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2000
Volume 23, Issue 1
  • ISSN: 1570-162X
  • E-ISSN: 1873-4251

Abstract

Background

Circulating recombinant form (CRF) 01_AE and subtype C are two HIV-1 subtypes. In recent years, novel HIV-1 recombinant forms have become more and more prevalent in China; however, new HIV-1 CRF01_AE/C recombinant forms are less prevalent nationwide.

Objective

Our study aimed to investigate new recombinant forms between different HIV-1 subtypes and evaluate their transmission risk among men who have sex with men (MSM) in Hebei, China.

Methods

The near full-length genome (NFLG) of HIV-1 was identified using the analyses of the phylogenetic tree and gene breakpoints.

Results

In the present work, we have reported a novel HIV-1 recombinant form composed of CRF01_AE and subtype C. The NFLG of this CRF01_AE/C form contained eight gene subregions, with four subtype C gene segments inserted into the CRF01_AE backbone, consisting of I CRF01_AE (790–1,171 nt), II subtype C (1,172–1,840 nt), III CRF01_AE (1,841–5,089 nt), IV subtype C (5,090–5,666 nt), V CRF01_AE (5,667–6,317 nt), VI subtype C (6,318–8,586 nt), VII CRF01_AE (8,587–9,246 nt), and VIII subtype C (9,247–9,409 nt). This new recombinant form was identified as CRF140_0107.

Conclusion

The study suggested that it is important to monitor HIV-1 diversity to reduce HIV-1 transmission in China.

© 2025 Bentham Science Publishers
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2025-02-06
2025-09-28

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/content/journals/chr/10.2174/011570162X369438250131065639
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Identification of a Novel HIV-1 Recombinant Form Comprising CRF01_AE and Subtype C in Hebei Province, China
Cur. HIV Res. 23, 53 (2025); https://doi.org/10.2174/011570162X369438250131065639
/content/journals/chr/10.2174/011570162X369438250131065639
/content/journals/chr/10.2174/011570162X369438250131065639
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  • Article Type:     Research Article
Keyword(s): CRF01_AE; full-length genome (NFLG) of HIV-1; HIV-1; homosexual; recombinant form; subtype C

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