Current Chemical Biology - Volume 18, Issue 4, 2024

BackgroundFusarium oxysporum f. sp. Albedinis a telluric fungal pathogen commonly found in soils, is the causal agent of fungal vascular wilt of date palms in Moroccan oases. The infection by the pathogen leads to the death of the date palm after six months to two years, which causes enormous economic and environmental damage.ObjectiveThe framework of this paper is to determine the chemical composition of six Read More

Introduction/ObjectiveThe use of lacatomtom (LTT), a psychoactive mixture of tomtom (TT) candies with lacasera (LC) beverage, has recently increased among young Nigerians and Africans. There isn't much scientific study on the constituent and effects of this psychoactive substance.MethodsHerein, LTT was chemically-profiled using GCMS analysis, and the toxicological effects were examined in albino rats. I Read More

Background The most common Inflammatory Bowel Diseases (IBD) affecting the gastrointestinal system are Crohn's disease and ulcerative colitis. However, the usual therapies for them are associated with a multitude of side effects. The blue-green microalgae Arthrospira platensis is known for its safety profile, nutritional, and medicinal properties in the treatment of different inflammatory and gastrointestinal disorders. Objectiv Read More

BackgroundNumerous natural products have been successfully developed for clinical use in the treatment of human diseases in almost every therapeutic area.ObjectiveThis work aimed to synthesize some new analogs of carlina oxide by functionalizing the fifth position of the furan by different acyl groups using the Friedel-Crafts acylation approach. The synthetic analogs and carlina oxide were then assessed for their in Read More

IntroductionGallic acid (GA), a natural phenolic acid, has been reported as an antitumor agent in various cancer cells. Although some mechanisms, such as apoptosis, are well known, the details of other mechanisms, such as their pro-oxidant and autophagy activity, are still considerable.MethodsThe pro-oxidative activity and anti-proliferative activity of GA on HEK 293 and HepG2 cells were measured in the a Read More