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2000
Volume 28, Issue 17
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

Aim

To study the mechanism by which curcumin regulates ovarian primordial follicle initiation in rats with triptolide-induced diminished ovarian reserve (DOR).

Methods

An gelatin sponge culture was performed on 3-day-old rat ovaries. After the establishment of the DOR model with triptolide, curcumin was administered for 3 days. Histological analysis and follicle counts were performed using H&E staining. ELISA detection of ovarian hormones in the culture medium (E, FSH and LH), western blotting and Q-PCR for protein and mRNA expression (LTCONS-00011173, TGF-β1, Smad1, AMH, PTEN and GDF-9).

Results

Ovarian primordial and growing follicles increased significantly after curcumin intervention ( < 0.05), FSH/LH and E levels were increased significantly ( < 0.05). Curcumin also significantly decreased the expression of LTCONS-00011173. Meanwhile, curcumin increased the expression of TGF-β, AMH, and GDF-9 ( < 0.05). In addition, curcumin increased Smad1 gene expression and protein phosphorylation in the ovary on the one hand ( < 0.05), but inhibited Smad1 and p-Smad1 protein expression on the other hand ( < 0.05). Moreover, curcumin decreased PTEN protein and mRNA expression ( < 0.05).

Conclusion

Curcumin activates primordial follicles in DOR model rats through TGF-β1 and downstream AMH signaling pathways and may limit follicle exhaustion through LncRNA.

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Regulation of Curcumin on Follicle Initiation Rate in Diminished Ovarian Reserve
Comb Chem High Throughput Screen 28, 3010 (2025); https://doi.org/10.2174/0113862073327087240926065629
/content/journals/cchts/10.2174/0113862073327087240926065629
/content/journals/cchts/10.2174/0113862073327087240926065629
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  • Article Type:     Research Article
Keyword(s): Curcumin; DOR; long non-coding RNA; primitive follicle initiation; Smad1; transforming growth factor-β

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