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Abstract

Objective

Menopause causes various health problems and is related to changes in gut microbiota. Obeticholic acid can improve various postmenopausal diseases associated with increased risk by altering gut microbiota, but research on the impact of obeticholic acid on postmenopausal is still unclear.

Methods

Ovariectomy was performed on female C57BL/6J mice, and obeticholic acid intervention was administered by gavage. Plasma estradiol, diamine oxidase, and bacterial lipopolysaccharide levels were detected by ELISA, and fecal archaea, bacteria, fungi, and viruses’ diversity and relative abundance were detected by metagenomics.

Results

Ovariectomy significantly reduced plasma estradiol levels in mice and significantly increased plasma diamine oxidase and bacterial lipopolysaccharides. Obeticholic acid did not significantly alter plasma estradiol levels in ovariectomized mice, but significantly reduced plasma diamine oxidase and bacterial lipopolysaccharides, and significantly altered the diversity of fecal archaea, bacteria, and fungi in OVX mice, and changed the relative abundance of multiple microorganisms. It did not significantly alter microbial function but significantly altered microbial virulence factors.

Conclusion

Obeticholic acid improved the intestinal barrier and has a regulatory effect on the diversity of fecal microbiota in ovariectomized mice.

© 2025 The Author(s). Published by Bentham Science Publisher. The Author(s)
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode.
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2025-06-23
2025-09-14

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Effectso Obeticholi Aci o Intestinal Barrier and Fecal Microbiota Diversity in Ovariectomized Mice
Bentham Science Publishers ; https://doi.org/10.2174/0115748855379717250610083512
/content/journals/cdth/10.2174/0115748855379717250610083512
/content/journals/cdth/10.2174/0115748855379717250610083512
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  • Article Type:     Research Article
Keywords: oophorectomy ; feces ; menopause ; microbial diversity ; Obeticholic acid ; intestinal barrier

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