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2000
Volume 22, Issue 8
  • ISSN: 1567-2018
  • E-ISSN: 1875-5704

Abstract

Introduction

Polymer prodrug nanoparticles have become an emerging drug delivery system in cancer therapy due to their high drug loading. However, their poor drug release and lack of tumor cell targeting limit their clinical application.

Objective

This study aimed to prepare targeted and reduction-reactive polyprodrug nanocarriers based on curcumin (CUR) for co-delivery of doxorubicin (DOX), labeled as DOX/HAPCS NPs, and to investigate their anticancer activity.

Methods

The polymer was synthesized and characterized by chemical method. The drug loading and drug release behavior of DOX and CUR in polymer nanoparticles were determined. Moreover, the antitumor effects of polymer nanoparticles were evaluated using an MTT experiment and tumor inhibition experiment, and the synergistic effect of co-delivered DOX and CUR was explored.

Results

The particle size of DOX/HAPCS NPs was 152.5nm, and the potential was about -26.74 mV. The drug loading capacity of DOX and CUR was about 7.56% and 34.75%, respectively, indicating high drug loading capacity and good stability. DOX and CUR released over 90% within 24 hours in the tumor environment. Compared with free DOX, DOX/HAPCS NPs demonstrated significantly enhanced cell and tumor inhibitory effects (0.05) and and changed drug distribution to avoid toxic side effects on normal tissues. The combined index showed that DOX and CUR showed synergistic anticancer effects at a set ratio.

Conclusion

The prepared reduction-responsive targeted polymer nanomedical DOX/HAPCS NPs exhibited a synergistic anti-cancer effect, with high drug loading capacity and the ability to release drugs in proportion, making it a promising polymer nanoparticle drug delivery system.

© 2025 Bentham Science Publishers
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/content/journals/cdd/10.2174/0115672018314506240723080113
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Reduction-Responsive Polyprodrug Nanoplatform Based on Curcumin for Tumor-Targeted Therapy
Curr. Drug Deliv. 22, 1166 (2025); https://doi.org/10.2174/0115672018314506240723080113
/content/journals/cdd/10.2174/0115672018314506240723080113
/content/journals/cdd/10.2174/0115672018314506240723080113
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  • Article Type:     Research Article
Keyword(s): curcumin; doxorubicin; drug delivery system; hepatocarcinoma; nanoparticle; Polyprodrug; reduction response; stimuli-sensitive polymers

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