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2000
Volume 22, Issue 5
  • ISSN: 1567-2018
  • E-ISSN: 1875-5704

Abstract

Introduction

Zeolitic imidazolate frameworks (ZIFs) play a crucial role among metal-organic frameworks due to their highly desirable properties, including high surface area, appropriate pore size, and excellent thermal and chemical stability.

Methods

In this study, ZIF-8 loaded with aspirin and coated using pectin (ZIF-8/Asp@Pectin) was utilized as a suitable and effective platform for the drug delivery system. The preparation of this coated MOF followed environmentally friendly methods, and aspirin was successfully loaded.

Results

Characterization of the obtained ZIF-8/Asp@Pectin was performed using X-ray diffraction (XRD), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), Fourier Transform Infrared (FT-IR) spectroscopy, and BET analysis.

Conclusion

The release of aspirin from ZIF-8/Asp@Pectin was studied using UV–Vis spectroscopy at 258 nm under conditions in HCl and PBS buffer solutions.

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2025-09-02

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/content/journals/cdd/10.2174/0115672018288328240109064308
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Controlled Release of Aspirin in the Body using Pectin-coated ZIF-8 Nanoparticles
Curr. Drug Deliv. 22, 583 (2025); https://doi.org/10.2174/0115672018288328240109064308
/content/journals/cdd/10.2174/0115672018288328240109064308
/content/journals/cdd/10.2174/0115672018288328240109064308
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  • Article Type:     Research Article
Keyword(s): aspirin; drug delivery system; MOF; pectin; ZIF-8; ZIF-8/Asp@Pectin

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