Squalamine: A Polyvalent Drug of the Future?

Jean M. Brunel; Chanaz Salmi; Celine Loncle; Nicolas Vidal; Yves Letourneux

doi:10.2174/1568009054064642

ISSN: 1568-0096
E-ISSN: 1873-5576

Squalamine: A Polyvalent Drug of the Future?
Authors: Jean M. Brunel¹, Chanaz Salmi², Celine Loncle³, Nicolas Vidal⁴ and Yves Letourneux⁵
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¹ IMRN UMR INRA 1111, Case 342, Laboratoire SESNAB Faculte de St Jerome, Universite Paul Cezanne, Av. Escadrille Normandie Niemen, 13397 Marseille, Cedex 20, France. ² IMRN UMR INRA 1111, Case 342, Laboratoire SESNAB Faculte de St Jerome, Universite Paul Cezanne, Av. Escadrille Normandie Niemen, 13397 Marseille, Cedex 20, France. ³ IMRN UMR INRA 1111, Case 342, Laboratoire SESNAB Faculte de St Jerome, Universite Paul Cezanne, Av. Escadrille Normandie Niemen, 13397 Marseille, Cedex 20, France. ⁴ IMRN UMR INRA 1111, Case 342, Laboratoire SESNAB Faculte de St Jerome, Universite Paul Cezanne, Av. Escadrille Normandie Niemen, 13397 Marseille, Cedex 20, France. ⁵ IMRN UMR INRA 1111, Case 342, Laboratoire SESNAB Faculte de St Jerome, Universite Paul Cezanne, Av. Escadrille Normandie Niemen, 13397 Marseille, Cedex 20, France.
Source: Current Cancer Drug Targets, Volume 5, Issue 4, Jun 2005, p. 267 - 272
DOI: https://doi.org/10.2174/1568009054064642
- Available online: 01 Jun 2005

Abstract

The purpose of this mini-review is to summarize and highlight the different advances in our understanding of the antimicrobial and antiangiogenic activity of squalamine, a cationic steroid isolated in 1993 from the dogfish shark Squalus Acanthias. Indeed, squalamine has shown to be useful for the treatment of important diseases such as cancers (lung, ovarian, brain and others), age-related macular degeneration (AMD) and the control of body weight in man. All these results led to a question: could we consider squalamine as a polyvalent drug of the future?

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2005-06-01

2025-09-05

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Article Type: Review Article

Keyword(s): age-related macular degeneration (amd); aminosterol; appetite suppression; cancer; squalamine; weight reduction

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Squalamine: A Polyvalent Drug of the Future?

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