Disruption of Metabolic Pathways - Perspectives for the Treatment of Cancer

Eliana P. Araujo; Jose B. Carvalheira; Licio A. Velloso

doi:10.2174/156800906775471734

ISSN: 1568-0096
E-ISSN: 1873-5576

Disruption of Metabolic Pathways - Perspectives for the Treatment of Cancer
Authors: Eliana P. Araujo¹, Jose B. Carvalheira² and Licio A. Velloso³
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¹ DCM - FCM, UNICAMP, 13084-970, Campinas SP, Brazil. ² DCM - FCM, UNICAMP, 13084-970, Campinas SP, Brazil. ³ DCM - FCM, UNICAMP, 13084-970, Campinas SP, Brazil.
Source: Current Cancer Drug Targets, Volume 6, Issue 1, Feb 2006, p. 77 - 87
DOI: https://doi.org/10.2174/156800906775471734
- Available online: 01 Feb 2006

Abstract

Several growth-promoting signaling pathways have tight molecular connections with metabolicrelated signal transduction systems. By controlling these pathways, cancer cells gain autonomy over energyacquiring systems and, thus, expand their potential for proliferation. Here, we discuss the use of drug and antisense oligonucleotide approaches to inhibit metabolic pathways in cancer cells and their potential use in the therapeutics of cancer.

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2006-02-01

2025-10-12

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Article Type: Research Article

Keyword(s): Akt Activation; Antisense oligonucleotides; CCI-779; phosphotyrosine binding (PTB); protein kinase B; protein remodeling

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Disruption of Metabolic Pathways - Perspectives for the Treatment of Cancer

Abstract

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