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image of Herbal Mucoadhesive Gels for Canker Sores: Analysis of Physicochemical Properties, Efficacy, and Safety

Abstract

Aim

The goal of this research was to formulate mucoadhesive gels using hydroglyceric extracts of L. and (L.) Aiton, either separately or in combination, utilizes carboxymethyl cellulose and detects their physicochemical characteristics and safety for oromucosal cells and antimicrobial (antibacterial, antifungal, and antiviral) efficacy to assess their performance.

Methods

Using LC-HRMS, the extracts of and were examined. Evaluations were conducted on the formulations' viscosity, cytotoxicity-cell proliferation controls, texture, antibacterial activity, pH, and organoleptic properties. The minimal inhibitory concentrations and microbroth dilution tests were used to assess the effectiveness of the formulations.

Results

The pH, organoleptic, and physical characteristics of each formulation have been determined to be appropriate. The research results demonstrated that contributed antiviral efficacy to the formulations linked to dose-dependent activities against all examined mouth pathogens, whereas provided antibacterial and antifungal efficacy. The formulation containing extract alone was the most cytotoxic, whereas the formulation including extract alone was the least cytotoxic against gingival fibroblast cells, according to the findings of tests on cell proliferation and cytotoxicity.

Conclusion

The formulation contained a 32% 1:1 mixture of and hydroglyceric extracts was detected as safe with acceptable cytotoxicity along with antibacterial and antiviral effectiveness, were encouraging for future investigations.

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2025-01-20
2026-01-01

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Herbal Mucoadhesive Gels for Canker Sores: Analysis of Physicochemical Properties, Efficacy, and Safety
Bentham Science Publishers ; https://doi.org/10.2174/0113862073341539241223195855
/content/journals/cchts/10.2174/0113862073341539241223195855
/content/journals/cchts/10.2174/0113862073341539241223195855
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  • Article Type:     Research Article
Keywords: efficacy-safety performance ; mucoadhesive gel ; canker sore ; hydroglyceric extracts ; Inula viscosa (L.) aiton ; rheology ; Cistus creticus L.

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