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2000
Volume 25, Issue 12
  • ISSN: 1568-0096
  • E-ISSN: 1873-5576

Abstract

Background

Cytochrome P450 (CYP) enzymes are involved in the metabolism of xenobiotic and carcinogen. In the study, we evaluated the association of and variants with lung cancer.

Methods

Five polymorphisms in and four polymorphisms in were genotyped in 507 lung cancer patients and 505 controls with Agena MassARRAY platform. The linkage of variants with lung cancer risk was evaluated by odds ratio (OR) and 95% confidence interval (CI) in genetic models and haplotype analyses.

Results

We found that rs1934967 alleles were associated with lung cancer risk ( < 0.05). In stratified analysis, rs2280274 (women, non-smoker, non-drinker and lymphatic metastasis), rs11207535 (non-smoker and non-drinker), rs10889159 (non-smoker and non-drinker) of , whereas rs1934967 (age ≤ 60, BMI > 24, squamous carcinoma) of decreased lung cancer risk ( < 0.05). In addition, the results of linkage disequilibrium (LD) analysis showed that rs2280274|rs4388726 - TG (with adjustment: = 0.042) of and rs10509679|rs1934967| rs1934968|rs9332220 – GTGG (without adjustment: = 0.044) of were linked with a significantly decreased lung cancer risk.

Conclusion

Our results indicated genetic variants in and might contribute to the susceptibility of lung cancer in Chinese population.

© 2025 Bentham Science Publishers
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References

  1. OzbayerC. DegirmenciI. UstunerD. AkG. SaydamF. ColakE. GunesH.V. MetintasM. miRSNPs of miR1274 and miR3202 genes that target MeCP2 and DNMT3b are associated with lung cancer risk: A study conducted on MassARRAY genotyping.J. Environ. Pathol. Toxicol. Oncol.2016353223236
     [Google Scholar]
  2. TangM. XuW. WangQ. XiaoW. XuR. Potential of DNMT and its epigenetic regulation for lung cancer therapy.Curr. Genomics200910533635210.2174/138920209788920994 20119531
     [Google Scholar]
  3. SungH. FerlayJ. SiegelR.L. LaversanneM. SoerjomataramI. JemalA. BrayF. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.CA Cancer J. Clin.202171320924910.3322/caac.21660 33538338
     [Google Scholar]
  4. SiegelR.L. MillerK.D. FuchsH.E. JemalA. Cancer Statistics, 2021.CA Cancer J. Clin.202171173310.3322/caac.21654 33433946
     [Google Scholar]
  5. CaoW. ChenH.D. YuY.W. LiN. ChenW.Q. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020.Chin. Med. J. (Engl.)2021134778379110.1097/CM9.0000000000001474 33734139
     [Google Scholar]
  6. MaoY. YangD. HeJ. KrasnaM.J. Epidemiology of lung cancer.Surg. Oncol. Clin. N. Am.201625343944510.1016/j.soc.2016.02.001 27261907
     [Google Scholar]
  7. SunJ.Z. YangX.-x. HuN.-y. LiX. LiF.-x. LiM. Genetic variants inMMP9andTCF2contribute to susceptibility to lung cancer.Chin J Cancer Res.2011233183187
     [Google Scholar]
  8. GrimmingerP.P. StöhlmacherJ. VallböhmerD. SchneiderP.M. HölscherA.H. MetzgerR. DanenbergP.V. BrabenderJ. Prognostic significance and clinicopathological associations of COX-2 SNP in patients with nonsmall cell lung cancer.J. Oncol.2009200913959010.1155/2009/139590
     [Google Scholar]
  9. CrosbieP.A. McgownG. ThorncroftM.R. O'DonnellP.N. BarberP.V. LewisS.J. HarrisonK.L. AgiusR.M. SantibanezkorefM.F. MargisonG.P. Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6-alkylguanine-DNA alkyltransferase.Int J Cancer.20101224791795
     [Google Scholar]
  10. YinZ. SuM. LiX. ERCC2,ERCC1polymorphisms and haplotypes, cooking oil fume and lung adenocarcinoma risk in Chinese non-smoking females.J. Exp. Clin. Cancer Res.2009281153
     [Google Scholar]
  11. KiyoharaC. HoriuchiT. TakayamaK. NakanishiY. IL1B rs1143634 polymorphism, cigarette smoking, alcohol use, and lung cancer risk in a Japanese Population.J. Thorac. Oncol.201053299304
     [Google Scholar]
  12. ChenC. WangD.W. Cytochrome P450-CYP2 Family-Epoxygenase Role in Inflammation and Cancer.Adv. Pharmacol.20157419322110.1016/bs.apha.2015.04.005 26233908
     [Google Scholar]
  13. ChenC. WangD. CYP epoxygenase derived EETs: From cardiovascular protection to human cancer therapy.Curr. Top. Med. Chem.201313121454146910.2174/1568026611313120007 23688135
     [Google Scholar]
  14. ChenG. XuR. WangY. WangP. ZhaoG. XuX. GruzdevA. ZeldinD.C. WangD.W. Genetic disruption of soluble epoxide hydrolase is protective against streptozotocin-induced diabetic nephropathy.Am. J. Physiol. Endocrinol. Metab.20123035E563E57510.1152/ajpendo.00591.201122739108
     [Google Scholar]
  15. ZhaoG. TuL. LiX. YangS. ChenC. XuX. WangP. WangD.W. Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6-nephrectomized rat via inhibition of apoptosis and fibrosis.Hum. Gene Ther.201223768869910.1089/hum.2011.135 22260463
     [Google Scholar]
  16. ChenG. XuR. ZhangS. WangY. WangP. EdinM.L. ZeldinD.C. WangD.W. CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice.Am. J. Physiol. Endocrinol. Metab.20153082E97E11010.1152/ajpendo.00366.2014 25389366
     [Google Scholar]
  17. LiR. XuX. ChenC. WangY. GruzdevA. ZeldinD.C. WangD.W. CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPARγ.Am. J. Physiol. Endocrinol. Metab.20153084E270E282
     [Google Scholar]
  18. MaB. XiongX. ChenC. LiH. XuX. LiX. LiR. ChenG. DackorR.T. ZeldinD.C. WangD.W. Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice.Endocrinology201315482843285610.1210/en.2012‑2166 23696562
     [Google Scholar]
  19. PanigrahyD. GreeneE.R. PozziA. WangD.W. ZeldinD.C. EET signaling in cancer.Cancer Metastasis Rev.2011303-4525540
     [Google Scholar]
  20. WangX. XuY. XuK. ChenY. XiaoX. GuanX. BCL11A confers cell invasion and migration in androgen receptor positive triple negative breast cancer.Oncol. Lett.20201942916292410.3892/ol.2020.11383 32218847
     [Google Scholar]
  21. LeeG.Y. KimN.H. ZhaoZ.S. ChaB.S. KimY.S. Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level.Biochem J.2004378Pt 398399010.1042/bj20031565
     [Google Scholar]
  22. PozziA. PopescuV. YangS. MeiS. ShiM. PuolitaivalS.M. CaprioliR.M. CapdevilaJ.H. The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated.J. Biol. Chem.201028517128401285010.1074/jbc.M109.081554 20178979
     [Google Scholar]
  23. LeeC.R. GoldsteinJ.A. PieperJ.A. Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.Pharmacogenetics200212325126310.1097/00008571‑200204000‑00010 11927841
     [Google Scholar]
  24. FuZ. ZhuQ. MaY. HuangD. PanS. XieX. LiuF. ChaE. Diplotypes of CYP2C9 gene is associated with coronary artery disease in the Xinjiang Han population for women in China.Lipids Health Dis.201413114310.1186/1476‑511X‑13‑143 25182955
     [Google Scholar]
  25. LiaoL.H. ZhangH. LaiM.-P. LauK.-W. LaiA.K.-C. ZhangJ.-H. WangQ. WeiW. ChaiJ.-H. LungM.L. The association of CYP2C9 gene polymorphisms with colorectal carcinoma in Han Chinese.Clin. Chim. Acta20073801-2191196
     [Google Scholar]
  26. LondonS.J. DalyA.K. LeathartJ.B.S. NavidiW.C. IdleJ.R. Lung cancer risk in relation to the CYP2C9*1/CYP2C9*2 genetic polymorphism among African-Americans and Caucasians in Los Angeles County, California.Pharmacogenetics19966652753310.1097/00008571‑199612000‑00006 9014202
     [Google Scholar]
  27. ZhouJ. YangY. ZhangD. ZhouL. TaoL. LuL.M. Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma.PLoS One2017122e017111610.1371/journal.pone.0171116 28225775
     [Google Scholar]
  28. DempkeW. Von PoblozkiA. GrotheyA. SchmollH.J. Human hematopoietic growth factors: Old lessons and new perspectives.Anticancer Res.2000206D51555164 11326688
     [Google Scholar]
  29. JinX. ZhangK.J. GuoX. MyersR. YeZ. ZhangZ.P. LiX.F. YangH.S. XingJ.L. Fatty acid synthesis pathway genetic variants and clinical outcome of non-small cell lung cancer patients after surgery.Asian Pac J Cancer Prev.201415177097710310.7314/APJCP.2014.15.17.7097
     [Google Scholar]
  30. PereiraE.E.B. LeitãoL.P.C. AndradeR.B. ModestoA.A.C. FernandesB.M. BurbanoR.M.R. AssumpçãoP.P. FernandesM.R. GuerreiroJ.F. SantosS.E.B. SantosN.P.C. UGT1A1 Gene polymorphism contributes as a risk factor for lung cancer: A pilot study with patients from the Amazon.Genes (Basel)202213349310.3390/genes13030493 35328047
     [Google Scholar]
  31. LanX. LiY. WuY. LiX. XuL. The Association of ERCC1 and ERCC5 polymorphisms with lung cancer risk in han.Chinese J. Cancer202213251752610.7150/jca.59277 35069899
     [Google Scholar]
  32. YuY. MaoL. ChengZ. ZhuX. CuiJ. FuX. ChengJ. ZhouY. QiuA. DongY. ZhuangX. LuY. LianY. TianT. WuS. ChuM. A novel regQTL-SNP and the risk of lung cancer: a multi-dimensional study.Arch. Toxicol.202195123815382710.1007/s00204‑021‑03170‑5 34596730
     [Google Scholar]
  33. CapdevilaJ.H. FalckJ.R. HarrisR.C. Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase.J. Lipid Res.200041216318110.1016/S0022‑2275(20)32049‑6 10681399
     [Google Scholar]
  34. ZeldinD.C. PlitmanJ.D. KobayashiJ. MillerR.F. SnapperJ.R. FalckJ.R. SzarekJ.L. PhilpotR.M. CapdevilaJ.H. The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance.J. Clin. Invest.19959552150216010.1172/JCI117904 7738183
     [Google Scholar]
  35. TaoH. MaX. SuG. YinJ. XieX. HuC. ChenZ. TanD. XuZ. ZhengY. LiuH. HeC. MaoZ.J. YinH. WangZ. ChangW. GaleR.P. ChenZ. WuD. YinB. BCL11A expression in acute myeloid leukemia.Leuk. Res.201641717510.1016/j.leukres.2015.12.001 26707798
     [Google Scholar]
  36. GarcíAmartí, N.; MartíNez, E.C.; Ladero, J.M.; Gamito, F.J.G.; Rodriguezlescure, A.; Agúndez, J.A.G. Influence of cytochrome P450 CYP2C9 genotypes in lung cancer risk.Cancer Lett.200218014146
     [Google Scholar]
  37. MinnA.-L. Characterization of microsomal cytochrome p450-dependent monooxygenases in the rat olfactory mucosa.Drug Metabol. Disposit.20053381229123710.1124/dmd.105.004085
     [Google Scholar]
  38. LondonS. SmartJ. Lung cancer risk in relation to genetic polymorphisms of microsomal epoxide hydrolase among African-Americans and Caucasians in Los Angeles County.Lung Cancer.,2000282147155
     [Google Scholar]
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Variants in CYP2J2 and CYP2C9 Contribute to Susceptibility of Lung Cancer
Curr. Cancer Drug Targets< 25, 1568 (2025); https://doi.org/10.2174/1568009623666221114115012
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  • Article Type:     Research Article
Keyword(s): carcinogen; CYP2C9; CYP2J2; genetic polymorphisms; Lung cancer; susceptibility

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