CXCL3 is a Potential Target for Breast Cancer Metastasis

Amanda Lay Pin See; Poh Kuan Chong; Ssu-Yi Lu; Yoon Pin Lim

doi:10.2174/1568009614666140305222328

ISSN: 1568-0096
E-ISSN: 1873-5576

CXCL3 is a Potential Target for Breast Cancer Metastasis
By Amanda Lay Pin See, Poh Kuan Chong, Ssu-Yi Lu and Yoon Pin Lim
Source: Current Cancer Drug Targets, Volume 14, Issue 3, Mar 2014, p. 294 - 309
DOI: https://doi.org/10.2174/1568009614666140305222328
- Available online: 01 Mar 2014

Abstract

Secreted proteins are an attractive minefield for cancer drug targets. An iTRAQ-based tandem mass spectrometry approach was employed to relatively quantify proteins in the secretomes of four isogenic breast cancer cell lines with increasing metastatic potential. CXCL3 was found to be upregulated in aggressive cancer cells. SiRNA and antibody neutralization studies supported a role of CXCL3 in metastatic processes. Meta-analysis of the mRNA level of CXCL3 in 1881 breast tumors supported a role of CXCL3 in clinical breast cancer. Our results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy.

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2014-03-01

2025-12-17

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Article Type: Research Article

Keyword(s): Breast cancer; chemokine; CXCL3; migration; proteomics; secretome

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CXCL3 is a Potential Target for Breast Cancer Metastasis

Abstract

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