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2000
Volume 3, Issue 3
  • ISSN: 2666-8629
  • E-ISSN: 2666-8637

Abstract

Objective

The goal of this study was to profile the secondary metabolites of two ripe-light and dark-stages of fruit and the assessment of their antioxidant and anti-proliferative activities.

Methods

Secondary metabolites were profiled by GC-MS. It should read: Radical scavanging activity while MTS assays were employed to assess effect on cell proliferation on normal and malignant cells. Impact on the activity of CYP1B1, an enzyme known to activate polyaromatic hydrocarbons, was also assessed.

Results

One hundred and twenty-three (123) metabolites were identified. DPPH activity showed a dose-dependent response to fruit extracts, and HO scavenging activity increased with concentrations. Anti-proliferative properties using the MTS assay on prostate, breast and colon cancer cells and normal prostate cell lines revealed a relatively weak impact on the examined cells. DCM extracts exhibited inhibition of the activity of human cytochrome P450 1B1 enzyme.

Conclusion

Results showed that fruit extracts demonstrated significant antioxidant activity, while they did not show cytotoxic effects on normal or cancer cells. DCM and hexane extracts showed noticeable inhibition of CYP1B1 enzyme, suggestive of a chemoprotective potential.

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2024-11-11
2025-09-04

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Profiling Secondary Metabolites of Governor’s Plum<span class="jp-italic">&nbsp;Flacourtia indica</span> (Burm.f. Merr.) Fruit and their Potential Antioxidant and Chemopreventive Values
Curr Func Foods 3, E26668629335269 (2025); https://doi.org/10.2174/0126668629335269241010050725
/content/journals/cff/10.2174/0126668629335269241010050725
/content/journals/cff/10.2174/0126668629335269241010050725
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  • Article Type:     Research Article
Keyword(s): anti-proliferative; antioxidant; chemopreventive; Flacourtia indica; profiling; Secondary metabolites

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