Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer

Junsong Chen; Na Niu; Jing Zhang; Lisha Qi; Weiwei Shen; Krishna V. Donkena; Zhenqing Feng; Jinsong Liu

doi:10.2174/1568009618666180703154233

ISSN: 1568-0096
E-ISSN: 1873-5576

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer
By Junsong Chen, Na Niu, Jing Zhang, Lisha Qi, Weiwei Shen, Krishna V. Donkena, Zhenqing Feng and Jinsong Liu
Source: Current Cancer Drug Targets, Volume 19, Issue 5, May 2019, p. 360 - 367
DOI: https://doi.org/10.2174/1568009618666180703154233
- Available online: 01 May 2019

Abstract

Polyploidy is associated with increased cell size and is commonly found in a subset of adult organs and blastomere stage of the human embryo. The polyploidy is formed through endoreplication or cell fusion to support the specific need of development including earliest embryogenesis. Recent data demonstrated that Polyploid Giant Cancer Cells (PGCCs) may have acquired an activated early embryonic-like program in response to oncogenic and therapeutic stress to generate reprogrammed cancer cells for drug resistance and metastasis. Targeting PGCCs may open up new opportunities for cancer therapy.

Article metrics loading...

/content/journals/ccdt/10.2174/1568009618666180703154233

2019-05-01

2025-10-27

From This Site

/content/journals/ccdt/10.2174/1568009618666180703154233

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/ccdt/10.2174/1568009618666180703154233

Article Type: Review Article

Keyword(s): blastomere-like cancer stem cells; cancer stem cells; cell fusion; endoreplication; Polyploid giant cancer cells; reprogramming

Most Cited Most Cited RSS feed

- Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy
  
  Authors: Yong Lin, Ranxin Shi, Xia Wang and Han-Ming Shen
- The Role of Snail in EMT and Tumorigenesis
  
  Authors: Yifan Wang, Jian Shi, Kequn Chai, Xuhua Ying and Binhua P. Zhou
- The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications
  
  Authors: Amancio Carnero, Carmen Blanco-Aparicio, Oliver Renner, Wolfgang Link and Juan F.M. Leal
- Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives
  
  Authors: D. Chen, M. Frezza, S. Schmitt, J. Kanwar and Q. P. Dou
- P-glycoprotein Inhibition as a Therapeutic Approach for Overcoming Multidrug Resistance in Cancer: Current Status and Future Perspectives
  
  Authors: Ziyad Binkhathlan and Afsaneh Lavasanifar
- Taxanes: Microtubule and Centrosome Targets, and Cell Cycle Dependent Mechanisms of Action
  
  Authors: M. Abal, J.M. Andreu and I. Barasoain
- Paclitaxel Resistance: Molecular Mechanisms and Pharmacologic Manipulation
  
  Authors: R.Z. Yusuf, Z. Duan, D.E. Lamendola, R.T. Penson and M.V. Seiden
- The Role of Fibroblast Growth Factors in Tumor Growth
  
  Authors: M. Korc and R. E. Friesel
- Garlic [Allium sativum]: A Review of its Potential Use as an Anti-Cancer Agent
  
  Authors: M. Thomson and M. Ali
- Oxidative Stress and Cancer: The Role of Nrf2
  
  Authors: Soraya Sajadimajd and Mozafar Khazaei
More Less

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer

Abstract

Most Read This Month

Most Cited Most Cited RSS feed