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image of Migrasomes: A Novel Target for Cancer Treatment

Abstract

Protrusion and adhesion occur at the foremost point of cells during cell migration, while contraction and detachment occur at the rear of the cells. The combined action of cytoskeletal dynamics, vesicular trafficking, and signaling networks initiates this multi-step process. The development of a novel exosome-like organelle called migrasomes, which may play roles in intercellular signaling, and which originate from retraction fibers at the back of migrating cells. Migrasomes are a particular kind of extracellular vesicle that is placed by a special mechanism and left behind by migrating cells. The proteins called integrins, which connect cells to the extracellular matrix (ECM), regulate the mobilization of migrasome. The function of migrasomes is to preserve cellular homeostasis and communication between cells. By observing this literature, we attempted to ascertain the potential role that migrasomes will play in the future in illnesses involving migrating cells, like immune system problems, tumor metastasis, and other disorders.

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2025-07-22
2025-08-05

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Migrasomes: A Novel Target for Cancer Treatment
Bentham Science Publishers ; https://doi.org/10.2174/0115680096359140250324085405
/content/journals/ccdt/10.2174/0115680096359140250324085405
/content/journals/ccdt/10.2174/0115680096359140250324085405
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  • Article Type:     Research Article
Keywords: retraction fibers ; immune systems ; tumors ; detachment ; Contraction ; migrasomes

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