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2000
Volume 23, Issue 1
  • ISSN: 1570-162X
  • E-ISSN: 1873-4251

Abstract

Aims

In people living with human immune deficiency (PLHIV), the rates of human papillomavirus (HPV) infection, mixed types, and high-risk (HR) strains increase, while the virus clearance does not occur. Here, we report HPV genotyping in PLHIVs from Iran and the Middle East region for the first time.

Methods

HPV genotyping in referring individuals from different provinces to our laboratory was evaluated over 2023-2024. For this, the HPV types in specimens were detected through the INNO-LiPA HPV genotyping kit. Statistical analysis was conducted with a 95% confidence interval (95%CI) and < 0.05. Accordingly, 481 subjects from various provinces participated in this study.

Results

The rate of HPV infection was 45.7%, of which 14% were HIV-infected women referred from all provinces. The most prevalent types included 6, 51, and 18, but not 16 HR types. Mixed infections in dually infected women were significantly more than in HPV-infected ones. The HPV+/HIV+ subgroup had the lowest median age. The prevalence of HPV types and mixed infection in PLHIVs was congruent with the previous reports, except for the low rate of type 16 infection, perhaps due to the healthy nature of our subjects. Only HIV+/HPV+ cases' age was similar to the previous reports, perhaps because of sample collection and study designs. Among all factors, age and gender affected the HPV type distribution notably.

Conclusion

The current study corroborated the results of many prior reports, demonstrating the considerable impact of HIV status on HPV distribution. The authors recommend implementing a national HPV vaccination and more comprehensive reports of HPV genotyping in PLHIVs.

© 2025 Bentham Science Publishers
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2025-08-27

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First Report of HPV Genotyping and Distribution in People Living with and Without HIV from Iran and the Middle East
Current HIV Research 23, 44 (2025); https://doi.org/10.2174/011570162X352564250112035117
/content/journals/chr/10.2174/011570162X352564250112035117
/content/journals/chr/10.2174/011570162X352564250112035117
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Supplements

S1: Table of demographic data and HPV genotyping distribution in HIV-infected and uninfected groups. S2: Table of LR, HR, and HR-LR HPV types of mixed infections and their frequency in HIV-positive and negative groups.

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  • Article Type:     Research Article
Keyword(s): high-risk HPV; HIV infectivity; HPV genotyping; HPV vaccination; HPV-HIV coinfection; mixed infections

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