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2000
Volume 28, Issue 2
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402
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Abstract

Background

Jinwei decoction can enhance the anti-inflammatory effect of glucocorticoid (GC) on chronic obstructive pulmonary disease (COPD) by restoring the activity of human histone deacetylase-2 (HDAC2). However the upstream mechanism of Jinwei decoction on HDAC2 expression is not clear.

Objective

To explore the target of Jinwei decoction to enhance the anti-inflammatory effect of GC on COPD through microRNA155-5p (miR-155-5p) by network pharmacology and experimental verification.

Methods

The TCMSP database was used to screen active ingredients and target genes of Jinwei decoction, and miRWalk2.0 was used to predict downstream target genes of miR-155-5p. COPD-related genes were identified by searching GeneCards, Grugbank and OMIM databases; Venny 2.1 was used to screen intersection genes; Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of intersection genes were analyzed by R software. Protein-protein interactions (PPIs) were analyzed by Cytoscape 3.7.2 software to identify core genes. Finally, interactions between main compounds and potential targets were verified by molecular docking. A COPD cell model was established by 5% cigarette smoke extract (CSE)-induced bronchial epithelial cell (BEAS-2B), and the results of network pharmacology were verified by experiments.

Results

Two hundred thirty-one active ingredients, 352 Jinwei decoction drug targets, 5949 miR-155-5p target genes, 8286 COPD target genes, and 127 intersection genes were identified. Twelve core proteins of PPI networks may be involved. GO enrichment analysis showed that regulation of membrane potential, response to steroid hormone, and histone modification were involved; KEGG pathway enrichment analysis concentrated in the PI3K-Akt, mitogen-activated protein kinase (MAPK), HIF-1, and other signaling pathways. The molecular docking results showed that quercetin, luteolin and stigmasterol have higher affinity with PTGS2, HIF1A and AKT1. The results of cell experiments revealed that Jinwei decoction not only enhances the anti-inflammatory effect of GC in the COPD cell model but also reverses the high expression of miR-155-5p、PI3k、Akt, and low expression of HDAC2, thereby inhibiting the inflammatory response of COPD.

Conclusion

Jinwei decoction can regulate HDAC2 activity and enhance the anti-inflammatory effect of GC on COPD by modulating miR-155-5p. Its mechanism of action may be related to its effect on the PI3K-Akt through miR-155-5p.

© 2025 Bentham Science Publishers
© 2025 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/cchts/10.2174/0113862073279344240215050056
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Network Pharmacology and Experimental Validation of Jinwei Decoction for Enhancement of Glucocorticoid Anti-Inflammatory Effect in COPD through miR-155-5p
Comb Chem High Throughput Screen 28, 351 (2025); https://doi.org/10.2174/0113862073279344240215050056
/content/journals/cchts/10.2174/0113862073279344240215050056
/content/journals/cchts/10.2174/0113862073279344240215050056
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All Information on TCM ingredients of Jinwei decoction (Table ). Target Genes of TCM ingredients of Jinwei decoction (Table ). Target Genes of miR-155-5p (Table ). Target Genes of COPD in GeneCards Databases (Table ). Target Genes of COPD in OMIM Databases (Table ). Target Genes of COPD in Drugbank Databases (Table ). Mass spectrometry analysis of Jinwei Tang (Word ).

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  • Article Type:     Research Article
Keyword(s): anti-inflammatory; chronic obstructive pulmonary disease; hormone resistance; Jinwei decoction; miR-155-5p; Network pharmacology

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