Google Scholar]
  55. Choudhary R. Gautam D.K. Sharma S.M. Abstract P162: Drug adherence in hypertensive patients and variables associated with nonadherence. Hypertension 2020 76 Suppl. 1 AP162 10.1161/hyp.76.suppl_1.P162
    [Google Scholar]
  56. Kale S. Patil A. Mandlecha R.H. Compliance and adverse drug effects of antihypertensives in rural India. J. Clin. Diagn. Res. 2011 5 4 775 779
    [Google Scholar]
  57. Mathew A. Paluri V. Venkateswaramurthy N. A study on impact of clinical pharmacist interventions on relationship between treatment satisfaction and medication adherence in hypertensive patients. J Pharma Sci Res 2016 8 4 190 197
    [Google Scholar]
  58. Mathew R.A. Johnson S. Jose S. Chakraborty S. N K, Gowda V. A comparative study of monotherapy versus combination therapy in patients with stage-1 hypertension in terms of efficacy and cost effectiveness and to assess the medication adherence. Int J Res Pharm Sci 2018 9 1 147 153 10.26452/ijrps.v9i1.1216
    [Google Scholar]
  59. Meena J.K. Rustagi N. A0471 compliance and complications of hypertension treatment among lifestyle clinic patients, jodhpur, india. J. Hypertens. 2018 36 102 10.1097/01.hjh.0000548405.16163.29
    [Google Scholar]
  60. Punna S. Kodudula S. Adherence to antihypertensive medications and its determinants among adult hypertensive patients. J Krish Instit Med Sci 2022 11 4
    [Google Scholar]
  61. Santra G. Assessment of adherence to cardiovascular medicines in rural population: An observational study in patients attending a tertiary care hospital. Indian J. Pharmacol. 2015 47 6 600 604 10.4103/0253‑7613.169573 26729949
    [Google Scholar]
  62. Tejus A. Shukla G. Vishnuprasad R. Pradhan S. Prakash M.S. A prospective study to assess the medication adherence pattern among hypertensives and to evaluate the use of cellular phone text messaging as a tool to improve adherence to medications in a tertiary health-care center. Indian J. Pharmacol. 2020 52 4 290 295 10.4103/ijp.IJP_498_19 33078730
    [Google Scholar]
  63. Swami P.A. Kumar R.T.S. Babu S.M. Assessing the medication adherence of metabolic disorders in South India. J. Pharm. Res. Int. 2021 33 28B 52 59 10.9734/jpri/2021/v33i28B31538
    [Google Scholar]
  64. Buckley L. Labonville S. Barr J. A systematic review of beliefs about hypertension and its treatment among African Americans. Curr. Hypertens. Rep. 2016 18 7 52 10.1007/s11906‑016‑0662‑5 27193774
    [Google Scholar]
  65. Waeber B Feihl F Assessment of drug compliance in patients with high blood pressure resistant to antihypertensive therapy. EuroInter-vention 2013; 9 (R) R29 R34 10.4244/EIJV9SRA6 23732152
    [Google Scholar]
  66. Lewis L.M. Factors associated with medication adherence in hypertensive blacks: A review of the literature. J. Cardiovasc. Nurs. 2012 27 3 208 219 10.1097/JCN.0b013e318215bb8f 21760525
    [Google Scholar]
  67. Pladevall M. Brotons C. Gabriel R. Multicenter cluster-randomized trial of a multifactorial intervention to improve antihypertensive medication adherence and blood pressure control among patients at high cardiovascular risk (the COM99 study). Circulation 2010 122 12 1183 1191 10.1161/CIRCULATIONAHA.109.892778 20823391
    [Google Scholar]
  68. Conn V.S. Enriquez M. Ruppar T.M. Chan K.C. Meta-analyses of theory use in medication adherence intervention research. Am. J. Health Behav. 2016 40 2 155 171 10.5993/AJHB.40.2.1 26931748
    [Google Scholar]
  69. Ghembaza M.A. Senoussaoui Y. Tani M. Meguenni K. Impact of patient knowledge of hypertension complications on adherence to antihypertensive therapy. Curr. Hypertens. Rev. 2014 10 1 41 48 10.2174/157340211001141111160653 25392143
    [Google Scholar]
  70. Pati S. Sinha R. Panda M. Puri P. Pati S. Profile of multimorbidity in outpatients attending public healthcare settings. J. Family Med. Prim. Care 2021 10 8 2900 2914 10.4103/jfmpc.jfmpc_2436_20 34660423
    [Google Scholar]
  71. Kumari R. Raman R. Regional disparities in healthcare services in Uttar Pradesh, India: A principal component analysis. GeoJournal 2022 87 6 5027 5050 10.1007/s10708‑021‑10542‑y
    [Google Scholar]
  72. Pati S. Swain S. Knottnerus J.A. Metsemakers J.F.M. van den Akker M. Magnitude and determinants of multimorbidity and health care utilization among patients attending public versus private primary care: A cross-sectional study from Odisha, India. Int. J. Equity Health 2020 19 1 57 10.1186/s12939‑020‑01170‑y 32349770
    [Google Scholar]
  73. Jayaprakash P. Majumdar R. Ingole S. Geographical health inequalities in India: The impact of the COVID-19 pandemic on healthcare access and healthcare inequality. Int. J. Health Care Qual. Assur. 2024 37 3/4 42 67 10.1108/IJHCQA‑05‑2023‑0030 39548662
    [Google Scholar]
  74. Lee E.K.P. Poon P. Yip B.H.K. Global burden, regional differences, trends, and health consequences of medication nonadherence for hypertension during 2010 to 2020: A meta‐analysis involving 27 million patients. J. Am. Heart Assoc. 2022 11 17 026582 10.1161/JAHA.122.026582 36056737
    [Google Scholar]
  75. Pati M.K. Bhojani U. Elias M.A. Srinivas P.N. Improving access to medicines for non-communicable diseases in rural primary care: Results from a quasi-randomized cluster trial in a district in South India. BMC Health Serv. Res. 2021 21 1 770 10.1186/s12913‑021‑06800‑x 34348723
    [Google Scholar]
  76. Durand H. Hayes P. Morrissey E.C. Medication adherence among patients with apparent treatment-resistant hypertension. J. Hypertens. 2017 35 12 2346 2357 10.1097/HJH.0000000000001502 28777133
    [Google Scholar]
  77. Chen S.L. Lee W.L. Liang T. Liao I.C. Factors associated with gender differences in medication adherence: A longitudinal study. J. Adv. Nurs. 2014 70 9 2031 2040 10.1111/jan.12361 24506542
    [Google Scholar]
  78. Clancy K. Gove W. Sex differences in mental illness: An analysis of response bias in self-reports. Am. J. Clin. Hypn. 1972 14 3 205 216 10.1080/00029157.1972.10402184 4671624
    [Google Scholar]
  79. Thunander Sundbom L. Bingefors K. Women and men report different behaviours in, and reasons for medication non-adherence: A nationwide Swedish survey. Pharm. Pract. 2012 10 4 207 221 10.4321/S1886‑36552012000400005 24155839
    [Google Scholar]
  80. Bauhoff S. Self-report bias in estimating cross-sectional and treatment effects. In: Encyclopedia of Quality of Life and Well-Being Research. Dordrecht Springer 2024
    [Google Scholar]
  81. Gupta S. Dhamija J.P. Mohan I. Gupta R. Qualitative study of barriers to adherence to antihypertensive medication among rural women in India. Int. J. Hypertens. 2019 2019 1 1 7 10.1155/2019/5749648 30809390
    [Google Scholar]
  82. Mamaghani E.A. Hasanpoor E. Maghsoodi E. Soleimani F. Barriers to medication adherence among hypertensive patients in deprived rural areas. Ethiop. J. Health Sci. 2020 30 1 85 94 10.4314/ejhs.v30i1.11 32116436
    [Google Scholar]
  83. Magnabosco P. Teraoka E.C. Oliveira E.M. Felipe E.A. Freitas D. Marchi-Alves L.M. Comparative analysis of non-adherence to medication treatment for systemic arterial hypertension in urban and rural populations. Rev. Lat. Am. Enfermagem 2015 23 1 20 27 10.1590/0104‑1169.0144.2520 25806627
    [Google Scholar]
  84. El Alili M. Vrijens B. Demonceau J. Evers S.M. Hiligsmann M. A scoping review of studies comparing the medication event monitoring system (MEMS) with alternative methods for measuring medication adherence. Br. J. Clin. Pharmacol. 2016 82 1 268 279 10.1111/bcp.12942 27005306
    [Google Scholar]
  85. Gutierrez M.M. Sakulbumrungsil R. Factors associated with medication adherence of hypertensive patients in the Philippines: A systematic review. Clin. Hypertens. 2021 27 1 19 10.1186/s40885‑021‑00176‑0 34593047
    [Google Scholar]
  86. Ruksakulpiwat S. Schiltz N. Irani E. Josephson R. Adams J. Still C. Medication adherence of older adults with hypertension: A systematic review. Patient Prefer. Adherence 2024 18 957 975 10.2147/PPA.S459678 38737487
    [Google Scholar]
  87. Izeogu C. Kalinowski J. Schoenthaler A. Strategies to improve adherence to anti-hypertensive medications: A narrative review. Curr. Hypertens. Rep. 2020 22 12 105 10.1007/s11906‑020‑01115‑4 33165652
    [Google Scholar]
  88. Ghozzi H. Kassis M. Hakim A. Medication adherence of a sample of hypertensive patients in the region of Sfax (Tunisia). Ann. Cardiol. Angeiol. 2010 59 3 131 137 10.1016/j.ancard.2010.04.004 20510914
    [Google Scholar]
  89. Ikama M.S. Nsitou B.M. Loumouamou M. Kimbally-Kaky G. Nkoua J.L. Drug compliance and its factors in a group of hypertensive Congolese. Pan Afr. Med. J. 2013 15 121 10.11604/pamj.2013.15.121.2435 24255727
    [Google Scholar]
  90. Azevedo R.B. Botelho B.G. Hollanda J.V.G. Covid-19 and the cardiovascular system: A comprehensive review. J. Hum. Hypertens. 2021 35 1 4 11 10.1038/s41371‑020‑0387‑4 32719447
    [Google Scholar]
  91. Clark C.E. McDonagh S.T.J. McManus R.J. Martin U. COVID-19 and hypertension: Risks and management. A scientific statement on behalf of the British and Irish hypertension society. J. Hum. Hypertens. 2021 35 4 304 307 10.1038/s41371‑020‑00451‑x 33483621
    [Google Scholar]
  92. Ran J. Song Y. Zhuang Z. Blood pressure control and adverse outcomes of COVID-19 infection in patients with concomitant hypertension in Wuhan, China. Hypertens. Res. 2020 43 11 1267 1276 10.1038/s41440‑020‑00541‑w 32855527
    [Google Scholar]
  93. Pio M. Baragou S. Afassinou Y. Adherence to hypertension and its determinants in the cardiology department of the University Hospital of Lomé Tokoin. Pan Afr. Med. J. 2013 14 48 10.11604/pamj.2013.14.48.1973 23560131
    [Google Scholar]
  94. Murphy G.K. McAlister F.A. Weir D.L. Tjosvold L. Eurich D.T. Cardiovascular medication utilization and adherence among adults living in rural and urban areas: A systematic review and meta-analysis. BMC Public Health 2014 14 1 544 10.1186/1471‑2458‑14‑544 24888355
    [Google Scholar]
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Prevalence of Non-Adherence to Antihypertensive Medication in India: A Systematic Review and Meta-Analysis of 18,808 Hypertensive Patients
Bentham Science Publishers ; https://doi.org/10.2174/0115734021377630250903105143
/content/journals/chyr/10.2174/0115734021377630250903105143
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  • Article Type:     Research Article
Keywords: antihypertensive medication ; Hypertension ; adherence ; non-adherence

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