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2000
Volume 23, Issue 4
  • ISSN: 1871-5257
  • E-ISSN: 1875-6182

Abstract

Background

Pulmonary Hypertension (PH) is a significant contributor to cardiac mortality in Dilated Cardiomyopathy (DCM) patients. Inflammatory processes and oxidative stress play pivotal roles in the advancement of Pulmonary Hypertension (PH). The Monocyte-to-High-Density-Lipoprotein Cholesterol Ratio (MHR), a newly identified biomarker indicative of inflammatory and oxidative stress, has not been extensively researched in the context of pulmonary hypertension, especially within the scope of dilated cardiomyopathy.

Objectives

Given the reason mentioned above, our research explores the correlation between the MHR and the severity of PH in patients suffering from DCM.

Methods

In this study, we conducted a retrospective review of medical data from 107 individuals diagnosed with non-ischemic DCM, evaluating their clinical profiles, biochemical indicators, MHR, and echocardiographic parameters. We analyzed the relationships between Pulmonary Arterial Systolic Pressure (PASP) and the Ejection Fraction of the Left Ventricle (LVEF). Utilizing logistic regression analysis, we determined the predictors of PH.

Results and Discussion

Findings indicated that the DCM-PH group exhibited a significantly larger male population and elevated New York Heart Association (NYHA) classification scores (both with -values <0.001 and 0.01, respectively) compared to the DCM-only group. A positive association was observed between the PASP and parameters, such as the Dimensions of the Left Atrium (LAD) and Left Ventricle in Systole (LVDs), Monocyte (M) levels, Direct Bilirubin (DB), and MHR. Conversely, an inverse relationship was noted with serum lipid profiles, including Total Cholesterol (TC), HDL Cholesterol (HDL-c), and apolipoprotein A1. LVEF demonstrated positive linkage with the same lipid profiles and the Left Ventricular Posterior Wall Thickness (LVPWT) yet showed negative correlations with the NYHA classification, Red Blood Cell Distribution Width Standard Deviation (RDW-SD), Total Bilirubin (TB), Direct Bilirubin (DB), and dimensions of the left ventricle in diastole and systole, as well as MHR. Through logistic regression analysis, several factors were recognized as significant predictors for the severity of PH within the DCM cohort, with weight (OR1.20, CI 1.022-1.409, =0.026), RDW-SD (OR1.988, CI 1.015-3.895, =0.045), LVPW (OR3.577, CI 1.307-9.792, =0.013), LVDd (OR1.333, CI 1.058-1.680, =0.015), MHR (OR3.575, CI 1.502-8.506, =0.032), and TB (OR1.416, CI 1.014-1.979, =0.041) showing positive associations, while apoB (OR0.001 CI0.001-0.824, =0.045) exhibiting negative associations, all with -values <0.05.

Conclusion

Higher MHR and LVD correlate with increased PASP and reduced LVEF in DCM-PH patients. MHR and LVPW are independent predictors of PH severity, indicating their potential as novel severity markers in DCM-related PH.

© 2025 Bentham Science Publishers
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2025-09-03
2026-02-04

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The Predictive Value of Monocyte-to-HDL Cholesterol Ratio in Patients with Dilated Cardiomyopathy and Associated Pulmonary Hypertension
Cardiovasc. Hematol. Agents Med. Chem. 23, 299 (2025); https://doi.org/10.2174/0118715257294388250326034612
/content/journals/chamc/10.2174/0118715257294388250326034612
/content/journals/chamc/10.2174/0118715257294388250326034612
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  • Article Type:     Research Article
Keyword(s): dilated cardiomyopathy; left ventricular ejection fraction; monocyte to high-density lipoprotein cholesterol ratio; New York heart association (NYHA); pulmonary artery systolic pressure; Pulmonary hypertension

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