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2000
Volume 22, Issue 8
  • ISSN: 1567-2018
  • E-ISSN: 1875-5704

Abstract

Introduction

Obesity has become a pressing global health crisis, reaching alarming proportions and bearing significant consequences for public health on a global scale.

Aim

In this research, chitosan nanoparticles were employed to encapsulate ginger extract, and the impact of this formulation on lipid metabolism and obesity was investigated using a rat model.

Methods

experiments, encompassing assessments of cell viability, microstructure, anti-inflammatory activity, and release dynamics, were conducted to comprehensively evaluate the nanoformulation. The study extended to examining the potential anti-obesity efficacy of the developed nanoformulation in rats induced with obesity through a high-fat diet.

Results

findings affirmed the safety of the carriers and revealed their robust anti-inflammatory properties. The average particle size for ginger-loaded and ginger-free chitosan nanoparticles was measured to be 458.92 ± 139.35 nm and 466.29 ± 142.71 nm, respectively. The investigation demonstrated the dose-dependent effects of ginger extract-loaded chitosan nanoparticles, manifesting in a reduction of obesity and improvement in liver function.

Conclusion

These promising results suggest that the developed nanoformulation could be considered a viable therapeutic option for individuals struggling with obesity.

© 2025 Bentham Science Publishers
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2024-07-18
2026-01-30

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Ginger Extract-Loaded Chitosan Nanoparticles: Investigating their Impact on Lipid Metabolism and Obesity in a Rat Model through In vitro and In vivo Analysis
Curr. Drug Deliv. 22, 1157 (2025); https://doi.org/10.2174/0115672018315676240715065750
/content/journals/cdd/10.2174/0115672018315676240715065750
/content/journals/cdd/10.2174/0115672018315676240715065750
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  • Article Type:     Research Article
Keyword(s): Chitosan nanoparticles; drug delivery, MTT assay, cell viability; ginger extract; obesity

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