NEDD4: A Promising Target for Cancer Therapy

Xiantao Ye; Lixia Wang; Bingxue Shang; Zhiwei Wang; Wenyi Wei

doi:10.2174/1568009614666140725092430

ISSN: 1568-0096
E-ISSN: 1873-5576

NEDD4: A Promising Target for Cancer Therapy
By Xiantao Ye, Lixia Wang, Bingxue Shang, Zhiwei Wang and Wenyi Wei
Source: Current Cancer Drug Targets, Volume 14, Issue 6, Jul 2014, p. 549 - 556
DOI: https://doi.org/10.2174/1568009614666140725092430
- Available online: 01 Jul 2014

Abstract

The Neuronally expressed developmentally downregulated 4 (NEDD4), functioning largely as an E3 ubiquitin ligase, has been demonstrated to play a critical role in the development and progression of human cancers. In this review, to understand the regulatory mechanism(s) of NEDD4 as well as the signaling pathways controlled by NEDD4, we briefly describe the NEDD4 upstream regulators and its downstream ubiquitin substrates. Moreover, we further discuss its oncogenic roles in human malignancies. Therefore, targeting NEDD4 could be a potential therapeutic strategy for treatment of human cancers.

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2014-07-01

2025-11-03

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Article Type: Research Article

Keyword(s): Cancer; E3 ligase; NEDD4; oncogene; target; therapy; ubiquitination

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NEDD4: A Promising Target for Cancer Therapy

Abstract

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