Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?

Philippe Marchetti; Pierre Guerreschi; Jerome Kluza; Laurent Mortier

doi:10.2174/1568009614666140407113124

ISSN: 1568-0096
E-ISSN: 1873-5576

Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?
By Philippe Marchetti, Pierre Guerreschi, Jerome Kluza and Laurent Mortier
Source: Current Cancer Drug Targets, Volume 14, Issue 4, May 2014, p. 357 - 370
DOI: https://doi.org/10.2174/1568009614666140407113124
- Available online: 01 May 2014

Abstract

In recent years, our knowledge regarding the metabolism of melanoma has greatly advanced and consequently new therapeutic strategies are being developed. This review is focused on metabolic pathways contributing to melanoma proliferation, the influence of BRAF inhibitors on those metabolic pathways and finally a presentation of potential therapeutic strategies aimed at blocking metabolic signaling pathways and therefore melanoma development.

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2014-05-01

2025-11-01

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Article Type: Research Article

Keyword(s): Glycolysis; mitochondria; oxidative stress; warburg

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Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?

Abstract

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