Role of TGF- β in the Tumor Stroma

H. P.H. Naber; P. ten Dijke; E. Pardali

doi:10.2174/156800908785699342

ISSN: 1568-0096
E-ISSN: 1873-5576

Role of TGF- β in the Tumor Stroma
By H. P.H. Naber, P. ten Dijke and E. Pardali
Source: Current Cancer Drug Targets, Volume 8, Issue 6, Sep 2008, p. 466 - 472
DOI: https://doi.org/10.2174/156800908785699342
- Available online: 01 Sep 2008

Abstract

Recent findings have demonstrated that the tumor stroma actively contributes to tumorigenesis. The communication of malignant cells and tumor stromal components is orchestrated in part by a network of growth factors. One of these growth factors is transforming growth factor-β (TGF-β), a secreted multifunctional protein that acts in a highly cellular contextual manner. TGF-β can either stimulate or inhibit the tumor-promoting effects of the different components of the tumor stroma. In this review, we discuss our current understanding on how TGF-β influences different stromal compartments.

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2008-09-01

2025-12-10

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Article Type: Research Article

Keyword(s): angiogenesis; CAF; immune cells; TGF-β; tumor stroma

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Role of TGF- β in the Tumor Stroma

Abstract

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