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In recent years there has been increased interest in exploring the therapeutic efficacy of cannabis for the management of chronic pain among adult patients. However, the use of cannabis for chronic pain is still a matter of debate and uncertainty. This opinion paper carried out a short overview of the literature with the aim of evaluating data on efficacy and safety of cannabis-based medicines, to fill the existing gaps in understanding the role of cannabis in therapy and to identify the critical issues associated with their use. The analysis of existing literature has clearly highlighted the potential benefits of cannabis-based preparations for the management of chronic pain. However, several criticalities have been identified. These include the lack of standardization of preparations and the insufficient clinical evidence to establish cannabis as the therapy of choice for chronic pain. As a result, although the potential benefits of cannabis preparations for the management of chronic pain are clear, further research is needed to address existing limitations and establish a solid scientific basis, especially through real-world data collection.
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