The Roles of Alternative Splicing in Tumor-immune Cell Interactions

Yue Wang; Honglei Zhang; Baowei Jiao; Jianyun Nie; Xiyin Li; Wenhuan Wang; Hairui Wang

doi:10.2174/1568009620666200619123725

ISSN: 1568-0096
E-ISSN: 1873-5576

s The Roles of Alternative Splicing in Tumor-immune Cell Interactions
By Yue Wang, Honglei Zhang, Baowei Jiao, Jianyun Nie, Xiyin Li, Wenhuan Wang and Hairui Wang
Source: Current Cancer Drug Targets, Volume 20, Issue 10, Nov 2020, p. 729 - 740
DOI: https://doi.org/10.2174/1568009620666200619123725
- Available online: 01 Nov 2020

Abstract

Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated tumor specific-antigens (TSAs) produced by AS. We further discuss the regulating mechanisms involved in AS-mediated innate and adaptive immune responses and the anti-tumoral and protumoral roles in different types of cancer. For example, ULBP1_RI, MLL5Δ21spe, NKp44-1Δ5, MHC-IΔ7, CD200SΔ1, 2, PVR α/β/γ/δ and IL-33 variants 1/2/3 act as regulators in solid tumors and IPAK4-L and, FOXP1ΔN100 exhibit functions in hematological cancers.

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2020-11-01

2025-09-06

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Article Type: Review Article

Keyword(s): Alternative splicing; immune system; immunotherapy; neoantigens; tumor cells; Tumor specific-antigens (TSAs)

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s The Roles of Alternative Splicing in Tumor-immune Cell Interactions

Abstract

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