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2000
Volume 28, Issue 9
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

Background

Myocardial infarction (MI) is the foremost cause of mortality in cardiovascular diseases. MI ultimately exacerbates cardiotoxicity due to the release of toxicity biomarkers and inflammatory infiltration.

Aim

Vernodalin (VN) is a renowned cytotoxic sesquiterpene lactone that possesses antioxidant, anticancer, and anti-inflammatory properties. The cardioprotective mechanism of VN remains concealed. Hence, we explored the cardioprotective efficacy of VN on isoproterenol (ISO)-mediated MI and analyzed its underlying mechanism.

Methods

To investigate the cardioprotective potential of VN (10 mg/kg bw), Wistar albino rats were subcutaneously injected with ISO (85 mg/kg bw) to induce MI. The assessment included measurements of heart weight/body weight index, hemodynamics, toxicity enzymes, histology, inflammatory mediators, and signaling pathway. While decreasing hemodynamic parameters and VEGF-B, AMPK, and eNOS signaling pathways, ISO increased heart weight/body weight index, cardiotoxicity enzymes, biomarkers, inflammation, and histological alterations.

Results

Treatment with VN could significantly (p<0.05) mitigate the heart weight/body weight index, cardiotoxicity enzymes, biomarkers, inflammatory cytokines, and histopathological changes while enhancing hemodynamic parameters and VEGF-B, AMPK, and eNOS signaling pathways. Collectively, our findings revealed that the VN ameliorated defensive action against MI and averted myocardial injury by reducing the NF-κB-mediated inflammatory pathways in rats.

Conclusion

These findings established that VN expressively preserves the myocardium and employs anti-inflammatory actions by regulating NF-κB, VEGF-B, AMPK, and eNOS signaling pathways.

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2024-06-04
2025-11-04

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Vernodalin Alleviates Cardiotoxicity and Inflammation in Isoproterenol-Mediated Myocardial Infarction through NF-κB/AMPK Signaling Pathways in Rats
Comb Chem High Throughput Screen 28, 1594 (2025); https://doi.org/10.2174/0113862073302291240528055742
/content/journals/cchts/10.2174/0113862073302291240528055742
/content/journals/cchts/10.2174/0113862073302291240528055742
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  • Article Type:     Research Article
Keyword(s): cardiovascular diseases (CVD); inflammation; isoproterenol; myocardial infarction; VEGF-B/AMPK/eNOS signaling; Vernodalin

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